About the MRL

The Mycobacteria Research Laboratories was founded some 25 years ago by Dr. Patrick J. Brennan and colleagues with the intent of generating an internationally recognized center of excellence for the study of mycobacterial diseases and pathogens. Since then, the MRL has been at the forefront of mycobacterial fundamental and translational research. Research programs in the MRL utilize state-of-the-art techniques and facilities to address

  • tuberculosis vaccine and drug development,
  • leprosy and tuberculosis diagnostics,
  • the study of nontuberculous mycobacterial diseases and Buruli ulcer,
  • and the epidemiology and diagnostics of mycobacterial diseases affecting animals including bovine tuberculosis and Johne’s disease.

More about the MRL

News & Events

Tuberculosis Innovation at CSU

Meet the TB Research Team Members

Press Releases


Stop TB in my lifetimeOn March 24th, dozens of northern Colorado high-school students will gain an inside look at an infectious disease that kills an estimated 1.5 million people each year – and the urgent scientific quest to halt it.

The lab-level view of tuberculosis comes courtesy of the world’s largest group of university researchers investigating TB: a Colorado State University brain trust of about 170 experts in all aspects of the disease. To learn more, read the article “Tuberculosis: Global killer with Colorado connection”


MRL Researcher, Dr. Ian Orme, is collaborating with the biopharmaceutical company GlobelImmune to create a new type of immunotherapeutic vaccine designed to prevent and treat tuberculosis.  To learn more, read the article “CSU researcher and biopharmaceutical company seek tuberculosis treatment”

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Leprosy Research in Brazil

Zoonotic TB Research

Colorado State University

Dr. Francisco Olea-Popelka, a veterinary epidemiologist with the MRL, is the chairman of The Union’s Zoonotic TB Sub-Section. The sub-section monitors the transmission of tuberculosis between animals and people, especially in underserved communities in developing countries. To learn more, read the article in the Union E-News.

Outstanding Work

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Crystal Shanley, a Research Associate in Dr. Ian Orme’s lab, has been recognized for her outstanding achievement in the care of research and teaching animals. Crystal was awarded the Technician of the Year for 2014. Crystal was instrumental in training an international Gates Foundation TB staff team in Witbank on the needed techniques for guinea pig vaccinations. Her stress-free procedure has been adopted by other laboratories in the TB field.

© 2012 Colorado State University, Fort Collins, Colorado 80523 USA  |  T.O.P.S.