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Bartek IL, Reichlen MJ, Honaker RW, Leistikow RL, Clambey ET, Scobey MS, Hinds AB, Born SE, Covey CR, Schurr MJ, Lenaerts AJ, Voskuil MI. Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis. mSphere. 2016 Aug 24;1(4). pii: e00176-16. doi: 10.1128/mSphere.00176-16. PubMed PMID: 27579369; PubMed Central PMCID: PMC4999920.

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Beltrán-Alzate C, López Díaz F, Romero-Montoya M, Sakamuri R, Li W, Kimura M, Brennan P, Cardona-Castro N. Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country. PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005041. doi: 10.1371/journal.pntd.0005041. PubMed PMID: 27706165; PubMed Central PMCID: PMC5051701.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ. Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity. J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. PubMed PMID: 27187871; PubMed Central PMCID: PMC4917603.

Brennan PJ. Bacterial evolution: Emergence of virulence in TB. Nat Microbiol. 2016 Jan 27;1:15031. doi: 10.1038/nmicrobiol.2015.31. PubMed PMID: 27571983.

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Crawford AC, Laurentius LB, Mulvihill TS, Granger JH, Spencer JS, Chatterjee D, Hanson KE, Porter MD. Detection of the tuberculosis antigenic marker mannose-capped lipoarabinomannan in pretreated serum by surface-enhanced Raman scattering. Analyst. 2016 Dec 19;142(1):186-196. PubMed PMID: 27924983.

Datta G, Nieto LM, Davidson RM, Mehaffy C, Pederson C, Dobos KM, Strong M. Longitudinal whole genome analysis of pre and post drug treatment Mycobacterium tuberculosis isolates reveals progressive steps to drug resistance. Tuberculosis (Edinb). 2016 May;98:50-5. doi: 10.1016/j.tube.2016.02.004. PubMed PMID: 27156618.

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R. Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection. J Clin Microbiol. 2017 Feb;55(2):391-402. doi: 10.1128/JCM.01646-16. PubMed PMID: 27852671.

Diaz G, Wolfe LM, Kruh-Garcia NA, Dobos KM. Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection. Sci Rep. 2016 Nov 29;6:37975. doi: 10.1038/srep37975. PubMed PMID: 27897233; PubMed Central PMCID: PMC5126699.

Drolet BS, Reister-Hendricks LM, Podell BK, Breitenbach JE, McVey DS, van Rijn PA, Bowen RA. European Bluetongue Serotype 8: Disease Threat Assessment for U.S. Sheep. Vector Borne Zoonotic Dis. 2016 Jun;16(6):400-7. doi: 10.1089/vbz.2015.1924. PubMed PMID: 27111674.

Foster CL, Badlam J, De Groote MA, Chan ED. A 65-Year-Old Groundskeeper With High Fever, Pulmonary Nodules, and Thoracic Lymphadenopathy. Chest. 2016 Jun;149(6):e191-4. doi: 10.1016/j.chest.2015.12.035. PubMed PMID: 27287596.

Fujiwara PI, Olea-Popelka F. Editorial Commentary: Why It Is Important to Distinguish Mycobacterium bovis as a Causal Agent of Human Tuberculosis. Clin Infect Dis. 2016 Sep 1;63(5):602-3. doi: 10.1093/cid/ciw374. PubMed PMID: 27298331.

Goehring LS, Brandes K, Ashton LV, Wittenburg LA, Olea-Popelka FJ, Lunn DP, Soboll Hussey G. Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro. Equine Vet J. 2016 Nov 19. doi: 10.1111/evj.12656. [Epub ahead of print] PubMed PMID: 27864898.

Grover A, McLean JL, Troudt JM, Foster C, Izzo L, Creissen E, MacDonald E, Troy A, Izzo AA. Heat killed Saccharomyces cerevisiae as an adjuvant for the induction of vaccine-mediated immunity against infection with Mycobacterium tuberculosis. Vaccine. 2016 May 27;34(25):2798-805. doi: 10.1016/j.vaccine.2016.04.052. PubMed PMID: 27131285.

Grzegorzewicz AE, de Sousa-d’Auria C, McNeil MR, Huc-Claustre E, Jones V, Petit C, Angala SK, Zemanová J, Wang Q, Belardinelli JM, Gao Q, Ishizaki Y, Mikušová K, Brennan PJ, Ronning DR, Chami M, Houssin C, Jackson M. Assembling of the Mycobacterium tuberculosis Cell Wall Core. J Biol Chem. 2016 Sep 2;291(36):18867-79. doi: 10.1074/jbc.M116.739227. PubMed PMID: 27417139; PubMed Central PMCID: PMC5009262.

Hemphill DD, McIlwraith CW, Slayden RA, Samulski RJ, Goodrich LR. Adeno-associated virus gene therapy vector scAAVIGF-I for transduction of equine articular chondrocytes and RNA-seq analysis. Osteoarthritis Cartilage. 2016 May;24(5):902-11. doi: 10.1016/j.joca.2015.12.001. PubMed PMID: 26706703.

Henao-Tamayo MI, Obregón-Henao A, Arnett K, Shanley CA, Podell B, Orme IM, Ordway DJ. Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection. J Leukoc Biol. 2016 Apr;99(4):605-17. doi: 10.1189/jlb.4A0614-308RR. PubMed PMID: 26590147; PubMed Central PMCID: PMC4787291.

Irwin SM, Prideaux B, Lyon ER, Zimmerman MD, Brooks EJ, Schrupp CA, Chen C, Reichlen MJ, Asay BC, Voskuil MI, Nuermberger EL, Andries K, Lyons MA, Dartois V, Lenaerts AJ. Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice. ACS Infect Dis. 2016 Apr 8;2(4):251-267. PubMed PMID: 27227164; PubMed Central PMCID: PMC4874602.

Kiran D, Podell BK, Chambers M, Basaraba RJ. Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review. Semin Immunopathol. 2016 Mar;38(2):167-83. doi: 10.1007/s00281-015-0537-x. Review. PubMed PMID: 26510950; PubMed Central PMCID: PMC4779125.

Knudson SE, Cummings JE, Bommineni GR, Pan P, Tonge PJ, Slayden RA. Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis. Tuberculosis (Edinb). 2016 Dec;101:8-14. doi: 10.1016/j.tube.2016.07.016. PubMed PMID: 27865404; PubMed Central PMCID: PMC5117134.

Kochen MA, Chambers MC, Holman JD, Nesvizhskii AI, Weintraub ST, Belisle JT, Islam MN, Griss J, Tabb DL. Greazy: Open-Source Software for Automated Phospholipid Tandem Mass Spectrometry Identification. Anal Chem. 2016 Jun 7;88(11):5733-41. doi: 10.1021/acs.analchem.6b00021. PubMed PMID: 27186799; PubMed Central PMCID: PMC4996967.

Laurentius LB, Crawford AC, Mulvihill TS, Granger JH, Robinson R, Spencer JS, Chatterjee D, Hanson KE, Porter MD. Importance of specimen pretreatment for the low-level detection of mycobacterial lipoarabinomannan in human serum. Analyst. 2016 Dec 19;142(1):177-185. PubMed PMID: 27934985.

Li W, Obregón-Henao A, Wallach JB, North EJ, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M. Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5198-207. doi: 10.1128/AAC.00826-16. PubMed PMID: 27297488; PubMed Central PMCID: PMC4997843.

Linke LM, Wilusz J, Pabilonia KL, Fruehauf J, Magnuson R, Olea-Popelka F, Triantis J, Landolt G, Salman M. Inhibiting avian influenza virus shedding using a novel RNAi antiviral vector technology: proof of concept in an avian cell model. AMB Express. 2016 Mar;6(1):16. doi: 10.1186/s13568-016-0187-y. PubMed PMID: 26910902; PubMed Central PMCID: PMC4766140.

Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE. Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. PubMed PMID: 28081607.

Man DK, Chow MY, Casettari L, Gonzalez-Juarrero M, Lam JK. Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis. Adv Drug Deliv Rev. 2016 Jul 1;102:21-32. doi: 10.1016/j.addr.2016.04.013. Review. PubMed PMID: 27108702.

McLean JL, Suchman EL. Using Magnets and Classroom Flipping to Promote Student Engagement and Learning about Protein Translation in a Large Microbiology Class. J Microbiol Biol Educ. 2016 May 4;17(2):288-9. doi: 10.1128/jmbe.v17i2.1048. PubMed PMID: 27158313; PubMed Central PMCID: PMC4858368.

McLean JL, Suchman EL. Video Lecture Capture Technology Helps Students Study without Affecting Attendance in Large Microbiology Lecture Courses. J Microbiol Biol Educ. 2016 Dec 2;17(3):480-481. doi: 10.1128/jmbe.v17i3.1123. PubMed PMID: 28101280; PubMed Central PMCID: PMC5134957.

Miller M, Kruger M, Kruger M, Olea-Popelka F, Buss P. A SCORING SYSTEM TO IMPROVE DECISION MAKING AND OUTCOMES IN THE ADAPTATION OF RECENTLY CAPTURED WHITE RHINOCEROSES (CERATOTHERIUM SIMUM) TO CAPTIVITY. J Wildl Dis. 2016 Apr;52(2 Suppl):S78-85. doi: 10.7589/52.2S.S85. PubMed PMID: 26845302.

Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Amara RR, Plikaytis BB, Posey JE, Sable SB. Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis. Sci Rep. 2016 May 13;6:25837. doi: 10.1038/srep25837. PubMed PMID: 27173443; PubMed Central PMCID: PMC4865829.

Nieto R LM, Mehaffy C, Creissen E, Troudt J, Troy A, Bielefeldt-Ohmann H, Burgos M, Izzo A, Dobos KM. Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC. PLoS One. 2016 Nov 28;11(11):e0166807. doi: 10.1371/journal.pone.0166807. PubMed PMID: 27893795; PubMed Central PMCID: PMC5125630.

Nieto R LM, Mehaffy C, Dobos KM. Comparing isogenic strains of Beijing genotype Mycobacterium tuberculosis after acquisition of Isoniazid resistance: A proteomics approach. Proteomics. 2016 May;16(9):1376-80. doi: 10.1002/pmic.201500403. PubMed PMID: 26929115; PubMed Central PMCID: PMC50742.

Olea-Popelka F, Muwonge A, Perera A, Dean AS, Mumford E, Erlacher-Vindel E, Forcella S, Silk BJ, Ditiu L, El Idrissi A, Raviglione M, Cosivi O, LoBue P, Fujiwara PI. Zoonotic tuberculosis in human beings caused by Mycobacterium bovis-a call for action. Lancet Infect Dis. 2017 Jan;17(1):e21-e25. doi: 10.1016/S1473-3099(16)30139-6. Review. PubMed PMID: 27697390.

Orme IM. Vaccines to prevent tuberculosis infection rather than disease: Physiological and immunological aspects. Tuberculosis (Edinb). 2016 Dec;101:210-216. doi: 10.1016/j.tube.2014.10.008. Review. PubMed PMID: 25500316.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O’Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. PubMed PMID: 27503647; PubMed Central PMCID: PMC5038265.

Peters BJ, Groninger AS, Fontes FL, Crick DC, Crans DC. Differences in Interactions of Benzoic Acid and Benzoate with Interfaces. Langmuir. 2016 Sep 20;32(37):9451-9. doi: 10.1021/acs.langmuir.6b02073. PubMed PMID: 27482911.

Rakesh, Bruhn DF, Scherman MS, Singh AP, Yang L, Liu J, Lenaerts AJ, Lee RE. Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. Bioorg Med Chem Lett. 2016 Jan 15;26(2):388-91. doi: 10.1016/j.bmcl.2015.12.002. PubMed PMID: 26711150; PubMed Central PMCID: PMC4706794.

Robertson GT, Scherman MS, Bruhn DF, Liu J, Hastings C, McNeil MR, Butler MM, Bowlin TL, Lee RB, Lee RE, Lenaerts AJ. Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models. J Antimicrob Chemother. 2016 Dec 20. pii: dkw467. doi: 10.1093/jac/dkw467. [Epub ahead of print] PubMed PMID: 27999020.

Roset Bahmanyar E, Smith WC, Brennan P, Cummings R, Duthie M, Richardus JH, Saunderson P, Shwe T, Rosen S, Geluk A. Leprosy Diagnostic Test Development As a Prerequisite Towards Elimination: Requirements from the User’s Perspective. PLoS Negl Trop Dis. 2016 Feb 11;10(2):e0004331. doi: 10.1371/journal.pntd.0004331. PubMed PMID: 26866699; PubMed Central PMCID: PMC4750857.

Rotcheewaphan S, Belisle JT, Webb KJ, Kim HJ, Spencer JS, Borlee BR. Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c. Microbiology. 2016 Sep;162(9):1651-1661. doi: 10.1099/mic.0.000339. PubMed PMID: 27450520.

Salgado CG, Barreto JG, da Silva MB, Frade MA, Spencer JS. What do we actually know about leprosy worldwide? Lancet Infect Dis. 2016 Jul;16(7):778. doi: 10.1016/S1473-3099(16)30090-1. PubMed PMID: 27352757.

Schenk M, Mahapatra S, Le P, Kim HJ, Choi AW, Brennan PJ, Belisle JT, Modlin RL. Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae. Infect Immun. 2016 Aug 19;84(9):2429-38. doi: 10.1128/IAI.00334-16. PubMed PMID: 27297389; PubMed Central PMCID: PMC4995902.

Schrager LK, Izzo A, Velmurugan K. Immunopathogenesis of tuberculosis and novel mechanisms of vaccine activity. Tuberculosis (Edinb). 2016 Aug;99 Suppl 1:S3-7. doi: 10.1016/j.tube.2016.05.011. PubMed PMID: 27450395.

Sharpe S, White A, Sarfas C, Sibley L, Gleeson F, McIntyre A, Basaraba R, Clark S, Hall G, Rayner E, Williams A, Marsh PD, Dennis M. Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations. Tuberculosis (Edinb). 2016 Dec;101:174-190. doi: 10.1016/j.tube.2016.09.004. PubMed PMID: 27865390; PubMed Central PMCID: PMC5120991.

Silva CA, Webb K, Andre BG, Marques MA, de Carvalho FM, de Macedo CS, Pinheiro RO, Sarno EN, Pessolani MC, Belisle JT. Type 1 reaction in leprosy patients corresponds with a decrease in pro-resolving and an increase in pro-inflammatory lipid mediators. J Infect Dis. 2016 Dec 8. pii: jiw541. [Epub ahead of print] PubMed PMID: 27932613.

Soni I, De Groote MA, Dasgupta A, Chopra S. Challenges facing the drug discovery pipeline for non-tuberculous mycobacteria. J Med Microbiol. 2016 Jan;65(1):1-8. doi: 10.1099/jmm.0.000198. Review. PubMed PMID: 26515915.

Sukocheva OA, Manavis J, Kok TW, Turra M, Izzo A, Blumbergs P, Marmion BP. Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report. BMC Infect Dis. 2016 Apr 18;16:165. doi: 10.1186/s12879-016-1497-z. PubMed PMID: 27091026; PubMed Central PMCID: PMC4835832.

Sullivan K, Kerr K, Wanty R, Amaral B, Olea-Popelka F, Valdes E. Dietary management, husbandry, and body weights of African elephants (Loxodonta africana) during successful pregnancies at Disney’s Animal Kingdom. Zoo Biol. 2016 Nov;35(6):574-578. doi: 10.1002/zoo.21311. PubMed PMID: 27455912.

Tenne R, Sullivan LA, Contreras ET, Olea-Popelka F, Twedt DC, Fankhauser J, Mastrianna L, Lappin MR. Palatability and Clinical Effects of an Oral Recuperation Fluid During the Recovery of Dogs With Suspected Parvoviral Enteritis. Top Companion Anim Med. 2016 Jun;31(2):68-72. doi: 10.1053/j.tcam.2016.08.001. Review. PubMed PMID: 27968756.

Velezheva V, Brennan P, Ivanov P, Kornienko A, Lyubimov S, Kazarian K, Nikonenko B, Majorov K, Apt A. Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones. Bioorg Med Chem Lett. 2016 Feb 1;26(3):978-85. doi: 10.1016/j.bmcl.2015.12.049. PubMed PMID: 26725953.

Voge NV, Perera R, Mahapatra S, Gresh L, Balmaseda A, Loroño-Pino MA, Hopf-Jannasch AS, Belisle JT, Harris E, Blair CD, Beaty BJ. Metabolomics-Based Discovery of Small Molecule Biomarkers in Serum Associated with Dengue Virus Infections and Disease Outcomes. PLoS Negl Trop Dis. 2016 Feb 25;10(2):e0004449. doi: 10.1371/journal.pntd.0004449. PubMed PMID: 26913918; PubMed Central PMCID: PMC4768770.

Wang K, Langevin S, O’Hern CS, Shattuck MD, Ogle S, Forero A, Morrison J, Slayden R, Katze MG, Kirby M. Anomaly Detection in Host Signaling Pathways for the Early Prognosis of Acute Infection. PLoS One. 2016 Aug 17;11(8):e0160919. doi: 10.1371/journal.pone.0160919. PubMed PMID: 27532264; PubMed Central PMCID: PMC4988711.

Williams WR, Johnston MS, Higgins S, Izzo AA, Kendall LV. Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus). Lab Anim (NY). 2016 Jan;45(1):35-41. doi: 10.1038/laban.911. PubMed PMID: 26684957.

Wilson WJ, Afzali MF, Cummings JE, Legare ME, Tjalkens RB, Allen CP, Slayden RA, Hanneman WH. Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei. PLoS Negl Trop Dis. 2016 Oct 28;10(10):e0005065. doi: 10.1371/journal.pntd.0005065. PubMed PMID: 27792775; PubMed Central PMCID: PMC5085046.

Xia M, Hesser DC, De P, Sakala IG, Spencer CT, Kirkwood JS, Abate G, Chatterjee D, Dobos KM, Hoft DF. A Subset of Protective γ9δ2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components. Infect Immun. 2016 Aug 19;84(9):2449-62. doi: 10.1128/IAI.01322-15. PubMed PMID: 27297390; PubMed Central PMCID: PMC4995917.

Zelmer A, Tanner R, Stylianou E, Damelang T, Morris S, Izzo A, Williams A, Sharpe S, Pepponi I, Walker B, Hokey DA, McShane H, Brennan M, Fletcher H. A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis. BMC Infect Dis. 2016 Aug 12;16:412. doi: 10.1186/s12879-016-1751-4. PubMed PMID: 27519524; PubMed Central PMCID: PMC4983071.

Bai X, Kinney WH, Su WL, Bai A, Ovrutsky AR, Honda JR, Netea MG, Henao-Tamayo M, Ordway DJ, Dinarello CA, Chan ED. Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells. BMC Microbiol. 2015 Feb 21;15:39. doi: 10.1186/s12866-015-0366-z. PubMed PMID: 25887904; PubMed Central PMCID: PMC4349755.

Bai X, Shang S, Henao-Tamayo M, Basaraba RJ, Ovrutsky AR, Matsuda JL, Takeda K, Chan MM, Dakhama A, Kinney WH, Trostel J, Bai A, Honda JR, Achcar R, Hartney J, Joosten LA, Kim SH, Orme I, Dinarello CA, Ordway DJ, Chan ED. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5111-6. doi: 10.1073/pnas.1424302112. PubMed PMID: 25820174; PubMed Central PMCID: PMC4413346.

Baldwin SL, Reese VA, Huang PW, Beebe EA, Podell BK, Reed SG, Coler RN. Protection and Long-Lived Immunity Induced by the ID93/GLA-SE Vaccine Candidate against a Clinical Mycobacterium tuberculosis Isolate. Clin Vaccine Immunol. 2015 Dec 9;23(2):137-47. doi: 10.1128/CVI.00458-15. PubMed PMID: 26656121; PubMed Central PMCID: PMC4744918.

Barreto JG, Bisanzio D, Frade MA, Moraes TM, Gobbo AR, de Souza Guimarães L, da Silva MB, Vazquez-Prokopec GM, Spencer JS, Kitron U, Salgado CG. Spatial epidemiology and serologic cohorts increase the early detection of leprosy. BMC Infect Dis. 2015 Nov 16;15:527. doi: 10.1186/s12879-015-1254-8. PubMed PMID: 26573912; PubMed Central PMCID: PMC4647818.

Bishwakarma R, Kinney WH, Honda JR, Mya J, Strand MJ, Gangavelli A, Bai X, Ordway DJ, Iseman MD, Chan ED. Epidemiologic link between tuberculosis and cigarette/biomass smoke exposure: Limitations despite the vast literature. Respirology. 2015 May;20(4):556-68. doi: 10.1111/resp.12515. Review. PubMed PMID: 25808744.

Brown VR, Adney DR, Olea-Popelka F, Bowen RA. Prior Inoculation with Type B Strains of Francisella tularensis Provides Partial Protection against Virulent Type A Strains in Cottontail Rabbits. PLoS One. 2015 Oct 16;10(10):e0140723. doi: 10.1371/journal.pone.0140723. PubMed PMID: 26474413; PubMed Central PMCID: PMC4608750.

Brown VR, Adney DR, Bielefeldt-Ohmann H, Gordy PW, Felix TA, Olea-Popelka FJ, Bowen RA. PATHOGENESIS AND IMMUNE RESPONSES OF FRANCISELLA TULARENSIS STRAINS IN
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Bruhn DF, Scherman MS, Liu J, Scherbakov D, Meibohm B, Böttger EC, Lenaerts AJ, Lee RE. In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics. Sci Rep. 2015 Sep 14;5:13985. doi: 10.1038/srep13985. PubMed PMID: 26365087; PubMed Central PMCID:PMC4568539.

Chamberlain LM, Holt-Casper D, Gonzalez-Juarrero M, Grainger DW. Extended culture of macrophages from different sources and maturation results in a common M2 phenotype. J Biomed Mater Res A. 2015 Sep;103(9):2864-74. doi: 10.1002/jbm.a.35415. PubMed PMID: 25684281; PubMed Central PMCID: PMC4520783.

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Kim HJ, Brennan PJ, Heaslip D, Udey MC, Modlin RL, Belisle JT. Carbohydrate-dependent binding of langerin to SodC, a cell wall glycoprotein of Mycobacterium leprae. J Bacteriol. 2015 Feb;197(3):615-25. doi: 10.1128/JB.02080-14. PubMed PMID: 25422308; PubMed Central PMCID: PMC4285976.

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Kruh JN, Kruh-Garcia NA, Foster CS. Evaluation of the Effect of N-Acetylcysteine on Protein Deposition on Contact Lenses in Patients with the Boston Keratoprosthesis Type I. J Ocul Pharmacol Ther. 2015 Jul-Aug;31(6):314-22. doi: 10.1089/jop.2015.0010. PubMed PMID: 26133055.

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Kuznetsov I, Filevich J, Dong F, Woolston M, Chao W, Anderson EH, Bernstein ER, Crick DC, Rocca JJ, Menoni CS. Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry. Nat Commun. 2015 Apr 23;6:6944. doi: 10.1038/ncomms7944. PubMed PMID: 25903827; PubMed Central PMCID: PMC4423227.

Lanoix JP, Lenaerts AJ, Nuermberger EL. Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis. Dis Model Mech. 2015 Jun;8(6):603-10. doi: 10.1242/dmm.019513. PubMed PMID: 26035868; PubMed Central PMCID: PMC4457036.

Larrouy-Maumus G, Gilleron M, Skovierová H, Zuberogoitia S, Brennan PJ, Puzo G, Jackson M, Nigou J. A glycomic approach reveals a new mycobacterial polysaccharide. Glycobiology. 2015 Nov;25(11):1163-71. doi: 10.1093/glycob/cwv061. PubMed PMID: 26261090; PubMed Central PMCID: PMC4594620.

Lenaerts A, Barry CE 3rd, Dartois V. Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol Rev. 2015 Mar;264(1):288-307. doi: 10.1111/imr.12252. Review. PubMed PMID: 25703567; PubMed Central PMCID: PMC4368385.

Li K, Wang Y, Yang G, Byun S, Rao G, Shoen C, Yang H, Gulati A, Crick DC, Cynamon M, Huang G, Docampo R, No JH, Oldfield E. Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors. ACS Infect Dis. 2015 May 8;1(5):215-221. PubMed PMID: 26258172; PubMed Central PMCID: PMC4527605.

Li SY, Irwin SM, Converse PJ, Mdluli KE, Lenaerts AJ, Nuermberger EL. Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models. Antimicrob Agents Chemother. 2015 Jul;59(7):4026-30. doi: 10.1128/AAC.00105-15. PubMed PMID: 25918146; PubMed Central PMCID: PMC4468727.

Lucas MC, Wolfe LM, Hazenfield RM, Kurihara J, Kruh-Garcia NA, Belisle J, Dobos KM. Fractionation and analysis of mycobacterial proteins. Methods Mol Biol. 2015;1285:47-75. doi: 10.1007/978-1-4939-2450-9_4. PubMed PMID: 25779310.

Lyons MA, Lenaerts AJ. Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model. J Pharmacokinet Pharmacodyn. 2015 Aug;42(4):375-89. doi: 10.1007/s10928-015-9419-z. PubMed PMID: 26026426; PubMed Central PMCID: PMC4506877.

Marques MA, Berrêdo-Pinho M, Rosa TL, Pujari V, Lemes RM, Lery LM, Silva CA, Guimarães AC, Atella GC, Wheat WH, Brennan PJ, Crick DC, Belisle JT, Pessolani MC. The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production. J Bacteriol. 2015 Dec;197(23):3698-707. doi: 10.1128/JB.00625-15. PubMed PMID: 26391209; PubMed Central PMCID: PMC4626898

Miller M, Buss P, Wanty R, Parsons S, van Helden P, Olea-Popelka F. Baseline Hematologic Results for Free-ranging White Rhinoceros (Ceratotherium simum) in Kruger National Park, South Africa. J Wildl Dis. 2015 Oct;51(4):916-22. doi:10.7589/2015-03-081. PubMed PMID: 26267457.

Molins CR, Ashton LV, Wormser GP, Hess AM, Delorey MJ, Mahapatra S, Schriefer ME, Belisle JT. Development of a metabolic biosignature for detection of early Lyme disease. Clin Infect Dis. 2015 Jun 15;60(12):1767-75. doi: 10.1093/cid/civ185. PubMed PMID: 25761869; PubMed Central PMCID: PMC481080.

Obregón-Henao A, Arnett KA, Henao-Tamayo M, Massoudi L, Creissen E, Andries K, Lenaerts AJ, Ordway DJ. Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models. Antimicrob Agents Chemother. 2015 Nov;59(11):6904-12. doi: 10.1128/AAC.00459-15. PubMed PMID: 26303795; PubMed Central PMCID: PMC4604395.

Orme IM. Tuberculosis vaccine types and timings. Clin Vaccine Immunol. 2015 Mar;22(3):249-57. doi: 10.1128/CVI.00718-14. Review. PubMed PMID: 25540272; PubMed Central PMCID: PMC4340897.

Orme IM, Robinson RT, Cooper AM. The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol. 2015 Jan;16(1):57-63. doi: 10.1038/ni.3048. Review. PubMed PMID: 25521685.

Passamonti F, Vardi DM, Stefanetti V, Marenzoni ML, Prato S, Cévese P, Coletti M, Pepe M, Casagrande Proietti P, Olea-Popelka F. Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice. Vet J. 2015 Feb;203(2):211-8. doi: 10.1016/j.tvjl.2014.08.033. PubMed PMID: 25555337.

Randall LB, Dobos K, Papp-Wallace KM, Bonomo RA, Schweizer HP. Membrane-Bound PenA β-Lactamase of Burkholderia pseudomallei. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1509-14. doi: 10.1128/AAC.02444-15. PubMed PMID: 26711764; PubMed Central PMCID: PMC4775993.

Richardson MA, Furlani RE, Podell BK, Ackart DF, Haugen JD, Melander RJ, Melander C, Basaraba RJ. Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. Tetrahedron Lett. 2015;56(23):3406-3409. PubMed PMID: 26146419; PubMed Central PMCID: PMC4487526.

Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC. Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ. ACS Cent Sci. 2015 Sep 23;1(6):292-302. PubMed PMID: 26436137; PubMed Central PMCID: PMC4582327.

Via LE, Savic R, Weiner DM, Zimmerman MD, Prideaux B, Irwin SM, Lyon E, O’Brien P, Gopal P, Eum S, Lee M, Lanoix JP, Dutta NK, Shim T, Cho JS, Kim W, Karakousis PC, Lenaerts A, Nuermberger E, Barry CE 3rd, Dartois V. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives. ACS Infect Dis. 2015 May 8;1(5):203-214. PubMed PMID: 26086040; PubMed Central PMCID: PMC4467917.

Wang Q, Zhu L, Jones V, Wang C, Hua Y, Shi X, Feng X, Jackson M, Niu C, Gao Q. CpsA, a LytR-CpsA-Psr Family Protein in Mycobacterium marinum, Is Required for Cell Wall Integrity and Virulence. Infect Immun. 2015 Jul;83(7):2844-54. doi: 10.1128/IAI.03081-14. PubMed PMID: 25939506; PubMed Central PMCID: PMC4468561.

Wheat WH, Dhouib R, Angala SK, Larrouy-Maumus G, Dobos K, Nigou J, Spencer JS, Jackson M. The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10. Tuberculosis (Edinb). 2015 Jul;95(4):476-89. doi: 10.1016/j.tube.2015.04.002. PubMed PMID: 26048627; PubMed Central PMCID: PMC4475442.

Williams MJ, Shanley CA, Zilavy A, Peixoto B, Manca C, Kaplan G, Orme IM, Mizrahi V, Kana BD. bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs. Infect Immun. 2015 Feb;83(2):544-50. doi: 10.1128/IAI.02722-14. PubMed PMID: 25404027; PubMed Central PMCID: PMC4294236.

Yu CH, Micaroni M, Puyskens A, Schultz TE, Yeo JC, Stanley AC, Lucas M, Kurihara J, Dobos KM, Stow JL, Blumenthal A. RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection. J Immunol. 2015 Oct 15;195(8):3890-900. doi: 10.4049/jimmunol.1500017. PubMed PMID: 26371254.

Ackart DF, Hascall-Dove L, Caceres SM, Kirk NM, Podell BK, Melander C, Orme IM, Leid JG, Nick JA, Basaraba RJ. Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. Pathog Dis. 2014 Apr;70(3):359-69. doi: 10.1111/2049-632X.12144. Epub 2014 Feb 24. PubMed PMID: 24478060.

Ackart DF, Lindsey EA, Podell BK, Melander RJ, Basaraba RJ, Melander C. Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules. Pathog Dis. 2014 Apr;70(3):370-8. doi: 10.1111/2049-632X.12143. Epub 2014 Feb 24. PubMed PMID: 24478046.

Adams AE, Olea-Popelka FJ, Grandin T, Woerner DR, Roman-Muniz IN. Dairy cow handling facilities and the perception of Beef Quality Assurance on Colorado dairies. J Dairy Sci. 2014 Feb;97(2):798-804. doi: 10.3168/jds.2013-7146. Epub 2013 Dec 15. PubMed PMID: 24342695.

Aiyaz M, Bipin C, Pantulwar V, Mugasimangalam R, Shanley CA, Ordway DJ, Orme IM. Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372. Tuberculosis (Edinb). 2014 Oct 13. pii: S1472-9792(14)20491-4. doi: 10.1016/j.tube.2014.10.001. [Epub ahead of print] PubMed PMID: 25423882.

Aiyaz M, Bipin C, Pantulwar V, Mugasimangalam R, Shanley CA, Ordway DJ, Orme IM. Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372. Tuberculosis (Edinb). 2014 Dec;94(6):606-15. PubMed PMID: 25621360.

Angala SK, Belardinelli JM, Huc-Claustre E, Wheat WH, Jackson M. The cell envelope glycoconjugates of Mycobacterium tuberculosis. Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):361-99. doi: 10.3109/10409238.2014.925420. Epub 2014 Jun 10. PubMed PMID: 24915502.

Barreto JG, Bisanzio D, Guimarães Lde S, Spencer JS, Vazquez-Prokopec GM, Kitron U, Salgado CG. Spatial analysis spotlighting early childhood leprosy transmission in a hyperendemic municipality of the Brazilian Amazon region. PLoS Negl Trop Dis. 2014 Feb 6;8(2):e2665. doi: 10.1371/journal.pntd.0002665. eCollection 2014 Feb. PubMed PMID: 24516679; PubMed Central PMCID: PMC3916250.

Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI. Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence. MBio. 2014 Jun 3;5(3):e01106-14. doi: 10.1128/mBio.01106-14. PubMed PMID: 24895305; PubMed Central PMCID: PMC4049101.

Belardinelli JM, Larrouy-Maumus G, Jones V, Sorio de Carvalho LP, McNeil MR, Jackson M. Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis. J Biol Chem. 2014 Oct 3;289(40):27952-65. doi: 10.1074/jbc.M114.581199. Epub 2014 Aug 14. PubMed PMID: 25124040; PubMed Central PMCID: PMC4183827.

Bobosha K, Tjon Kon Fat EM, van den Eeden SJ, Bekele Y, van der Ploeg-van Schip JJ, de Dood CJ, Dijkman K, Franken KL, Wilson L, Aseffa A, Spencer JS, Ottenhoff TH, Corstjens PL, Geluk A. Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. PLoS Negl Trop Dis. 2014 May 8;8(5):e2845. doi: 10.1371/journal.pntd.0002845. eCollection 2014 May. PubMed PMID: 24810599; PubMed Central PMCID: PMC4014418.

Calado Nogueira de Moura V, Gibbs S, Jackson M. Gene replacement in Mycobacterium chelonae: application to the construction of porin knock-out mutants. PLoS One. 2014 Apr 16;9(4):e94951. doi: 10.1371/journal.pone.0094951. eCollection 2014. PubMed PMID: 24739882; PubMed Central PMCID: PMC3989263.

Capodagli GC, Sedhom WG, Jackson M, Ahrendt KA, Pegan SD. A noncompetitive inhibitor for Mycobacterium tuberculosis’s class IIa fructose 1,6-bisphosphate aldolase. Biochemistry. 2014 Jan 14;53(1):202-13. doi: 10.1021/bi401022b. Epub 2013 Dec 24. PubMed PMID: 24325645; PubMed Central PMCID: PMC4167715.

Chan ED, Kinney WH, Honda JR, Bishwakarma R, Gangavelli A, Mya J, Bai X, Ordway DJ. Tobacco exposure and susceptibility to tuberculosis: is there a smoking gun? Tuberculosis (Edinb). 2014 Dec;94(6):544-50. doi: 10.1016/j.tube.2014.08.010. Epub 2014 Sep 28. PubMed PMID: 25305002.

Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, Guo RT. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J Am Chem Soc. 2014 Feb 19;136(7):2892-6. doi: 10.1021/ja413127v. Epub 2014 Feb 5. PubMed PMID: 24475925; PubMed Central PMCID: PMC3986019.

Correa AF, Bailão AM, Bastos IM, Orme IM, Soares CM, Kipnis A, Santana JM, Junqueira-Kipnis AP. The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection. Infect Immun. 2014 Dec;82(12):5154-65. doi: 10.1128/IAI.02304-14. Epub 2014 Sep 29. PubMed PMID: 25267836; PubMed Central PMCID: PMC4249283.

Daffé M, Crick DC, Jackson M. Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids. Microbiol Spectr. 2014;2(4). pii: 14. PubMed PMID: 25485178; PubMed Central PMCID: PMC4255156.

De Groote MA, Gibbs S, de Moura VC, Burgess W, Richardson K, Kasperbauer S, Madinger N, Jackson M. Analysis of a panel of rapidly growing mycobacteria for resistance to aldehyde-based disinfectants. Am J Infect Control. 2014 Aug;42(8):932-4. doi: 10.1016/j.ajic.2014.05.014. PubMed PMID: 25087149; PubMed Central PMCID: PMC4121594.

De Groote MA, Johnson L, Podell B, Brooks E, Basaraba R, Gonzalez-Juarrero M. GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus. J Antimicrob Chemother. 2014 Apr;69(4):1057-64. doi: 10.1093/jac/dkt451. Epub 2013 Nov 11. PubMed PMID: 24222613.

Esparza-Gonzalez SC, Troy AR, Izzo AA. Comparative analysis of Bacillus subtilis spores and monophosphoryl lipid A as adjuvants of protein-based mycobacterium tuberculosis-based vaccines: partial requirement for interleukin-17a for induction of protective immunity. Clin Vaccine Immunol. 2014 Apr;21(4):501-8. doi: 10.1128/CVI.00622-13. Epub 2014 Jan 29. PubMed PMID: 24477855; PubMed Central PMCID: PMC3993107.

Fletcher, D.M., M.B. Vogt, H.E. Pirner, A.M. Hess, R.A. Bowen, M. Henao-Tamayo, and T.M. Eckstein. 2013 Flow cytometry baseline on peripheral leukocyte cell profiles for dairy goat kids.  Am. J. Anim.  Vet. Sci. 8:177-189.

Forrellad MA, McNeil M, Santangelo Mde L, Blanco FC, García E, Klepp LI, Huff J, Niederweis M, Jackson M, Bigi F. Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2014 Mar;94(2):170-7. doi: 10.1016/j.tube.2013.12.005. Epub 2014 Jan 2. PubMed PMID: 24440549; PubMed Central PMCID: PMC3951760.

Grover A, Troudt J, Foster C, Basaraba R, Izzo A. High mobility group box 1 acts as an adjuvant for tuberculosis subunit vaccines. Immunology. 2014 May;142(1):111-23. doi: 10.1111/imm.12236. PubMed PMID: 24350616; PubMed Central PMCID: PMC3992053.

Hagge DA, Scollard DM, Ray NA, Marks VT, Deming AT, Spencer JS, Adams LB. IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy. PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3149. doi: 10.1371/journal.pntd.0003149. eCollection 2014 Sep. PubMed PMID: 25210773; PubMed Central PMCID: PMC4161319.

Henao-Tamayo M, Obregón-Henao A, Creissen E, Shanley C, Orme I, Ordway DJ. Differential Mycobacterium bovis BCG Vaccine-Derived Efficacy in C3Heb/FeJ and C3H/HeOuJ Mice Exposed to a Clinical Strain of Mycobacterium tuberculosis. Clin Vaccine Immunol. 2015 Jan;22(1):91-8. doi: 10.1128/CVI.00466-14. Epub 2014 Nov 12. PubMed PMID: 25392011; PubMed Central PMCID: PMC4278923.

Henao-Tamayo M, Ordway DJ, Orme IM. Memory T cell subsets in tuberculosis: what should we be targeting? Tuberculosis (Edinb). 2014 Sep;94(5):455-61. doi: 10.1016/j.tube.2014.05.001. Epub 2014 Jun 17. PubMed PMID: 24993316.

Humphrey HM, Orloski KA, Olea-Popelka FJ. Bovine tuberculosis slaughter surveillance in the United States 2001-2010: assessment of its traceback investigation function. BMC Vet Res. 2014 Aug 15;10(1):182. doi: 10.1186/s12917-014-0182-y. PubMed PMID: 25123050; PubMed Central PMCID: PMC4145249.

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North EJ, Jackson M, Lee RE. New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics. Curr Pharm Des. 2014;20(27):4357-78. PubMed PMID: 24245756.

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Orme IM, Basaraba RJ. The formation of the granuloma in tuberculosis infection. Semin Immunol. 2014 Oct 22;26(6):601-609. doi: 10.1016/j.smim.2014.09.009. [Epub ahead of print] Review. PubMed PMID: 25453231.

Orme IM. Vaccines to prevent tuberculosis infection rather than disease: Physiological and immunological aspects. Tuberculosis (Edinb). 2014 Nov 27. pii: S1472-9792(14)20550-6. doi: 10.1016/j.tube.2014.10.008. [Epub ahead of print] Review. PubMed PMID: 25500316.

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Orme IM. Tuberculosis vaccines: types and timings. Clin Vaccine Immunol. 2014 Dec 24. pii: CVI.00718-14. [Epub ahead of print] PubMed PMID: 25540272.

Orme IM, Robinson RT, Cooper AM. The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol. 2014 Dec 18;16(1):57-63. doi: 10.1038/ni.3048. Review. PubMed PMID: 25521685.

Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy. ChemMedChem. 2014 Apr;9(4):776-91. doi: 10.1002/cmdc.201300429. Epub 2014 Mar 11. PubMed PMID: 24616444; PubMed Central PMCID: PMC4126670.

Park B, Awasthi D, Chowdhury SR, Melief EH, Kumar K, Knudson SE, Slayden RA, Ojima I. Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Bioorg Med Chem. 2014 May 1;22(9):2602-12. doi: 10.1016/j.bmc.2014.03.035. Epub 2014 Apr 1. PubMed PMID: 24726304; PubMed Central PMCID: PMC4045703.

Perley CC, Frahm M, Click EM, Dobos KM, Ferrari G, Stout JE, Frothingham R. The human antibody response to the surface of Mycobacterium tuberculosis. PLoS One. 2014 Jun 11;9(2):e98938. doi: 10.1371/journal.pone.0098938. eCollection 2014. PubMed PMID: 24918450; PubMed Central PMCID: PMC4053328.

Podell BK, Ackart DF, Obregon-Henao A, Eck SP, Henao-Tamayo M, Richardson M, Orme IM, Ordway DJ, Basaraba RJ. Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity. Am J Pathol. 2014 Apr;184(4):1104-18. doi: 10.1016/j.ajpath.2013.12.015. Epub 2014 Jan 31. PubMed PMID: 24492198; PubMed Central PMCID: PMC3969993.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog. 2014 May 22;10(5):e1004144. doi: 10.1371/journal.ppat.1004144. eCollection 2014 May. PubMed PMID: 24851864; PubMed Central PMCID: PMC4031216.

Rakesh, Bruhn DF, Scherman MS, Woolhiser LK, Madhura DB, Maddox MM, Singh AP, Lee RB, Hurdle JG, McNeil MR, Lenaerts AJ, Meibohm B, Lee RE. Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. PLoS One. 2014 Feb 5;9(2):e87909. doi: 10.1371/journal.pone.0087909. eCollection 2014. PubMed PMID: 24505329; PubMed Central PMCID: PMC3914891.

Rivoire BL, Groathouse NA, TerLouw S, Neupane KD, Ranjit C, Sapkota BR, Khadge S, Kunwar CB, Macdonald M, Hawksworth R, Thapa MB, Hagge DA, Tibbals M, Smith C, Dube T, She D, Wolff M, Zhou E, Makhene M, Mason R, Sizemore C, Brennan PJ. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study. PLoS Negl Trop Dis. 2014 May 29;8(5):e2811. doi: 10.1371/journal.pntd.0002811. eCollection 2014. PubMed PMID: 24874401; PubMed Central PMCID: PMC4038488.

Rivoire BL, TerLouw S, Groathouse NA, Brennan PJ. The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy. PLoS Negl Trop Dis. 2014 May 29;8(5):e2791. doi: 10.1371/journal.pntd.0002791. eCollection 2014. PubMed PMID: 24874086; PubMed Central PMCID: PMC4038479.

Ryan GJ, Shapiro HM, Lenaerts AJ. Improving acid-fast fluorescent staining for the detection of mycobacteria using a new nucleic acid staining approach. Tuberculosis (Edinb). 2014 Sep;94(5):511-8. doi: 10.1016/j.tube.2014.07.004. Epub 2014 Jul 28. PubMed PMID: 25130623.

Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, Sotriffer CA, Tonge PJ, Kisker C. Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. J Biol Chem. 2014 Jun 6;289(23):15987-6005. doi: 10.1074/jbc.M113.532804. Epub 2014 Apr 16. PubMed PMID: 24739388; PubMed Central PMCID: PMC4047375.

Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA. Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. EMBO Mol Med. 2014 Dec 22. pii: e201404137. doi: 10.15252/emmm.201404137. [Epub ahead of print] PubMed PMID: 25535254.

Shanley CA, Ireton GC, Baldwin SL, Coler RN, Reed SG, Basaraba RJ, Orme IM. Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2014 Mar;94(2):140-7. doi: 10.1016/j.tube.2013.08.010. Epub 2013 Sep 7. PubMed PMID: 24295653; PubMed Central PMCID: PMC3944893.

Shi L, Ryan GJ, Bhamidi S, Troudt J, Amin A, Izzo A, Lenaerts AJ, McNeil MR, Belisle JT, Crick DC, Chatterjee D. Isolation and purification of Mycobacterium tuberculosis from H37Rv infected guinea pig lungs. Tuberculosis (Edinb). 2014 Sep;94(5):525-30. doi: 10.1016/j.tube.2014.05.003. Epub 2014 Jun 30. PubMed PMID: 25037320.

Shikani AH, Sidhaye VK, Basaraba RJ, Shikani HJ, Alqudah MA, Kirk N, Cope E, Leid JG. Mucosal expression of aquaporin 5 and epithelial barrier proteins in chronic rhinosinusitis with and without nasal polyps. Am J Otolaryngol. 2014 May-Jun;35(3):377-83. doi: 10.1016/j.amjoto.2013.11.011. Epub 2013 Dec 7. PubMed PMID: 24612929.

Svetlíková Z, Baráth P, Jackson M, Korduláková J, Mikušová K. Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid- monoacylated phosphatidylinositol dimannoside. Protein Expr Purif. 2014 Aug;100:33-9. doi: 10.1016/j.pep.2014.04.014. Epub 2014 May 6. PubMed PMID: 24810911; PubMed Central PMCID: PMC4099486.

Tettelin H, Davidson RM, Agrawal S, Aitken ML, Shallom S, Hasan NA, Strong M, de Moura VC, De Groote MA, Duarte RS, Hine E, Parankush S, Su Q, Daugherty SC, Fraser CM, Brown-Elliott BA, Wallace RJ Jr, Holland SM, Sampaio EP, Olivier KN, Jackson M, Zelazny AM. High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks. Emerg Infect Dis. 2014 Mar;20(3):364-71. doi: 10.3201/eid2003.131106. PubMed PMID: 24565502; PubMed Central PMCID: PMC3944860.

Wheat WH, Casali AL, Thomas V, Spencer JS, Lahiri R, Williams DL, McDonnell GE, Gonzalez-Juarrero M, Brennan PJ, Jackson M. Long-term Survival and Virulence  of Mycobacterium leprae in Amoebal Cysts. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3405. doi: 10.1371/journal.pntd.0003405. eCollection 2014 Dec. PubMed PMID: 25521850; PubMed Central PMCID: PMC4270725.

Wieczorek AE, Troudt JL, Knabenbauer P, Taylor J, Pavlicek RL, Karls R, Hess  A, Davidson RM, Strong M, Bielefeldt-Ohmann H, Izzo AA, Dobos KM. HspX vaccination and role in virulence in the guinea pig model of tuberculosis. Pathog Dis. 2014 Aug;71(3):315-25. doi: 10.1111/2049-632X.12147. Epub 2014 Feb 24. PubMed PMID: 24616427; PubMed Central PMCID: PMC4130790.

Williams MJ, Shanley CA, Zilavy A, Peixoto B, Manca C, Kaplan G, Orme IM, Mizrahi V, Kana BD. bis-Molybdopterin Guanine Dinucleotide Is Required for Persistence of Mycobacterium tuberculosis in Guinea Pigs. Infect Immun. 2015 Feb;83(2):544-50. doi: 10.1128/IAI.02722-14. Epub 2014 Nov 17. PubMed PMID: 25404027.

Yang L, Lu S, Belardinelli J, Huc-Claustre E, Jones V, Jackson M, Zgurskaya HI. RND transporters protect Corynebacterium glutamicum from antibiotics by assembling the outer membrane. Microbiologyopen. 2014 Aug;3(4):484-96. doi: 10.1002/mbo3.182. Epub 2014 Jun 18. PubMed PMID: 24942069; PubMed Central PMCID:  PMC4287177.

Adams AE, Olea-Popelka FJ, Roman-Muniz IN. Using temperature-sensing reticular boluses to aid in the detection of production diseases in dairy cows. J Dairy Sci. 2013 Mar;96(3):1549-55. doi: 10.3168/jds.2012-5822. Epub 2013 Jan 16. PubMed PMID: 23332847.

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Awasthi D, Kumar K, Knudson SE, Slayden RA, Ojima I. SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents. J Med Chem. 2013 Dec 12;56(23):9756-70. doi: 10.1021/jm401468w. Epub 2013 Nov 23. PubMed PMID: 24266862; PubMed Central PMCID: PMC3933301.

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Beam AL, Thilmany DD, Garber LP, Van Metre DC, Pritchard RW, Kopral CA, Olea-Popelka FJ. Factors affecting use of veterinarians by small-scale food animal operations. J Am Vet Med Assoc. 2013 Nov 1;243(9):1334-44. doi: 10.2460/javma.243.9.1334. PubMed PMID: 24134586.

Booysen LL, Kalombo L, Brooks E, Hansen R, Gilliland J, Gruppo V, Lungenhofer P, Semete-Makokotlela B, Swai HS, Kotze AF, Lenaerts A, du Plessis LH. In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid. Int J Pharm. 2013 Feb 28;444(1-2):10-7. doi: 10.1016/j.ijpharm.2013.01.038. Epub 2013 Jan 26. PubMed PMID: 23357255.

Brennan PJ, Brosch R, Birren B, Sobral B. TBCAP; tuberculosis annotation project. Tuberculosis (Edinb). 2013 Jan;93(1):1-5. doi: 10.1016/j.tube.2012.11.013. Epub 2013 Jan 16. PubMed PMID: 23332402.

Cardona-Castro N, Beltrán-Alzate JC, Romero-Montoya IM, Li W, Brennan PJ, Vissa V. Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography. Infect Genet Evol. 2013 Mar;14:375-82. doi: 10.1016/j.meegid.2012.12.015. Epub 2013 Jan 3. PubMed PMID: 23291420; PubMed Central PMCID: PMC3668693.

Cayabyab MJ, Qin L, Kashino SS, Izzo A, Campos-Neto A. An unbiased peptide-wide discovery approach to select Mycobacterium tuberculosis antigens that target CD8+ T cell response during infection. Vaccine. 2013 Oct 1;31(42):4834-40. doi: 10.1016/j.vaccine.2013.07.077. Epub 2013 Aug 9. PubMed PMID: 23933335; PubMed Central PMCID: PMC3778375.

Cui P, Vissa V, Li W, Zhang X, Lin L, Wang H, Liu X, Wu Q, Zong W. Cutaneous  Mycobacterium shigaense infection in immunocompetent Woman, China. Emerg Infect Dis. 2013 May;19(5):819-20. doi: 10.3201/eid1905.121022. PubMed PMID: 23697461; PubMed Central PMCID: PMC3647498.

Davidson RM, Hasan NA, de Moura VC, Duarte RS, Jackson M, Strong M. Phylogenomics of Brazilian epidemic isolates of Mycobacterium abscessus subsp. bolletii reveals relationships of global outbreak strains. Infect Genet Evol. 2013 Dec;20:292-7. doi: 10.1016/j.meegid.2013.09.012. Epub 2013 Sep 18. PubMed PMID: 24055961; PubMed Central PMCID: PMC3853122.

Davidson RM, Reynolds PR, Farias-Hesson E, Duarte RS, Jackson M, Strong M. Genome Sequence of an Epidemic Isolate of Mycobacterium abscessus subsp. Bolletii from Rio de Janeiro, Brazil. Genome Announc. 2013 Aug 15;1(4). pii: e00617-13. doi: 10.1128/genomeA.00617-13. PubMed PMID: 23950125; PubMed Central PMCID: PMC3744681.

de Léséleuc L, Orlova M, Cobat A, Girard M, Huong NT, Ba NN, Thuc NV, Truman R, Spencer JS, Adams L, Thai VH, Alcais A, Schurr E. PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages. PLoS Negl Trop Dis. 2013;7(1):e2015. doi: 10.1371/journal.pntd.0002015. Epub 2013 Jan 17. PubMed PMID: 23350010; PubMed Central PMCID: PMC3547867.

Deshayes C, Angala SK, Marion E, Brandli I, Babonneau J, Preisser L, Eyangoh  S, Delneste Y, Legras P, De Chastellier C, Stinear TP, Jackson M, Marsollier L. Regulation of mycolactone, the Mycobacterium ulcerans toxin, depends on nutrient source. PLoS Negl Trop Dis. 2013 Nov 14;7(11):e2502. doi: 10.1371/journal.pntd.0002502. eCollection 2013 Nov. PubMed PMID: 24244764; PubMed Central PMCID: PMC3828164.

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Favrot L, Grzegorzewicz AE, Lajiness DH, Marvin RK, Boucau J, Isailovic D, Jackson M, Ronning DR. Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun. 2013;4:2748. doi: 10.1038/ncomms3748. PubMed PMID: 24193546; PubMed Central PMCID: PMC4049535.

Gonzalez-Juarrero M, Bosco-Lauth A, Podell B, Soffler C, Brooks E, Izzo A, Sanchez-Campillo J, Bowen R. Experimental aerosol Mycobacterium bovis model of infection in goats. Tuberculosis (Edinb). 2013 Sep;93(5):558-64. doi: 10.1016/j.tube.2013.05.006. Epub 2013 Jul 10. PubMed PMID: 23850102.

Gonzalez-Juarrero M, Mima N, Trunck LA, Schweizer HP, Bowen RA, Dascher K, Mwangi W, Eckstein TM. Polar lipids of Burkholderia pseudomallei induce different host immune responses. PLoS One. 2013 Nov 18;8(11):e80368. doi: 10.1371/journal.pone.0080368. eCollection 2013. PubMed PMID: 24260378; PubMed Central PMCID: PMC3832426.

Grzegorzewicz AE, Jackson M. Subfractionation and analysis of the cell envelope (lipo)polysaccharides of Mycobacterium tuberculosis. Methods Mol Biol. 2013;966:309-24. doi: 10.1007/978-1-62703-245-2_19. PubMed PMID: 23299743; PubMed Central PMCID: PMC4041545.

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Miller M, Buss P, Joubert J, Mathebula N, Kruger M, Martin L, Hofmeyr M, Olea-Popelka F. Use of butorphanol during immobilization of free-ranging white rhinoceros (Ceratotherium simum). J Zoo Wildl Med. 2013 Mar;44(1):55-61. PubMed PMID: 23505703.

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Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Fang S, McDonald  MA, Pohl J, Birkness K, Chamcha V, Ramirez MV, Plikaytis BB, Posey JE, Amara RR,  Sable SB. O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection. PLoS Pathog. 2013;9(10):e1003705. doi: 10.1371/journal.ppat.1003705.  Epub 2013 Oct 10. PubMed PMID: 24130497; PubMed Central PMCID: PMC3795050.

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Ramirez MV, Dawson CC, Crew R, England K, Slayden RA. MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. BMC Microbiol. 2013 Oct 31;13:240. doi: 10.1186/1471-2180-13-240. PubMed PMID: 24172039; PubMed Central PMCID: PMC3834876.

Rayner EL, Pearson GR, Hall GA, Basaraba RJ, Gleeson F, McIntyre A, Clark S,  Williams A, Dennis MJ, Sharpe SA. Early lesions following aerosol infection of rhesus macaques (Macaca mulatta) with Mycobacterium tuberculosis strain H37RV. J  Comp Pathol. 2013 Nov;149(4):475-85. doi: 10.1016/j.jcpa.2013.05.005. Epub 2013 Jul 21. PubMed PMID: 23880551.

Safi H, Lingaraju S, Amin A, Kim S, Jones M, Holmes M, McNeil M, Peterson SN, Chatterjee D, Fleischmann R, Alland D. Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes. Nat Genet. 2013 Oct;45(10):1190-7. doi: 10.1038/ng.2743. Epub 2013 Sep 1. PubMed PMID: 23995136.

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Shanley CA, Streicher EM, Warren RM, Victor TC, Orme IM. Characterization of  W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape. Vaccine.  2013 Dec 5;31(50):5934-9. doi: 10.1016/j.vaccine.2013.10.044. Epub 2013 Oct 19. PubMed PMID: 24144471; PubMed Central PMCID: PMC3886241.

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Souza C, Davis WC, Eckstein TM, Sreevatsan S, Weiss DJ. Mannosylated lipoarabinomannans from Mycobacterium avium subsp. paratuberculosis alters the inflammatory response by bovine macrophages and suppresses killing of Mycobacterium avium subsp. avium organisms. PLoS One. 2013 Sep 30;8(9):e75924. doi: 10.1371/journal.pone.0075924. eCollection 2013. PubMed PMID: 24098744; PubMed Central PMCID: PMC3786972.

Speer A, Shrestha TB, Bossmann SH, Basaraba RJ, Harber GJ, Michalek SM, Niederweis M, Kutsch O, Wolschendorf F. Copper-boosting compounds: a novel concept for antimycobacterial drug discovery. Antimicrob Agents Chemother. 2013 Feb;57(2):1089-91. doi: 10.1128/AAC.01781-12. Epub 2012 Dec 17. PubMed PMID: 23254420; PubMed Central PMCID: PMC3553712.

Sun J, Singh V, Lau A, Stokes RW, Obregón-Henao A, Orme IM, Wong D, Av-Gay Y, Hmama Z. Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. PLoS Pathog. 2013;9(7):e1003499. doi: 10.1371/journal.ppat.1003499. Epub 2013 Jul 18. PubMed PMID: 23874203; PubMed Central PMCID: PMC3715411.

Thirunavukkarasu S, Plain KM, Eckstein TM, de Silva K, Whittington RJ. Cellular and humoral immunogenicity of Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigens. Res Vet Sci. 2013 Aug;95(1):123-9. doi: 10.1016/j.rvsc.2013.03.002. Epub 2013 Mar 27. PubMed PMID:  23540605.

Weng X, Xing Y, Liu J, Wang Y, Ning Y, Li M, Wu W, Zhang L, Li W, Heiden JV,  Vissa V. Molecular, ethno-spatial epidemiology of leprosy in China: novel insights for tracing leprosy in endemic and non endemic provinces. Infect Genet Evol. 2013 Mar;14:361-8. doi: 10.1016/j.meegid.2012.12.009. Epub 2013 Jan 4. PubMed PMID: 23291419; PubMed Central PMCID: PMC3668695.

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Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel  Y, Zhang P, Ojha AK. Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. J Biol Chem. 2013 Jan 4;288(1):382-92. doi: 10.1074/jbc.M112.419754. Epub 2012 Nov 15. PubMed PMID: 23155047; PubMed Central PMCID: PMC3537035.

Adams MK, Goodrich LR, Rao S, Olea-Popelka F, Phillips N, Kisiday JD, McIlwraith CW. Equine bone marrow-derived mesenchymal stromal cells (BMDMSCs) from the ilium and sternum: are there differences? Equine Vet J. 2013 May;45(3):372-5. doi: 10.1111/j.2042-3306.2012.00646.x. Epub 2012 Sep 26. PubMed PMID: 23009322; PubMed Central PMCID: PMC3581704.

Alphey MS, Pirrie L, Torrie LS, Boulkeroua WA, Gardiner M, Sarkar A, Maringer  M, Oehlmann W, Brenk R, Scherman MS, McNeil M, Rejzek M, Field RA, Singh M, Gray D, Westwood NJ, Naismith JH. Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. ACS Chem Biol. 2013 Feb 15;8(2):387-96. doi: 10.1021/cb300426u. Epub 2012 Nov 28. PubMed PMID: 23138692.

Berrian AM, O’Keeffe J, White PW, Norris J, Litt J, More SJ, Olea-Popelka FJ.  Risk of bovine tuberculosis for cattle sold out from herds during 2005 in Ireland. Vet Rec. 2012 Jun 16;170(24):620. doi: 10.1136/vr.100674. Epub 2012 May 29. PubMed PMID: 22645153.

Bhamidi S, Shi L, Chatterjee D, Belisle JT, Crick DC, McNeil MR. A bioanalytical method to determine the cell wall composition of Mycobacterium tuberculosis grown in vivo. Anal Biochem. 2012 Feb 1;421(1):240-9. doi: 10.1016/j.ab.2011.10.046. Epub 2011 Nov 4. PubMed PMID: 22107887.

Bisson GP, Mehaffy C, Broeckling C, Prenni J, Rifat D, Lun DS, Burgos M, Weissman D, Karakousis PC, Dobos K. Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis. J Bacteriol. 2012 Dec;194(23):6441-52. doi: 10.1128/JB.01013-12. Epub 2012 Sep 21. PubMed PMID: 23002228; PubMed Central PMCID: PMC3497527.

Bolling BG, Olea-Popelka FJ, Eisen L, Moore CG, Blair CD. Transmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laboratory colony and effects of co-infection on vector competence for West Nile virus. Virology. 2012 Jun 5;427(2):90-7. doi: 10.1016/j.virol.2012.02.016. Epub 2012 Mar 16. PubMed PMID: 22425062; PubMed Central PMCID: PMC3329802.

Brennan MJ, Clagett B, Fitzgerald H, Chen V, Williams A, Izzo AA, Barker LF. Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis. Vaccine. 2012 Apr 16;30(18):2811-23. doi: 10.1016/j.vaccine.2012.02.036. Epub 2012 Mar 3. Review. PubMed PMID: 22387630; PubMed Central PMCID: PMC3335191.

Brennan PJ. A new TB vaccine blueprint. Tuberculosis (Edinb). 2012 Mar;92 Suppl 1:S1. doi: 10.1016/S1472-9792(12)00049-2. PubMed PMID: 22441151.

Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76. doi: 10.1073/pnas.1210500109. Epub 2012 Oct 23. PubMed PMID: 23093667; PubMed Central PMCID: PMC3503152.

Chavadi SS, Onwueme KC, Edupuganti UR, Jerome J, Chatterjee D, Soll CE, Quadri LE. The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipids. Microbiology. 2012 May;158(Pt 5):1379-87. doi: 10.1099/mic.0.057869-0. Epub 2012 Feb 23. PubMed PMID: 22361940; PubMed Central PMCID: PMC3542824.

Cho YS, Dobos KM, Prenni J, Yang H, Hess A, Rosenkrands I, Andersen P, Ryoo SW, Bai GH, Brennan MJ, Izzo A, Bielefeldt-Ohmann H, Belisle JT. Deciphering the proteome of the in vivo diagnostic reagent “purified protein derivative” from Mycobacterium tuberculosis. Proteomics. 2012 Apr;12(7):979-91. doi: 10.1002/pmic.201100544. PubMed PMID: 22522804; PubMed Central PMCID: PMC3756804.

Davidson RM, Hasan NA, de Moura VC, Duarte RS, Jackson M, Strong M. Phylogenomics of Brazilian epidemic isolates of Mycobacterium abscessus subsp. bolletii reveals relationships of global outbreak strains. Infect Genet Evol. 2013 Dec;20:292-7. doi: 10.1016/j.meegid.2013.09.012. Epub 2013 Sep 18. PubMed PMID: 24055961; PubMed Central PMCID: PMC3853122.

De Groote MA, Gruppo V, Woolhiser LK, Orme IM, Gilliland JC, Lenaerts AJ. Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Feb;56(2):731-8. doi: 10.1128/AAC.05701-11. Epub 2011 Dec 5. PubMed PMID: 22143517; PubMed Central PMCID: PMC3264252.

Debnath J, Siricilla S, Wan B, Crick DC, Lenaerts AJ, Franzblau SG, Kurosu M. Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis. J Med Chem. 2012 Apr 26;55(8):3739-55. doi: 10.1021/jm201608g. Epub 2012 Apr 6. PubMed PMID: 22449052; PubMed Central PMCID: PMC3375340.

Dennis P, Ellis S, Mellen J, Lee P, Olea-Popelka F, Petric A, Ryder O. IOD in rhinos–epidemiology group report: report from the Epidemiology Working Group of  the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). J Zoo Wildl Med. 2012 Sep;43(3 Suppl):S114-6. PubMed PMID: 23156714.

Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS,  Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis. 2012 Jan 1;205(1):152-61. doi: 10.1093/infdis/jir621. Epub 2011 Oct 11. PubMed PMID: 21990421; PubMed Central PMCID: PMC3242739.

Driver ER, Ryan GJ, Hoff DR, Irwin SM, Basaraba RJ, Kramnik I, Lenaerts AJ. Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice  for testing of drugs against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Jun;56(6):3181-95. doi: 10.1128/AAC.00217-12. Epub 2012 Apr 2. PubMed PMID: 22470120; PubMed Central PMCID: PMC3370740.

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Fisher CW, Fiorello A, Shaffer D, Jackson M, McDonnell GE. Aldehyde-resistant mycobacteria bacteria associated with the use of endoscope reprocessing systems.  Am J Infect Control. 2012 Nov;40(9):880-2. doi: 10.1016/j.ajic.2011.11.004. Epub  2012 Feb 10. PubMed PMID: 22325730; PubMed Central PMCID: PMC3523318.

Fontes AN, Gomes HM, Araujo MI, Albuquerque EC, Baptista IM, Moura MM, Rezende DS, Pessolani MC, Lara FA, Pontes MA, Gonçalves Hde S, Lucena-Silva N, Sarno EN, Vissa VD, Brennan PJ, Suffys PN. Genotyping of Mycobacterium leprae present on Ziehl-Neelsen-stained microscopic slides and in skin biopsy samples from leprosy patients in different geographic regions of Brazil. Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:143-9. PubMed PMID: 23283465.

Franzblau SG, DeGroote MA, Cho SH, Andries K, Nuermberger E, Orme IM, Mdluli  K, Angulo-Barturen I, Dick T, Dartois V, Lenaerts AJ. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.  Tuberculosis (Edinb). 2012 Nov;92(6):453-88. doi: 10.1016/j.tube.2012.07.003. Epub 2012 Aug 30. Review. PubMed PMID: 22940006.

Fávaro WJ, Nunes OS, Seiva FR, Nunes IS, Woolhiser LK, Durán N, Lenaerts AJ.  Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer. Infect Agent Cancer. 2012 Jun 18;7(1):14. doi: 10.1186/1750-9378-7-14. PubMed PMID: 22709446; PubMed Central PMCID: PMC3408364.

Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24;5(208):ra7. doi: 10.1126/scisignal.2002525. PubMed PMID: 22275220; PubMed Central PMCID: PMC3664666.

Geluk A, Bobosha K, van der Ploeg-van Schip JJ, Spencer JS, Banu S, Martins MV, Cho SN, Franken KL, Kim HJ, Bekele Y, Uddin MK, Hadi SA, Aseffa A, Pessolani MC, Pereira GM, Dockrell HM, Ottenhoff TH. New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy. J Immunol. 2012 May 15;188(10):4782-91. doi: 10.4049/jimmunol.1103452. Epub 2012 Apr 13. PubMed PMID: 22504648; PubMed Central PMCID: PMC3345093.

Gonzalez-Juarrero M, Woolhiser LK, Brooks E, DeGroote MA, Lenaerts AJ. Mouse  model for efficacy testing of antituberculosis agents via intrapulmonary delivery. Antimicrob Agents Chemother. 2012 Jul;56(7):3957-9. doi: 10.1128/AAC.00464-12. Epub 2012 Apr 30. PubMed PMID: 22547626; PubMed Central PMCID: PMC3393411.

Gonzalez-Juarrero M. Immunity to TB and targets for immunotherapy. Immunotherapy. 2012 Feb;4(2):187-99. doi: 10.2217/imt.11.168. Review. PubMed PMID: 22339461.

Grant KR, Campbell TW, Silver TI, Olea-Popelka FJ. Validation of an ultrasound-guided technique to establish a liver-to-coelom ratio and a comparative analysis of the ratios among acclimated and recently wild-caught southern stingrays, Dasyatis americana. Zoo Biol. 2013 Jan-Feb;32(1):104-11. doi: 10.1002/zoo.21014. Epub 2012 May 15. PubMed PMID: 22588699.

Grover A, Troudt J, Arnett K, Izzo L, Lucas M, Strain K, McFarland C, Hall Y, McMurray D, Williams A, Dobos K, Izzo A. Assessment of vaccine testing at three laboratories using the guinea pig model of tuberculosis. Tuberculosis (Edinb). 2012 Jan;92(1):105-11. doi: 10.1016/j.tube.2011.09.003. Epub 2011 Oct 1. PubMed PMID: 21962569; PubMed Central PMCID: PMC3269498.

Grover A, Izzo AA. BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages. PLoS One. 2012;7(7):e40836. doi: 10.1371/journal.pone.0040836. Epub 2012 Jul 13. PubMed PMID: 22808273; PubMed Central PMCID: PMC3396635.

Grzegorzewicz AE, Korduláková J, Jones V, Born SE, Belardinelli JM, Vaquié A, Gundi VA, Madacki J, Slama N, Laval F, Vaubourgeix J, Crew RM, Gicquel B, Daffé M, Morbidoni HR, Brennan PJ, Quémard A, McNeil MR, Jackson M. A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone. J Biol Chem. 2012 Nov 9;287(46):38434-41. doi: 10.1074/jbc.M112.400994. Epub 2012 Sep 21. PubMed PMID: 23002234; PubMed Central PMCID: PMC3493888.

Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012 Feb 19;8(4):334-41. doi: 10.1038/nchembio.794. PubMed PMID: 22344175; PubMed Central  PMCID: PMC3307863.

Henao-Tamayo M, Obregón-Henao A, Ordway DJ, Shang S, Duncan CG, Orme IM. A mouse model of tuberculosis reinfection. Tuberculosis (Edinb). 2012 May;92(3):211-7. doi: 10.1016/j.tube.2012.02.008. Epub 2012 Mar 17. PubMed PMID:  22429719.

Henneveld K, Rosychuk RA, Olea-Popelka FJ, Hyatt DR, Zabel S. Corynebacterium spp. in dogs and cats with otitis externa and/or media: a retrospective study. J  Am Anim Hosp Assoc. 2012 Sep-Oct;48(5):320-6. doi: 10.5326/JAAHA-MS-5791. Epub 2012 Jul 27. PubMed PMID: 22843832.

Kato-Maeda M, Shanley CA, Ackart D, Jarlsberg LG, Shang S, Obregon-Henao A, Harton M, Basaraba RJ, Henao-Tamayo M, Barrozo JC, Rose J, Kawamura LM, Coscolla  M, Fofanov VY, Koshinsky H, Gagneux S, Hopewell PC, Ordway DJ, Orme IM. Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig. Clin Vaccine Immunol. 2012 Aug;19(8):1227-37. doi: 10.1128/CVI.00250 12. Epub 2012 Jun 20. PubMed PMID: 22718126; PubMed Central PMCID: PMC3416080.

Ketusing N, Reeves A, Portacci K, Yano T, Olea-Popelka F, Keefe T, Salman M.  Evaluation of strategies for the eradication of Pseudorabies virus (Aujeszky’s disease) in commercial swine farms in Chiang-Mai and Lampoon Provinces, Thailand, using a simulation disease spread model. Transbound Emerg Dis. 2014 Apr;61(2):169-76. doi: 10.1111/tbed.12017. Epub 2012 Oct 3. PubMed PMID: 23033968.

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Li W, Matsuoka M, Kai M, Thapa P, Khadge S, Hagge DA, Brennan PJ, Vissa V. Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types. J Clin Microbiol. 2012 Mar;50(3):742-53. doi: 10.1128/JCM.05183-11. Epub 2011 Dec 14. PubMed PMID: 22170923; PubMed Central PMCID: PMC3295127.

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Mahapatra S, Woolhiser LK, Lenaerts AJ, Johnson JL, Eisenach KD, Joloba ML, Boom WH, Belisle JT. A novel metabolite of antituberculosis therapy demonstrates  host activation of isoniazid and formation of the isoniazid-NAD+ adduct. Antimicrob Agents Chemother. 2012 Jan;56(1):28-35. doi: 10.1128/AAC.05486-11. Epub 2011 Oct 28. PubMed PMID: 22037847; PubMed Central PMCID: PMC3256082.

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Miller M, Olea-Popelka F. One Health in the shrinking world: experiences with tuberculosis at the human-livestock-wildlife interface. Comp Immunol Microbiol Infect Dis. 2013 May;36(3):263-8. doi: 10.1016/j.cimid.2012.07.005. Epub 2012 Aug 22. Review. PubMed PMID: 22921281.

Miller M, Olea-Popelka F, Joubert J, Mathebula N, Zimmerman D, Hausler G, Dreyer C, Hofmeyr M, Buss P. Serum iron and selected biochemical values in free-ranging black rhinoceros (Diceros bicornis) from South Africa. J Zoo Wildl Med. 2012 Sep;43(3 Suppl):S55-60. PubMed PMID: 23156706.

Miller M, Joubert J, Mathebula N, De Klerk-Lorist LM, Lyashchenko KP, Bengis  R, van Helden P, Hofmeyr M, Olea-Popelka F, Greenwald R, Esfandiari J, Buss P. Detection of antibodies to tuberculosis antigens in free ranging lions (Panthera leo) infected with Mycobacterium bovis in Kruger National Park, South Africa. J Zoo Wildl Med. 2012 Jun;43(2):317-23. PubMed PMID: 22779235.

Miller M, Jago M, Radcliffe R, VdB Morkel P, Olea-Popelka F, Sefton J, du Preez P, Taft A, Nydam D, Gleed RD. Capture-related hypoglycemia and recovery in free-ranging black rhinoceroses (Diceros bicornis bicornis). J Wildl Dis. 2012 Jul;48(3):840-2. PubMed PMID: 22740562.

Molins CR, Delorey MJ, Young JW, Yockey BM, Belisle JT, Schriefer ME, Petersen JM. Use of temperature for standardizing the progression of Francisella  tularensis in mice. PLoS One. 2012;7(9):e45310. doi: 10.1371/journal.pone.0045310. Epub 2012 Sep 24. PubMed PMID: 23028924; PubMed Central PMCID: PMC3454384.

Muwonge A, Johansen TB, Vigdis E, Godfroid J, Olea-Popelka F, Biffa D, Skjerve E, Djønne B. Mycobacterium bovis infections in slaughter pigs in Mubende  district, Uganda: a public health concern. BMC Vet Res. 2012 Sep 21;8:168. doi: 10.1186/1746-6148-8-168. PubMed PMID: 22999303; PubMed Central PMCID: PMC3526550.

Obregón-Henao A, Duque-Correa MA, Rojas M, García LF, Brennan PJ, Ortiz BL, Belisle JT. Stable extracellular RNA fragments of Mycobacterium tuberculosis induce early apoptosis in human monocytes via a caspase-8 dependent mechanism. PLoS One. 2012;7(1):e29970. doi: 10.1371/journal.pone.0029970. Epub 2012 Jan 9. PubMed PMID: 22253841; PubMed Central PMCID: PMC3253812.

Obregón-Henao A, Crystal A. Shanley, Shaobin Shang, Megan L. Caraway,  Randall J. Basaraba, Colleen G. Duncan, Diane J. Ordway, and Ian M. Orme. Cortisone-forced reactivation of weakly acid fast positive Mycobacterium tuberculosis in guinea pigs previously treated with chemotherapy.  Mycobacterial Diseases. 2012. 2:3.

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Parlane NA, Compton BJ, Hayman CM, Painter GF, Basaraba RJ, Heiser A, Buddle BM. Phosphatidylinositol di-mannoside and derivates modulate the immune response  to and efficacy of a tuberculosis protein vaccine against Mycobacterium bovis infection. Vaccine. 2012 Jan 11;30(3):580-8. doi: 10.1016/j.vaccine.2011.11.055.  Epub 2011 Nov 24. PubMed PMID: 22120192.

Parlane NA, Grage K, Mifune J, Basaraba RJ, Wedlock DN, Rehm BH, Buddle BM. Vaccines displaying mycobacterial proteins on biopolyester beads stimulate cellular immunity and induce protection against tuberculosis. Clin Vaccine Immunol. 2012 Jan;19(1):37-44. doi: 10.1128/CVI.05505-11. Epub 2011 Nov 9. PubMed PMID: 22072720; PubMed Central PMCID: PMC3255957.

Peng W, Zou L, Bhamidi S, McNeil MR, Lowary TL. The galactosamine residue in  mycobacterial arabinogalactan is α-linked. J Org Chem. 2012 Nov 2;77(21):9826-32. doi: 10.1021/jo301393s. Epub 2012 Oct 17. PubMed PMID: 23043372.

Péterfia B, Füle T, Baghy K, Szabadkai K, Fullár A, Dobos K, Zong F, Dobra K, Hollósi P,  Jeney A, Paku S, Kovalszky I.  Syndecan-1 enhances proliferation, migration and metastasis  of HT-1080 cells in cooperation with syndecan-2.  PLoS One. 2012; 7(6):e39474. doi: 10.1371/journal.pone.0039474. Epub 2012 Jun 26.

Phetsuksiri B, Srisungngam S, Rudeeaneksin J, Bunchoo S, Lukebua A, Wongtrungkapun R, Paitoon S, Sakamuri RM, Brennan PJ, Vissa V. SNP genotypes of Mycobacterium leprae isolates in Thailand and their combination with rpoT and TTC genotyping for analysis of leprosy distribution and transmission. Jpn J Infect Dis. 2012;65(1):52-6. PubMed PMID: 22274158.

Podell BK, Ackart DF, Kirk NM, Eck SP, Bell C, Basaraba RJ. Non-diabetic hyperglycemia exacerbates disease severity in Mycobacterium tuberculosis infected guinea pigs. PLoS One. 2012;7(10):e46824. doi: 10.1371/journal.pone.0046824. Epub 2012 Oct 4. PubMed PMID: 23056469; PubMed Central PMCID: PMC3464230.

Rakesh, Bruhn D, Madhura DB, Maddox M, Lee RB, Trivedi A, Yang L, Scherman MS, Gilliland JC, Gruppo V, McNeil MR, Lenaerts AJ, Meibohm B, Lee RE. Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties.  Bioorg Med Chem. 2012 Oct 15;20(20):6063-72. Doi 10.1016/j.bmc.2012.08.023. Epub 2012 Aug 28. PubMed PMID: 22995771; PubMed Central PMCID: PMC3582038.

Reisfeld B, Metzler CP, Lyons MA, Mayeno AN, Brooks EJ, Degroote MA. A physiologically based pharmacokinetic model for capreomycin. Antimicrob Agents Chemother. 2012 Feb;56(2):926-34. doi: 10.1128/AAC.05180-11. Epub 2011 Dec 5. PubMed PMID: 22143528; PubMed Central PMCID: PMC3264208.

Sarkar S, Tang XL, Das D, Spencer JS, Lowary TL, Suresh MR. A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings. PLoS One 2012;7(2):e32340. doi: 10.1371/journal.pone.0032340. Epub 2012 Feb 21. PubMed PMID: 22363820; PubMed Central PMCID: PMC3283739.

Scherman MS, North EJ, Jones V, Hess TN, Grzegorzewicz AE, Kasagami T, Kim IH, Merzlikin O, Lenaerts AJ, Lee RE, Jackson M, Morisseau C, McNeil MR. Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability Bioorg Med Chem. 2012 May 15;20(10):3255-62. doi: 10.1016/j.bmc.2012.03.058. Epub 2012 Mar 31 PubMed PMID: 22522007; PubMed Central PMCID: PMC3345085.

Shang S, Shanley CA, Caraway ML, Orme EA, Henao-Tamayo M, Hascall-Dove L, Ackart D, Orme IM, Ordway DJ, Basaraba RJ. Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis. Vaccine. 2012 Feb 21;30(9):1572-82. doi: 10.1016/j.vaccine.2011.12.114. Epub 2012 Jan 11. PubMed PMID: 22244979; PubMed Central PMCID: PMC3286658.

Shikani AH, Kourelis K, Rohayem Z, Basaraba RJ, Leid JG. Topical gel therapy for sinonasal polyposis in Samter’s triad: preliminary report. Ann Otol Rhinol Laryngol. 2012 Nov;121(11):719-24. PubMed PMID: 23193904.

Slayden RA, Jackson M, Zucker J, Ramirez MV, Dawson CC, Crew R, Sampson NS, Thomas ST, Jamshidi N, Sisk P, Caspi R, Crick DC, McNeil MR, Pavelka MS, Niederweis M, Siroy A, Dona V, McFadden J, Boshoff H, Lew JM. Updating and curating metabolic pathways of TB. Tuberculosis (Edinb). 2013 Jan;93(1):47-59. doi: 10.1016/j.tube.2012.11.001. Epub 2013 Feb 1. Review. PubMed PMID: 23375378;  PubMed Central PMCID: PMC4121119.

Somashekar BS, Amin AG, Tripathi P, MacKinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, Orme IM, Ordway DJ, Chatterjee D. Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis. J Proteome Res. 2012 Oct 5;11(10):4873-84. doi: 10.1021/pr300345x. Epub 2012 Aug 30. PubMed  PMID: 22873951.

Speer A, Shrestha TB, Bossmann SH, Basaraba RJ, Harber GJ, Michalek SM, Niederweis M, Kutsch O, Wolschendorf F. Copper-boosting compounds: a novel concept for antimycobacterial drug discovery. Antimicrob Agents Chemother. 2013 Feb;57(2):1089-91. doi: 10.1128/AAC.01781-12. Epub 2012 Dec 17. PubMed PMID: 23254420; PubMed Central PMCID: PMC3553712.

Spencer JS, Duthie MS, Geluk A, Balagon MF, Kim HJ, Wheat WH, Chatterjee D, Jackson M, Li W, Kurihara JN, Maghanoy A, Mallari I, Saunderson P, Brennan PJ, Dockrell HM. Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy. Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:79-89. PubMed PMID: 23283458.

Sutherland MD, Goodyear AW, Troyer RM, Chandler JC, Dow SW, Belisle JT. Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia. Vaccine. 2012 Jul 13;30(33):4977-82. doi: 10.1016/j.vaccine.2012.05.037. Epub 2012 May 28. PubMed PMID: 22652404; PubMed Central PMCID: PMC3576924.

Tatham E, Sundaram Chavadi S, Mohandas P, Edupuganti UR, Angala SK, Chatterjee D, Quadri LE. Production of mycobacterial cell wall glycopeptidolipids requires a member of the MbtH-like protein family. BMC Microbiol. 2012 Jun 22;12:118. doi: 10.1186/1471-2180-12-118. PubMed PMID: 22726990; PubMed Central PMCID: PMC3537567.

Taylor JL, Wieczorek A, Keyser AR, Grover A, Flinkstrom R, Karls RK, Bielefeldt-Ohmann H, Dobos KM, Izzo AA. HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule. Immunol Cell Biol. 2012 Nov;90(10):945-54. doi: 10.1038/icb.2012.34. Epub 2012 Jul 17. PubMed  PMID: 22801575; PubMed Central PMCID: PMC3511932.

Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 2012 Aug;22(8):1118-27. doi: 10.1093/glycob/cws078. Epub 2012 Apr 25. PubMed PMID: 22534567; PubMed Central PMCID: PMC3382347.

Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME. Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria. J Biol Chem. 2012 Jul 13;287(29):24649-61. doi: 10.1074/jbc.M112.368191. Epub 2012 May 25. PubMed PMID: 22637481; PubMed Central  PMCID: PMC3397893.

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Walter ND, Strong M, Belknap R, Ordway DJ, Daley CL, Chan ED. Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis. Respirology. 2012 Jul;17(5):772-91. doi: 10.1111/j.1440-1843.2012.02176.x. Review. PubMed PMID: 22458269.

Yang H, Kruh-Garcia NA, Dobos KM. Purified protein derivatives of tuberculin–past, present, and future. FEMS Immunol Med Microbiol. 2012 Dec;66(3):273-80. doi: 10.1111/j.1574-695X.2012.01002.x. Epub 2012 Aug 1. Review. PubMed PMID: 22762692; PubMed Central PMCID: PMC3491170.

Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel Y, Zhang P, Ojha AK. Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. J Biol Chem. 2013 Jan 4;288(1):382-92. doi: 10.1074/jbc.M112.419754. Epub 2012 Nov 15. PubMed PMID: 23155047; PubMed Central PMCID: PMC3537035.

Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC. Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161. Open AIDS J. 2011; 5:86-95. Epub 2011 Oct 19.

Palanisamy GS, Kirk NM, Ackart DF, Shanley CA, Orme IM, Basaraba RJ. Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis. PLoS One. 2011; 6(10):e26254. Epub 2011 Oct 18.

Kenyon CL, Basaraba RJ, Bohn AA. Influence of endurance exercise on serum concentrations of iron and acute phase proteins in racing sled dogs. J Am Vet Med Assoc. 2011 Nov 1; 239(9):1201-10.

Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis. 2012 Jan 1; 205(1):152-61. Epub 2011 Oct 11.

Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA. Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest. 2011 Sep; 121(9):3554-63. doi: 10.1172/JCI46095. Epub 2011 Aug 1.

Ordway DJ, Shang S, Henao-Tamayo M, Obregon-Henao A, Nold L, Caraway M, Shanley CA, Basaraba RJ, Duncan CG, Orme IM. Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells. Clin Vaccine Immunol. 2011 Sep; 18(9):1527-35. Epub 2011 Jul 27.

Shang S, Harton M, Tamayo MH, Shanley C, Palanisamy GS, Caraway M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ. Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. Tuberculosis (Edinb). 2011 Sep; 91(5):378-85. Epub 2011 Jul 6.

Somashekar BS, Amin AG, Rithner CD, Troudt J, Basaraba R, Izzo A, Crick DC, Chatterjee D. Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies. J Proteome Res. 2011 Sep 2; 10(9):4186-95. Epub 2011 Jul 26.

Obregón-Henao A, Shanley C, Bianco MV, Cataldi AA, Basaraba RJ, Orme IM, Bigi F. Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis. Vaccine. 2011 Jun 10; 29(26):4302-7. Epub 2011 Apr 22.

Dharmadhikari AS, Basaraba RJ, Van Der Walt ML, Weyer K, Mphahlele M, Venter K, Jensen PA, First MW, Parsons S, McMurray DN, Orme IM, Nardell EA. Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis. Tuberculosis (Edinb). 2011 Jul; 91(4):329-38. Epub 2011 Apr 7.

Hoff DR, Ryan GJ, Driver ER, Ssemakulu CC, De Groote MA, Basaraba RJ, Lenaerts AJ. Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment. PLoS One. 2011 Mar 21; 6(3):e17550.

Shang S, Ordway D, Henao-Tamayo M, Bai X, Oberley-Deegan R, Shanley C, Orme IM, Case S, Minor M, Ackart D, Hascall-Dove L, Ovrutsky AR, Kandasamy P, Voelker DR, Lambert C, Freed BM, Iseman MD, Basaraba RJ, Chan ED. Cigarette smoke increases susceptibility to tuberculosis–evidence from in vivo and in vitro models.  J Infect Dis. 2011 May 1;203(9):1240-8. Epub 2011 Feb 28.

Wolschendorf F, Ackart D, Shrestha TB, Hascall-Dove L, Nolan S, Lamichhane G, Wang Y, Bossmann SH, Basaraba RJ, Niederweis M. Copper resistance is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1621-6. Epub 2011 Jan 4.

Nahid P, Saukkonen J, Mac Kenzie WR, Johnson JL, Phillips PP, Andersen J, Bliven-Sizemore E, Belisle JT, Boom WH, Luetkemeyer A, Campbell TB, Eisenach KD, Hafner R, Lennox JL, Makhene M, Swindells S, Villarino ME, Weiner M, Benson C, Burman W; National Institutes of Health; Centers for Disease Control and Prevention. CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap. Am J Respir Crit Care Med. 2011 Oct 15; 184(8):972-9. doi: 10.1164/rccm.201105-0827WS.

Bhamidi S, Scherman MS, Jones V, Crick DC, Belisle JT, Brennan PJ, McNeil MR. Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis. J Biol Chem. 2011 Jul 1; 286(26):23168-77. Epub 2011 May 9.

Chandler JC, Molins CR, Petersen JM, Belisle JT. Differential chitinase activity and production within Francisella species, subspecies, and subpopulations. J Bacteriol. 2011 Jul; 193(13):3265-75. Epub 2011 Apr 29.

Sartain MJ, Dick DL, Rithner CD, Crick DC, Belisle JT. Lipidomic analyses of Mycobacterium tuberculosis based on accurate mass measurements and the novel “Mtb LipidDB”. J Lipid Res. 2011 May; 52(5):861-72. Epub 2011 Feb 1.

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Lobato J, Costa MP, Reis Ede M, Gonçalves MA, Spencer JS, Brennan PJ, Goulart LR, Goulart IM. Comparison of three immunological tests for leprosy diagnosis and detection of subclinical infection. Lepr Rev. 2011 Dec; 82(4):389-401.

Spencer JS, Brennan PJ. The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy. Lepr Rev. 2011 Dec; 82(4):344-57.

Brennan PJ. Future for laboratory based research for leprosy. Lepr Rev. 2011 Dec;82(4):330-3.

Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB. Invariant natural killer T cells recognize lipid self-antigen induced by microbial danger signals. Nat Immunol. 2011 Oct 30;12(12):1202-11. doi: 10.1038/ni.2143.

Al-Mubarak R, Vander Heiden J, Broeckling CD, Balagon M, Brennan PJ, Vissa VD. Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1303. Epub 2011 Sep 6.

Li W, Sakamuri RM, Lyons DE, Orcullo FM, Shinde V, Dela Pena EL, Maghanoy AA, Mallari IB, Tan EV, Nath I, Brennan PJ, Balagon M, Vissa V. Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches. Antimicrob Agents Chemother. 2011 Nov; 55(11):5384-7. Epub 2011 Aug 22.

Stavri H, Ulea I, Radu DL, Branaru MG, Moldovan O, Bogdan MA, Tudose C, Raileanu M, Duiculescu D, Ene L, Olar V, Ionita C, Popa GL, Popa MI, Brennan PJ. Serodiagnosis of environmental mycobacterial infections. J Microbiol Methods. 2011 Sep; 86(3):283-90. Epub 2011 May 20.

Spencer JS, Kim HJ, Wheat WH, Chatterjee D, Balagon MV, Cellona RV, Tan EV, Gelber R, Saunderson P, Duthie MS, Reece ST, Burman W, Belknap R, Mac Kenzie WR, Geluk A, Oskam L, Dockrell HM, Brennan PJ; IDEAL Consortium. Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy. Clin Vaccine Immunol. 2011 Feb; 18(2):260-7. Epub 2010 Dec 22.

Zhang J, Angala SK, Pramanik PK, Li K, Crick DC, Liav A, Jozwiak A, Swiezewska E, Jackson M, Chatterjee D. Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors. ACS Chem Biol. 2011 Aug 19; 6(8):819-28. doi: 10.1021/cb200091m. Epub 2011 May 26.

Dhiman RK, Dinadayala P, Ryan GJ, Lenaerts AJ, Schenkel AR, Crick DC.  Lipoarabinomannan localization and abundance during growth of Mycobacterium smegmatis.  J Bacteriol. 2011 Oct; 193(20):5802-9. doi: 10.1128/JB.05299-11. Epub 2011 Aug 12.

Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y.  Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.  J Med Chem. 2011 Jul 14; 54(13):4721-34. Epub 2011 Jun 2.

Magden ER, Weiner CM, Gilliland JC, DeGroote MA, Lenaerts AJ, Kendall LV.  Torticollis in mice intravenously infected with Mycobacterium tuberculosis.  J Am Assoc Lab Anim Sci. 2011 Mar; 50(2):244-7.

Yang H, Troudt J, Grover A, Arnett K, Lucas M, Cho YS, Bielefeldt-Ohmann H, Taylor J, Izzo A, Dobos KM.  Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.  Infect Immun. 2011 Feb; 79(2):716-23. doi: 10.1128/IAI.00486-10. Epub 2010 Dec 6.

Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL. Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp. 2011 May 2; (51). pii: 2702. doi: 10.3791/2702PMID:21587154  [PubMed – indexed for MEDLINE]

Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M.  Local pulmonary immunotherapy with siRNA targeting TGFß1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. Tuberculosis (Edinb). 2011 Jan; 91(1):98-106. Epub 2010 Dec 31.PMID:21195670 [PubMed – indexed for MEDLINE]

González-Juarrero M, O’Sullivan MP.  Optimization of inhaled therapies for tuberculosis: the role of macrophages and dendritic cells. Tuberculosis (Edinb). 2011 Jan; 91(1):86-92. Review.PMID:20888298 [PubMed – indexed for MEDLINE]

Gonzalez–Juarrero, M. Immunity to tuberculosis and targets for immunotherapy.  Review in Immunotherapy. Editorial Future Medicine. In press

Keyser, A. Troudt, J.M., Taylor, J.L., and Izzo A.A. (2011) BCG sub-strains induce variable protection against virulent pulmonary Mycobacterium tuberculosis infection, with the capacity to drive Th2 immunity. Vaccine 29:9308-0315

Aagaard C., T. Hoang, J. Dietrich, Cardona P.–J., Izzo A., Dolganov G., Schoolnik G.K., Cassidy J., Billeskov R., Andersen P. (2011) A multistage tuberculosis vaccine that confers efficient protection pre– and post–exposure.  Nature Medicine 17(2):189-94

Brown, J. R., E. J. North, J. G. Hurdle, C. Morisseau, J. S. Scarborough, D. Sun, J. Korduláková, M. S. Scherman, V. Jones, A. Grzegorzewicz, R. M. Crew, M. Jackson, M. R. McNeil, and R. E. Lee (2011). The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem 19(18): 5585-5595.

Shang, S., S. Gibbs, M. Henao-Tamayo, C. A. Shanley, G. McDonnell, R. S. Duarte, D. J. Ordway, and M. Jackson (2011). Increased virulence of an epidemic strain of Mycobacterium massiliense in mice. PLoS ONE 6(9): e24726.

Dianišková, P., J. Korduláková, H. Škovierová, D. Kaur, M. Jackson, P. J. Brennan, and K. Mikušová (2011). Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster. Gen. Physiol. Biophys. 30:239-250.

Santangelo, M. P., P. M. Gest, M. E. Guerin, M. Coinçon, H. Pham, G. Ryan, S. E. Puckett, J. S. Spencer, M. Gonzalez-Juarrero, R. Daher, A. J. Lenaerts, D. Schnappinger, M. Therisod, S. Ehrt, J. Sygusch, and M. Jackson (2011). Glycolytic and non-glycolytic functions of the fructose-1,6-bisphosphate aldolase of Mycobacterium tuberculosis, an essential enzyme produced by replicating and non-replicating bacilli. J. Biol. Chem. 286(46): 40219-40231.

Mathew B, Srivastava S, Ross LJ, Suling WJ, White EL, Woolhiser LK, Lenaerts AJ, Reynolds RC.  Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.  Bioorg Med Chem. 2011 Dec 1; 19(23):7120-8. doi: 10.1016/j.bmc.2011.09.062. Epub 2011 Oct 5.

De Groote MA, Gilliland JC, Wells CL, Brooks EJ, Woolhiser LK, Gruppo V, Peloquin CA, Orme IM, Lenaerts AJ.  Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis.  Antimicrob Agents Chemother. 2011 Mar; 55(3):1237-47. doi: 10.1128/AAC.00595-10. Epub 2010 Dec 6.

Shang S, Shanley CA, Caraway ML, Orme EA, Henao-Tamayo M, Hascall-Dove L, Ackart D, Lenaerts AJ, Basaraba RJ, Orme IM, Ordway DJ.  Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs.  Antimicrob Agents Chemother. 2011 Jan; 55(1):124-31. doi: 10.1128/AAC.00978-10. Epub 2010 Oct 11.

Wang, Y., T. N. Hess, V. Jones, J. Z. Zhou, M. R. McNeil, and J. A. McCammon. 2011. Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening. Bioorganic & Medicinal Chemistry Letters 21:7064-7067.

Xiyuan Baia, Kathryn Chmura, Alida R. Ovrutsky, Russell P. Bowlerb, Robert Scheinmane Rebecca E. Oberley-Deegan, Haiying Liuf, Shaobin Shang, Diane Ordway, Edward D. Chan, M. tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription. Tuberculosis. 2011. 91:26-35.

Henao-Temayo M., Irwin S. M., Shang S., Ordway D. J., Orme I. M.  T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis.  Tuberculosis (Edinb).  2011.91.308-13.

Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med. 2011. doi: 10.1038/nm.

Ordway DJ, Orme IM.  Animal models of mycobacteria infection.  Curr Protoc Immunol. 2011 Aug;Chapter 19:Unit19.5. doi: 10.1002/0471142735.im1905s94.

McShane H, Jacobs WR, Fine PE, Reed SG, McMurray DN, Behr M, Williams A, Orme IM.  BCG: myths, realities, and the need for alternative vaccine strategies.  Tuberculosis (Edinb). 2012 May; 92(3):283-8. doi: 10.1016/j.tube.2011.12.003. Epub 2012 Feb 18.

Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr.  A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.  Nat Med. 2011 Sep 4; 17(10):1261-8. doi: 10.1038/nm.2420.

Ching LK, Mompoint F, Guderian JA, Picone A, Orme IM, Coler RN, Reed SG, Baldwin SL.  Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.  J Immunol Methods. 2011 Oct 28; 373(1-2):54-62. doi: 10.1016/j.jim.2011.07.021. Epub 2011 Aug 3.

Orme IM.  Development of new vaccines and drugs for TB: limitations and potential strategic errors.  Future Microbiol. 2011 Feb; 6(2):161-77. doi: 10.2217/fmb.10.168.

Li X, Liu N, Zhang H, Knudson SE, Li HJ, Lai CT, Simmerling C, Slayden RA, Tonge PJ.  CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.  ACS Med Chem Lett. 2011 Nov 10; 2(11):818-823.

England K, Crew R, Slayden RA.  Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response.  BMC Microbiol. 2011 Apr 19; 11:79. doi: 10.1186/1471-2180-11-79.

Liu N, Cummings JE, England K, Slayden RA, Tonge PJ.  Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.  J Antimicrob Chemother. 2011 Mar; 66(3):564-73. doi: 10.1093/jac/dkq509. Epub 2011 Jan 22.

Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR, Nunberg JH.  A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus.  J Biol Chem. 2011 Feb 25; 286(8):6192-200. doi: 10.1074/jbc.M110.196428. Epub 2010 Dec 15.

Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I.  Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.  J Med Chem. 2011 Jan 13; 54(1):374-81. doi: 10.1021/jm1012006. Epub 2010 Dec 2.

Kingry LC, Troyer RM, Marlenee NL, Bielefeldt-Ohmann H, Bowen RA, Schenkel AR, Dow SW, Slayden RA.  Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.  Microbes Infect. 2011 Mar; 13(3):261-75. doi: 10.1016/j.micinf.2010.10.022. Epub 2010 Nov 9.

Lahiri R, Randhawa B, Franken KL, Duthie MS, Spencer JS, Geluk A, Krahenbuhl JL.  Development of a mouse food pad model for detection of sub clinical leprosy.  Lepr Rev. 2011 Dec; 82(4):432-44.

Geluk A, Duthie MS, Spencer JS.  Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease.  Lepr Rev. 2011 Dec; 82(4):402-21.

Geluk A, van den Eeden SJ, Dijkman K, Wilson L, Kim HJ, Franken KL, Spencer JS, Pessolani MC, Pereira GM, Ottenhoff TH.  ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria.  J Immunol. 2011 Aug 1; 187(3):1393-402. doi: 10.4049/jimmunol.1100980. Epub 2011 Jun 24.

Duthie MS, Truman RW, Goto W, O’Donnell J, Hay MN, Spencer JS, Carter D, Reed SG.  Insight toward early diagnosis of leprosy through analysis of the developing antibody responses of Mycobacterium leprae-infected armadillos.  Clin Vaccine Immunol. 2011 Feb; 18(2):254-9. doi: 10.1128/CVI.00420-10. Epub 2010 Dec 22.

M. Breer, B. Christensen and J. L. Taylor. Models in Movies: Teaching Abstract Concepts in Concrete Models. Manuscript submitted to Journal of Microbiology and Biology Education and currently in the review process, December 2011.

Weng XM, Li K, Wen Y, Xing Y, Liu J, Hong BH, Li HY, Vissa V.  [Study on the factors influencing steady transmission of leprosy in Qiubei County, China].  Zhonghua Liu Xing Bing Xue Za Zhi. 2011 Jun; 32(6):559-64.

Jensen RW, Rivest J, Li W, Vissa V.  DNA fingerprinting of Mycobacterium leprae strains using variable number tandem repeat (VNTR) – fragment length analysis (FLA).  J Vis Exp. 2011 Jul 15; (53):e3104. doi: 10.3791/3104.

Weng X, Vander Heiden J, Xing Y, Liu J, Vissa V.  Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.  Infect Genet Evol. 2011 Mar; 11(2):363-74. doi: 10.1016/j.meegid.2010.11.014. Epub 2010 Dec 1.

Discovery of anti-TB agents that target the cell-division protein FtsZ.  Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I.  Future Med Chem. 2010 Aug;2(8):1305-23.

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.  Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ.  Bioorg Med Chem Lett. 2010 Nov 1;20(21):6306-9.

An optical waveguide array biosensor for serology – biomed 2010.  Yan R, Lynn NS, Kingry LC, Slayden RA, Dandy DS, Lear KL.  Biomed Sci Instrum. 2010;46:45-50.

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.  Ryan GJ, Hoff DR, Driver ER, Voskuil MI, Gonzalez-Juarrero M, Basaraba RJ, Crick DC, Spencer JS, Lenaerts AJ.  PLoS One. 2010 Jun 14;5(6):e11108.

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.  Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, Malkinson AM.  J Leukoc Biol. 2010 Jul;88(1):159-68.

Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo.  Kruh NA, Troudt J, Izzo A, Prenni J, Dobos KM.  PLoS One. 2010 Nov 11;5(11):e13938.

BCG vaccination in the cotton rat (Sigmodon hispidus) infected by the pulmonary route with virulent Mycobacterium tuberculosis.  McFarland CT, Ly L, Jeevan A, Yamamoto T, Weeks B, Izzo A, McMurray D.  Tuberculosis (Edinb). 2010 Jul;90(4):262-7.

Initiation of acquired immunity in the lungs of mice lacking lymph nodes after infection with aerosolized Mycobacterium tuberculosis.  Kashino SS, Vallerskog T, Martens G, Troudt J, Keyser A, Taylor J, Izzo A, Kornfeld H, Campos-Neto A.  Am J Pathol. 2010 Jan;176(1):198-204.

Reduced transcript stabilization restricts TNF-alpha expression in RAW264.7 macrophages infected with pathogenic mycobacteria: evidence for an involvement of lipomannan.  Basler T, Holtmann H, Abel J, Eckstein T, Baumer W, Valentin-Weigand P, Goethe R.  J Leukoc Biol. 2010 Jan;87(1):173-83.

A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence.  Alonso-Hearn M, Eckstein TM, Sommer S, Bermudez LE.  Innate Immun. 2010 Aug;16(4):235-47.

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.  Ioerger TR, Feng Y, Chen X, Dobos KM, Victor TC, Streicher EM, Warren RM, Gey van Pittius NC, Van Helden PD, Sacchettini JC.  BMC Genomics. 2010 Nov 26;11:670.

Proteomic definition of the cell wall of Mycobacterium tuberculosis.  Wolfe LM, Mahaffey SB, Kruh NA, Dobos KM.  J Proteome Res. 2010 Nov 5;9(11):5816-26.

Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages.  Giri PK, Kruh NA, Dobos KM, Schorey JS.  Proteomics. 2010 Sep;10(17):3190-202.

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.  Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR Jr, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC.  J Bacteriol. 2010 Jul;192(14):3645-53.

Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis.  Mehaffy C, Hess A, Prenni JE, Mathema B, Kreiswirth B, Dobos KM.  Proteomics. 2010 May;10(10):1966-84.

Development of a plate-based scintillation proximity assay for the mycobacterial AftB enzyme involved in cell wall arabinan biosynthesis.  Zhang J, Amin AG, Hölemann A, Seeberger PH, Chatterjee D.  Bioorg Med Chem. 2010 Oct 1;18(19):7121-31.

A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae.  Zhang J, Chatterjee D, Brennan PJ, Spencer JS, Liav A.  Bioorg Med Chem Lett. 2010 Jun 1;20(11):3250-3.

Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis.  Romero IC, Mehaffy C, Burchmore RJ, Dobos-Elder K, Brennan P, Walker J.  Tuberculosis (Edinb). 2010 Jan;90(1):25-30.

Comparative genomic and phylogeographic analysis of Mycobacterium leprae.  Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamesipour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, Macdonald M, Sapkota BR, Spencer JS, Thomas J, Harshman K, Singh P, Busso P, Gattiker A, Rougemont J, Brennan PJ, Cole ST.  Nat Genet. 2009 Dec;41(12):1282-9. Epub 2009 Nov 1. Erratum in: Nat Genet. 2010 Apr;42(4):361. Khamispour, Ali [corrected to Khamesipour, Ali].

Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis.  Peltier P, Beláňová M, Dianišková P, Zhou R, Zheng RB, Pearcey JA, Joe M, Brennan PJ, Nugier-Chauvin C, Ferrières V, Lowary TL, Daniellou R, Mikušová K.  Chem Biol. 2010 Dec 22;17(12):1356-66.

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.  Skovierová H, Larrouy-Maumus G, Pham H, Belanová M, Barilone N, Dasgupta A, Mikusová K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson M.  J Biol Chem. 2010 Dec 31;285(53):41348-55.

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria.  Guerin ME, Korduláková J, Alzari PM, Brennan PJ, Jackson M.  J Biol Chem. 2010 Oct 29;285(44):33577-83.

Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients.  Deenadayalan A, Heaslip D, Rajendiran AA, Velayudham BV, Frederick S, Yang HL, Dobos K, Belisle JT, Raja A.  Mol Cell Proteomics. 2010 Mar;9(3):538-49.

Establishment of an aerosol challenge model of tuberculosis in rhesus macaques and an evaluation of endpoints for vaccine testing.  Sharpe SA, McShane H, Dennis MJ, Basaraba RJ, Gleeson F, Hall G, McIntyre A, Gooch K, Clark S, Beveridge NE, Nuth E, White A, Marriott A, Dowall S, Hill AV, Williams A, Marsh PD.  Clin Vaccine Immunol. 2010 Aug;17(8):1170-82.

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis.  Ordway DJ, Shanley CA, Caraway ML, Orme EA, Bucy DS, Hascall-Dove L, Henao-Tamayo M, Harton MR, Shang S, Ackart D, Kraft SL, Lenaerts AJ, Basaraba RJ, Orme IM.  Antimicrob Agents Chemother. 2010 May;54(5):1820-33.

Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria. Jani C, Eoh H, Lee JJ, Hamasha K, Sahana MB, Han JS, Nyayapathy S, Lee JY, Suh JW, Lee SH, Rehse SJ, Crick DC, Kang CM. BMC Microbiol. 2010 Dec 29;10:327.

DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon. Honaker RW, Dhiman RK, Narayanasamy P, Crick DC, Voskuil MI. J Bacteriol. 2010 Dec;192(24):6447-55.

Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Narayanasamy P, Eoh H, Brennan PJ, Crick DC. Chem Biol. 2010 Feb 26;17(2):117-22.

The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs. Brown AC, Eberl M, Crick DC, Jomaa H, Parish T. J Bacteriol. 2010 May;192(9):2424-33.

The Achilles heel of BCG.  Orme IM.  Tuberculosis (Edinb). 2010 Nov;90(6):329-32.

Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis.  Henao-Tamayo MI, Ordway DJ, Irwin SM, Shang S, Shanley C, Orme IM.  Clin Vaccine Immunol. 2010 Apr;17(4):618-25.

Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease.  Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ.  Am J Respir Cell Mol Biol. 2010 Oct;43(4):387-93.

A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis.  Bertholet S, Ireton GC, Ordway DJ, Windish HP, Pine SO, Kahn M, Phan T, Orme IM, Vedvick TS, Baldwin SL, Coler RN, Reed SG.  Sci Transl Med. 2010 Oct 13;2(53):53ra74. doi: 10.1126/scitranslmed.3001094.

The combination of rifampin plus moxifloxacin is synergistic for suppression of resistance but antagonistic for cell kill of Mycobacterium tuberculosis as determined in a hollow-fiber infection model.  Drusano GL, Sgambati N, Eichas A, Brown DL, Kulawy R, Louie A.  MBio. 2010 Aug 10;1(3). doi:pii: e00139-10.

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring.  Termentzi A, Khouri I, Gaslonde T, Prado S, Saint-Joanis B, Bardou F, Amanatiadou EP, Vizirianakis IS, Kordulakova J, Jackson M, Brosch R, Janin YL, Daffé M, Tillequin F, Michel S.  Eur J Med Chem. 2010 Dec;45(12):5833-47.

Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.  Daher R, Coinçon M, Fonvielle M, Gest PM, Guerin ME, Jackson M, Sygusch J, Therisod M.  J Med Chem. 2010 Nov 11;53(21):7836-42.

An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages.  Dasgupta A, Sureka K, Mitra D, Saha B, Sanyal S, Das AK, Chakrabarti P, Jackson M, Gicquel B, Kundu M, Basu J.  PLoS One. 2010 Aug 17;5(8):e12225.

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis.  Geluk A, Spencer JS, Bobosha K, Pessolani MC, Pereira GM, Banu S, Honoré N, Reece ST, MacDonald M, Sapkota BR, Ranjit C, Franken KL, Zewdie M, Aseffa A, Hussain R, Stefani MM, Cho SN, Oskam L, Brennan PJ, Dockrell HM; IDEAL Consortium.  Clin Vaccine Immunol. 2009 Mar;16(3):352-9.

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.  Gonzalez-Juarrero M, Kingry LC, Ordway DJ, Henao-Tamayo M, Harton M, Basaraba RJ, Hanneman WH, Orme IM, Slayden RA.  Am J Respir Cell Mol Biol. 2009 Apr;40(4):398-409.

Localized immunosuppressive environment in the foreign body response to implanted biomaterials.  Higgins DM, Basaraba RJ, Hohnbaum AC, Lee EJ, Grainger DW, Gonzalez-Juarrero M.  Am J Pathol. 2009 Jul;175(1):161-70.

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.  Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Lee EJ, Orme IM, Gonzalez-Juarrero M.  Tuberculosis (Edinb). 2009 Mar;89(2):149-57.

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.  Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M.  Am J Respir Cell Mol Biol. 2009 Aug;41(2):136-45.

Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosis.  Grover A, Taylor J, Troudt J, Keyser A, Arnett K, Izzo L, Rholl D, Izzo A.  Infect Immun. 2009 Nov;77(11):4837-46.

Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose.  Aagaard C, Hoang TT, Izzo A, Billeskov R, Troudt J, Arnett K, Keyser A, Elvang T, Andersen P, Dietrich J.  PLoS One. 2009 Jun 16;4(6):e5930.

Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis.  Xing Z, McFarland CT, Sallenave JM, Izzo A, Wang J, McMurray DN.  PLoS One. 2009 Jun 10;4(6):e5856.

Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.  Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC.  Vaccine. 2009 Jul 16;27(33):4412-23.

Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection.  Drumm JE, Mi K, Bilder P, Sun M, Lim J, Bielefeldt-Ohmann H, Basaraba R, So M, Zhu G, Tufariello JM, Izzo AA, Orme IM, Almo SC, Leyh TS, Chan J.  PLoS Pathog. 2009 May;5(5):e1000460. Epub 2009 May 29. Erratum in: PLoS Pathog. 2009 Sep;5(9). doi: 10.1371/annotation/2b1a4b06-9558-448b-a8e8-5e2d407816a0.

A novel cell wall lipopeptide is important for biofilm formation and pathogenicity of Mycobacterium avium subspecies paratuberculosis.  Wu CW, Schmoller SK, Bannantine JP, Eckstein TM, Inamine JM, Livesey M, Albrecht R, Talaat AM.  Microb Pathog. 2009 Apr;46(4):222-30.

A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis.  Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E, Levillain F, Taylor ME, Drickamer K, Nigou J, Dobos KM, Puzo G, Vestweber D, Wild MK, Marcinko M, Sobieszczuk P, Stewart L, Lebus D, Gicquel B, Neyrolles O.  J Exp Med. 2009 Sep 28;206(10):2205-20.

The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.  Maloney E, Stankowska D, Zhang J, Fol M, Cheng QJ, Lun S, Bishai WR, Rajagopalan M, Chatterjee D, Madiraju MV.  PLoS Pathog. 2009 Jul;5(7):e1000534.

Lipoglycans of Mycobacterium tuberculosis: isolation, purification, and characterization.  Shi L, Torrelles JB, Chatterjee D.  Methods Mol Biol. 2009;465:23-45.

A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A.  Stalford SA, Fascione MA, Sasindran SJ, Chatterjee D, Dhandayuthapani S, Turnbull WB.  Chem Commun (Camb). 2009 Jan 7;(1):110-2.

Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.  Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, Schlesinger LS.  J Biol Chem. 2008 Nov 14;283(46):31417-28.

The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.  Eoh H, Brennan PJ, Crick DC.  Tuberculosis (Edinb). 2009 Jan;89(1):1-11.

Polymethylated polysaccharides from Mycobacterium species revisited.  Jackson M, Brennan PJ.  J Biol Chem. 2009 Jan 23;284(4):1949-53.

Approaches to developing new drugs against tuberculosis.  Brennan PJ.  Tuberculosis (Edinb). 2009 Sep;89(5):329-30. Epub 2009 Oct 12. No abstract available.

Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.  Kaur D, Guerin ME, Skovierová H, Brennan PJ, Jackson M.  Adv Appl Microbiol. 2009;69:23-78.

Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.  Scherman H, Kaur D, Pham H, Skovierová H, Jackson M, Brennan PJ.  J Bacteriol. 2009 Nov;191(21):6769-72.

AftD, a novel essential arabinofuranosyltransferase from mycobacteria.  Skovierová H, Larrouy-Maumus G, Zhang J, Kaur D, Barilone N, Korduláková J, Gilleron M, Guadagnini S, Belanová M, Prevost MC, Gicquel B, Puzo G, Chatterjee D, Brennan PJ, Nigou J, Jackson M.  Glycobiology. 2009 Nov;19(11):1235-47.

New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB’ is an essential enzyme of Mycobacterium smegmatis.  Guerin ME, Kaur D, Somashekar BS, Gibbs S, Gest P, Chatterjee D, Brennan PJ, Jackson M.  J Biol Chem. 2009 Sep 18;284(38):25687-96.

Population-based molecular epidemiology of leprosy in Cebu, Philippines.  Sakamuri RM, Kimura M, Li W, Kim HC, Lee H, Kiran MD, Black WC 4th, Balagon M, Gelber R, Cho SN, Brennan PJ, Vissa V.  J Clin Microbiol. 2009 Sep;47(9):2844-54.

Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria.  Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson M.  PLoS One. 2009;4(5):e5447.

Rapid variable-number tandem-repeat genotyping for Mycobacterium leprae clinical specimens.  Kimura M, Sakamuri RM, Groathouse NA, Rivoire BL, Gingrich D, Krueger-Koplin S, Cho SN, Brennan PJ, Vissa V.  J Clin Microbiol. 2009 Jun;47(6):1757-66.

Defining mycobacteria: Shared and specific genome features for different lifestyles.  Vissa VD, Sakamuri RM, Li W, Brennan PJ.  Indian J Microbiol. 2009 Mar;49(1):11-47. doi: 10.1007/s12088-009-0006-0.

Heparin-binding hemagglutinin (HBHA) of Mycobacterium leprae is expressed during infection and enhances bacterial adherence to epithelial cells.  de Lima CS, Marques MA, Debrie AS, Almeida EC, Silva CA, Brennan PJ, Sarno EN, Menozzi FD, Pessolani MC.  FEMS Microbiol Lett. 2009 Mar;292(2):162-9.

IFNgamma response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia.  del Corral H, París SC, Marín ND, Marín DM, López L, Henao HM, Martínez T, Villa L, Barrera LF, Ortiz BL, Ramírez ME, Montes CJ, Oquendo MC, Arango LM, Riaño F, Aguirre C, Bustamante A, Belisle JT, Dobos K, Mejía GI, Giraldo MR, Brennan PJ, Robledo J, Arbeláez MP, Rojas CA, García LF.  PLoS One. 2009 Dec 14;4(12):e8257.

Characterisation of short tandem repeats for genotyping Mycobacterium leprae.  Gillis T, Vissa V, Matsuoka M, Young S, Richardus JH, Truman R, Hall B, Brennan P; Ideal Consortium Partners.  Lepr Rev. 2009 Sep;80(3):250-60.

Genetic diversity of mycobacterium leprae isolates from Brazilian leprosy patients. Fontes AN, Sakamuri RM, Baptista IM, Ura S, Moraes MO, Martínez AN, Sarno EN, Brennan PJ, Vissa VD, Suffys PN.  Lepr Rev. 2009 Sep;80(3):302-15.

Molecular epidemiology of leprosy based on VNTR typing in Thailand.  Srisungnam S, Rudeeaneksin J, Lukebua A, Wattanapokayakit S, Pasadorn S, Mahotarn K, Ajincholapan, Sakamuri RM, Kimura M, Brennan PJ, Phetsuksiri B, Vissa V.  Lepr Rev. 2009 Sep;80(3):280-9.

A continuation: study and characterisation of Mycobacterium leprae short tandem repeat genotypes and transmission of leprosy in Cebu, Philippines.  Sakamuri RM, Harrison J, Gelber R, Saunderson P, Brennan PJ, Balagon M, Vissa V.  Lepr Rev. 2009 Sep;80(3):272-9.

IDEAL: in the footsteps of IMMLEP and THELEP.  Brennan PJ.  Lepr Rev. 2009 Sep;80(3):236-45.

Peptides of a novel Mycobacterium tuberculosis-specific cell wall protein for immunodiagnosis of tuberculosis.  Singh KK, Sharma N, Vargas D, Liu Z, Belisle JT, Potharaju V, Wanchu A, Behera D, Laal S.  J Infect Dis. 2009 Aug 15;200(4):571-81.

Isosation of mycobacterium species genomic DNA.  Belisle JT, Mahaffey SB, Hill PJ.  Methods Mol Biol. 2009;465:1-12.

Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis.  Slayden RA, Belisle JT.  J Antimicrob Chemother. 2009 Mar;63(3):451-7.

N-Terminal clustering of the O-glycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC.  Sartain MJ, Belisle JT.  Glycobiology. 2009 Jan;19(1):38-51.

TLR2 looks at lipoproteins.  Schenk M, Belisle JT, Modlin RL.  Immunity. 2009 Dec 18;31(6):847-9.

Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis.  Sharpe SA, Eschelbach E, Basaraba RJ, Gleeson F, Hall GA, McIntyre A, Williams A, Kraft SL, Clark S, Gooch K, Hatch G, Orme IM, Marsh PD, Dennis MJ.  Tuberculosis (Edinb). 2009 Nov;89(6):405-16.

Post-exposure vaccination against Mycobacterium tuberculosis.  Henao-Tamayo M, Palaniswamy GS, Smith EE, Shanley CA, Wang B, Orme IM, Basaraba RJ, DuTeau NM, Ordway D.  Tuberculosis (Edinb). 2009 Mar;89(2):142-8.

Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs.  Palanisamy GS, DuTeau N, Eisenach KD, Cave DM, Theus SA, Kreiswirth BN, Basaraba RJ, Orme IM.  Tuberculosis (Edinb). 2009 May;89(3):203-9.

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys.  Reed SG, Coler RN, Dalemans W, Tan EV, DeLa Cruz EC, Basaraba RJ, Orme IM, Skeiky YA, Alderson MR, Cowgill KD, Prieels JP, Abalos RM, Dubois MC, Cohen J, Mettens P, Lobet Y.  Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2301-6. Epub 2009 Feb 2. Erratum in: Proc Natl Acad Sci U S A.2009 May 5;106(18):7678. Dalemans, Wilifred [corrected to Dalemans, Wilfried].

Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Eoh H, Narayanasamy P, Brown AC, Parish T, Brennan PJ, Crick DC Chem Biol. 2009 Dec 24;16(12):1230-9.

MenA is a promising drug target for developing novel lead molecules to combat Mycobacterium tuberculosis. Kurosu M, Crick DC. Med Chem. 2009 Mar;5(2):197-207.

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence. Dhiman RK, Mahapatra S, Slayden RA, Boyne ME, Lenaerts A, Hinshaw JC, Angala SK, Chatterjee D, Biswas K, Narayanasamy P, Kurosu M, Crick DC. Mol Microbiol. 2009 Apr;72(1):85-97.

Rapid screening of inhibitors of Mycobacterium tuberculosis growth using tetrazolium salts. Amin AG, Angala SK, Chatterjee D, Crick DC. Methods Mol Biol. 2009;465:187-201.

Implications of high level pseudogene transcription in Mycobacterium leprae.  Williams DL, Slayden RA, Amin A, Martinez AN, Pittman TL, Mira A, Mitra A, Nagaraja V, Morrison NE, Moraes M, Gillis TP.  BMC Genomics. 2009 Aug 25;10:397.

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.  Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE.  Bioorg Med Chem. 2009 May 15;17(10):3588-94.

Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.  Lu H, England K, am Ende C, Truglio JJ, Luckner S, Reddy BG, Marlenee NL, Knudson SE, Knudson DL, Bowen RA, Kisker C, Slayden RA, Tonge PJ.  ACS Chem Biol. 2009 Mar 20;4(3):221-31.

Evaluation of new vaccines for tuberculosis in the guinea pig model.  Williams A, Hall Y, Orme IM.  Tuberculosis (Edinb). 2009 Nov;89(6):389-97.

Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry.  Early MA, Lishnevsky M, Gilchrist JM, Higgins DM, Orme IM, Muller WA, Gonzalez-Juarerro M, Schenkel AR.  Exp Mol Pathol. 2009 Oct;87(2):152-8.

Potential complications to TB vaccine testing in animal models.  Orme IM.  Indian J Exp Biol. 2009 Jun;47(6):440-4.

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning.  Coler RN, Dillon DC, Skeiky YA, Kahn M, Orme IM, Lobet Y, Reed SG, Alderson MR. Vaccine. 2009 Jan 7;27(2):223-33. doi: 10.1016/j.vaccine.2008.10.056.

Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.  Woolhiser LK, Hoff DR, Marietta KS, Orme IM, Lenaerts AJ.  Antimicrob Agents Chemother. 2009 Jan;53(1):306-8.

Suppression of IFNgamma+mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression.  Morris KR, Lutz RD, Bai X, McGibney MT, Cook D, Ordway D, Chan ED.  Tuberculosis (Edinb). 2009 Jul;89(4):294-303.

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.  O’Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.  J Nat Prod. 2009 Mar 27;72(3):360-5.

High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors.  Christophe T, Jackson M, Jeon HK, Fenistein D, Contreras-Dominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Kim EH, Lee SY, Kang S, Seo MJ, Park EJ, Skovierová H, Pham H, Riccardi G, Nam JY, Marsollier L, Kempf M, Joly-Guillou ML, Oh T, Shin WK, No Z, Nehrbass U, Brosch R, Cole ST, Brodin P.  PLoS Pathog. 2009 Oct;5(10):e1000645.

Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.  Svetlíková Z, Skovierová H, Niederweis M, Gaillard JL, McDonnell G, Jackson M.  Antimicrob Agents Chemother. 2009 Sep;53(9):4015-8.

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis.  Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM.  J Biol Chem. 2009 Aug 7;284(32):21613-25. Epub 2009 Jun 11.

Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis.  de la Paz Santangelo M, Klepp L, Nuñez-García J, Blanco FC, Soria M, García-Pelayo MC, Bianco MV, Cataldi AA, Golby P, Jackson M, Gordon SV, Bigi F.  Microbiology. 2009 Jul;155(Pt 7):2245-55.

Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.  Hoff DR, Caraway ML, Brooks EJ, Driver ER, Ryan GJ, Peloquin CA, Orme IM, Basaraba RJ, Lenaerts AJ.  Antimicrob Agents Chemother. 2008 Nov;52(11):4137-40..

Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis.  Ordway D, Henao-Tamayo M, Shanley C, Smith EE, Palanisamy G, Wang B, Basaraba RJ, Orme IM.  Clin Vaccine Immunol. 2008 Aug;15(8):1248-58.

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.  Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Higgins JR, Lee EJ, Orme IM, Gonzalez-Juarrero M.  J Immunol. 2008 Apr 1;180(7):4892-900.

Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model.  Palanisamy GS, Smith EE, Shanley CA, Ordway DJ, Orme IM, Basaraba RJ.  Tuberculosis (Edinb). 2008 Jul;88(4):295-306.

Animal model of Mycobacterium abscessus lung infection.  Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt J, Bai X, Basaraba RJ, Orme IM, Chan ED.  J Leukoc Biol. 2008 Jun;83(6):1502-11..

Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.  Lenaerts AJ, Bitting C, Woolhiser L, Gruppo V, Marietta KS, Johnson CM, Orme IM.  Antimicrob Agents Chemother. 2008 Apr;52(4):1513-5.

Preclinical testing of new drugs for tuberculosis: current challenges.  Lenaerts AJ, Degroote MA, Orme IM.  Trends Microbiol. 2008 Feb;16(2):48-54.

Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig.  Basaraba RJ, Bielefeldt-Ohmann H, Eschelbach EK, Reisenhauer C, Tolnay AE, Taraba LC, Shanley CA, Smith EA, Bedwell CL, Chlipala EA, Orme IM.  Tuberculosis (Edinb). 2008 Jan;88(1):69-79.

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.  Respicio L, Nair PA, Huang Q, Anil B, Tracz S, Truglio JJ, Kisker C, Raleigh DP, Ojima I, Knudson DL, Tonge PJ, Slayden RA.  Tuberculosis (Edinb). 2008 Sep;88(5):420-9.

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.  am Ende CW, Knudson SE, Liu N, Childs J, Sullivan TJ, Boyne M, Xu H, Gegina Y, Knudson DL, Johnson F, Peloquin CA, Slayden RA, Tonge PJ.  Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33.

A new Mycobacterium species causing diffuse lepromatous leprosy.  Han XY, Seo YH, Sizer KC, Schoberle T, May GS, Spencer JS, Li W, Nair RG.  Am J Clin Pathol. 2008 Dec;130(6):856-64.

Deciphering the proteomic profile of Mycobacterium leprae cell envelope.  Marques MA, Neves-Ferreira AG, da Silveira EK, Valente RH, Chapeaurouge A, Perales J, da Silva Bernardes R, Dobos KM, Spencer JS, Brennan PJ, Pessolani MC.  Proteomics. 2008 Jun;8(12):2477-91.

Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis.  Huang H, Berg S, Spencer JS, Vereecke D, D’Haeze W, Holsters M, McNeil MR.  Microbiology. 2008 Mar;154(Pt 3):736-43.

Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection.  Taylor JL, Bielefeldt-Ohmann H, Pozzi A, Izzo AA.  Tuberculosis (Edinb). 2008 Sep;88(5):444-52.

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.  Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL.  J Immunol. 2008 May 1;180(9):5833-42.

Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability.  Shi L, Zhou R, Liu Z, Lowary TL, Seeberger PH, Stocker BL, Crick DC, Khoo KH, Chatterjee D.  J Bacteriol. 2008 Aug;190(15):5248-55.

The critical role of embC in Mycobacterium tuberculosis.  Goude R, Amin AG, Chatterjee D, Parish T.  J Bacteriol. 2008 Jun;190(12):4335-41..

Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare.  Fujiwara N, Nakata N, Naka T, Yano I, Doe M, Chatterjee D, McNeil M, Brennan PJ, Kobayashi K, Makino M, Matsumoto S, Ogura H, Maeda S.  J Bacteriol. 2008 May;190(10):3613-21.

The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactan.  Bhamidi S, Scherman MS, Rithner CD, Prenni JE, Chatterjee D, Khoo KH, McNeil MR. J Biol Chem. 2008 May 9;283(19):12992-3000.

EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis.  Amin AG, Goude R, Shi L, Zhang J, Chatterjee D, Parish T.  Microbiology. 2008 Jan;154(Pt 1):240-8.

Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis.  Gest P, Kaur D, Pham HT, van der Woerd M, Hansen E, Brennan PJ, Jackson M, Guerin ME.  Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1121-4.

Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferase.  Kaur D, Obregón-Henao A, Pham H, Chatterjee D, Brennan PJ, Jackson M.  Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17973-7.

Genotyping North American animal Mycobacterium bovis isolates using multilocus variable number tandem repeat analysis.  Martinez LR, Harris B, Black WC 4th, Meyer RM, Brennan PJ, Vissa VD, Jones RL.  J Vet Diagn Invest. 2008 Nov;20(6):707-15.

Molecular methods for distinguishing between relapse and reinfection in leprosy.  Oskam L, Dockrell HM, Brennan PJ, Gillis T, Vissa V, Richardus JH; IDEAL Consortium.  Trop Med Int Health. 2008 Oct;13(10):1325-6.

Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.  Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, Schlesinger LS.  J Biol Chem. 2008 Nov 14;283(46):31417-28.

LightCycler real-time PCR for rapid detection and quantitation of Mycobacterium leprae in skin specimens.  Rudeeaneksin J, Srisungngam S, Sawanpanyalert P, Sittiwakin T, Likanonsakul S, Pasadorn S, Palittapongarnpim P, Brennan PJ, Phetsuksiri B.  FEMS Immunol Med Microbiol. 2008 Nov;54(2):263-70.

Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?  Monot M, Honoré N, Balière C, Ji B, Sow S, Brennan PJ, Cole ST.  J Clin Microbiol. 2008 Jul;46(7):2291-7.

N-D-aldopentofuranosyl-N’-[p-(isoamyloxy)phenyl]-thiourea derivatives: potential anti-TB therapeutic agents.  Liav A, Angala SK, Brennan PJ, Jackson M.  Bioorg Med Chem Lett. 2008 Apr 15;18(8):2649-51.

Galactosyl transferases in mycobacterial cell wall synthesis.  Belánová M, Dianisková P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusová K.  J Bacteriol. 2008 Feb;190(3):1141-5.

Unique structural features of the peptidoglycan of Mycobacterium leprae.  Mahapatra S, Crick DC, McNeil MR, Brennan PJ.  J Bacteriol. 2008 Jan;190(2):655-61

Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country.  Wanchu A, Dong Y, Sethi S, Myneedu VP, Nadas A, Liu Z, Belisle J, Laal S.  PLoS One. 2008 Apr 30;3(4):e2071.

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.  El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, König T, Schleicher U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, Bogdan C, Wynn TA, Murray PJ.  Nat Immunol. 2008 Dec;9(12):1399-406.

Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase. Noike M, Ambo T, Kikuchi S, Suzuki T, Yamashita S, Takahashi S, Kurokawa H, Mahapatra S, Crick DC, Koyama T. Biochem Biophys Res Commun. 2008 Dec 5;377(1):17-22.

Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.

The structural basis of chain length control in Rv1086. Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH. J Mol Biol. 2008 Aug 1;381(1):129-40. Epub 2008 Jul 1.

Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase. Zhang W, Jones VC, Scherman MS, Mahapatra S, Crick D, Bhamidi S, Xin Y, McNeil MR, Ma Y. Int J Biochem Cell Biol. 2008;40(11):2560-71.

Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL. Grzegorzewicz AE, Ma Y, Jones V, CrickD, Liav A, McNeil MR. Microbiology. 2008 Dec;154(Pt 12):3724-30.

Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy.  Honaker RW, Stewart A, Schittone S, Izzo A, Klein MR, Voskuil MI.  Infect Immun. 2008 Jun;76(6):2587-93.

Mycobacterial infection induces the secretion of high-mobility group box 1 protein.  Grover A, Taylor J, Troudt J, Keyser A, Sommersted K, Schenkel A, Izzo AA.  Cell Microbiol. 2008 Jun;10(6):1390-404.

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.  Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R, Vesosky B, Turner J.  J Immunol. 2008 Oct 15;181(8):5545-50.

Partial redundancy in the synthesis of the D-arabinose incorporated in the cell wall arabinan of Corynebacterineae.  Meniche X, de Sousa-d’Auria C, Van-der-Rest B, Bhamidi S, Huc E, Huang H, De Paepe D, Tropis M, McNeil M, Daffé M, Houssin C.  Microbiology. 2008 Aug;154(Pt 8):2315-26.

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.  Hurdle JG, Lee RB, Budha NR, Carson EI, Qi J, Scherman MS, Cho SH, McNeil MR, Lenaerts AJ, Franzblau SG, Meibohm B, Lee RE.  J Antimicrob Chemother. 2008 Nov;62(5):1037-45.

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.  Vicente E, Villar R, Burguete A, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.  Antimicrob Agents Chemother. 2008 Sep;52(9):3321-6.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.  Villar R, Vicente E, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.  J Antimicrob Chemother. 2008 Sep;62(3):547-54.

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics.  Fonvielle M, Coinçon M, Daher R, Desbenoit N, Kosieradzka K, Barilone N, Gicquel B, Sygusch J, Jackson M, Therisod M.  Chemistry. 2008;14(28):8521-9.

The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface.  Pitarque S, Larrouy-Maumus G, Payré B, Jackson M, Puzo G, Nigou J.  Tuberculosis (Edinb). 2008 Nov;88(6):560-5. Epub 2008 Jun 9.

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.  Chesne-Seck ML, Barilone N, Boudou F, Gonzalo Asensio J, Kolattukudy PE, Martín C, Cole ST, Gicquel B, Gopaul DN, Jackson M.  J Bacteriol. 2008 Feb;190(4):1329-34.

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.  Sambou T, Dinadayala P, Stadthagen G, Barilone N, Bordat Y, Constant P, Levillain F, Neyrolles O, Gicquel B, Lemassu A, Daffé M, Jackson M.  Mol Microbiol. 2008 Nov;70(3):762-74.