A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome. Silva CAM, Andre BG, Webb K, Ashton LV, Harton M, Luetkemeyer A, Bokatzian S, Almubarak R, Mahapatra S, Hovind L, Kendall MA, Havlir D, Belisle JT, De Groote MA. Int J Infect Dis. 2019 Apr 19. pii: S1201-9712(19)30185-7. doi: 10.1016/j.ijid.2019.04.015. PMID: 31009738

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study. Penn-Nicholson A, Hraha T, Thompson EG, Sterling D, Mbandi SK, Wall KM, Fisher M, Suliman S, Shankar S, Hanekom WA, Janjic N, Hatherill M, Kaufmann SHE, Sutherland J, Walzl G, De Groote MA, Ochsner U, Zak DE, Scriba TJ; ACS and GC6–74 cohort study groups. PLoS Med. 2019 Apr 16;16(4):e1002781. doi: 10.1371/journal.pmed.1002781. eCollection 2019 Apr. PMID: 30990820

Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research. Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, Sacchettini JC, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM. Am J Respir Crit Care Med. 2019 Apr 15;199(8):947-951. doi: 10.1164/rccm.201807-1273PP. No abstract available. PMID: 30428263

Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis. Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DC. PLoS One. 2019 Apr 12;14(4):e0214958. doi: 10.1371/journal.pone.0214958. eCollection 2019. PMID: 30978223

Mycobacterium avium Infection in a C3HeB/FeJ Mouse Model. Verma D, Stapleton M, Gadwa J, Vongtongsalee K, Schenkel AR, Chan ED, Ordway D. Front Microbiol. 2019 Apr 3;10:693. doi: 10.3389/fmicb.2019.00693. eCollection 2019. PMID: 31001241

Fingerstick test quantifying humoral and cellular biomarkers indicative for M. leprae infection. Corstjens PLAM, van Hooij A, Tjon Kon Fat EM, Alam K, Vrolijk LB, Dlamini S, da Silva MB, Spencer JS, Salgado CG, Richardus JH, van Hees CLM, Geluk A. Clin Biochem. 2019 Apr;66:76-82. doi: 10.1016/j.clinbiochem.2019.01.007. Epub 2019 Jan 26. PMID: 30695682

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds. Li W, Stevens CM, Pandya AN, Darzynkiewicz Z, Bhattarai P, Tong W, Gonzalez-Juarrero M, North EJ, Zgurskaya HI, Jackson M. ACS Infect Dis. 2019 Mar 28. doi: 10.1021/acsinfecdis.9b00048. [Epub ahead of print] PMID: 30882198

Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model. Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ. Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02071-18. doi: 10.1128/AAC.02071-18. Print 2019 Apr. PMID: 30745397

Elucidation of a Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy. Fitzgerald BL, Islam MN, Graham B, Mahapatra S, Webb K, Boom WH, Malherbe ST, Joloba ML, Johnson JL, Winter J, Walzl G, Belisle JT. ACS Infect Dis. 2019 Mar 8;5(3):353-364. doi: 10.1021/acsinfecdis.8b00241. Epub 2019 Jan 10. PMID: 30585483

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.
Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P. Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available. PMID: 30335466

Activation of S6 signaling is associated with cell survival and multinucleation in hyperplastic skin after epidermal loss of AURORA-A Kinase. Ryan WK, Fernandez J, Peterson MK, Sheneman DW, Podell BK, De S, Torchia EC. Cell Death Differ. 2019 Mar;26(3):548-564. doi: 10.1038/s41418-018-0167-7. Epub 2018 Jul 26. PMID: 30050055

Evaluation of liposome toll-like receptor ligand complexes for non-specific mucosal immunoprotection from feline herpesvirus-1 infection.  Contreras ET, Olea-Popelka F, Wheat W, Dow S, Hawley J, Lappin MR. J Vet Intern Med. 2019 Mar;33(2):831-837. doi: 10.1111/jvim.15427. Epub 2019 Mar 7. PMID: 30847973

Mycobacteria and their sweet proteins: An overview of protein glycosylation and lipoglycosylation in M. tuberculosis. Mehaffy C, Belisle JT, Dobos KM. Tuberculosis (Edinb). 2019 Mar;115:1-13. doi: 10.1016/j.tube.2019.01.001. Epub 2019 Jan 14. Review. PMID: 30948163

Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection. Pandya AN, Prathipati PK, Hegde P, Li W, Graham KF, Mandal S, Drescher KM, Destache CJ, Ordway D, Jackson M, North EJ. Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02245-18. doi: 10.1128/AAC.02245-18. Print 2019 Mar. PMID: 30602519

The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases. Baldwin SL, Larsen SE, Ordway D, Cassell G, Coler RN. PLoS Negl Trop Dis. 2019 Feb 14;13(2):e0007083. doi: 10.1371/journal.pntd.0007083. eCollection 2019 Feb. Review. PMID: 30763316

Biomarkers for tuberculosis: the case for lipoarabinomannan. Correia-Neves M, Fröberg G, Korshun L, Viegas S, Vaz P, Ramanlal N, Bruchfeld J, Hamasur B, Brennan P, Källenius G. ERJ Open Res. 2019 Feb 11;5(1). pii: 00115-2018. doi: 10.1183/23120541.00115-2018. eCollection 2019 Feb. Review. PMID: 30775376

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis. Lu X, Williams Z, Hards K, Tang J, Cheung CY, Aung HL, Wang B, Liu Z, Hu X, Lenaerts A, Woolhiser L, Hastings C, Zhang X, Wang Z, Rhee K, Ding K, Zhang T, Cook GM. ACS Infect Dis. 2019 Feb 8;5(2):239-249. doi: 10.1021/acsinfecdis.8b00225. Epub 2018 Dec 11. PMID: 30485737

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain.  Jeon AB, Ackart DF, Li W, Jackson M, Melander RJ, Melander C, Abramovitch RB, Chicco AJ, Basaraba RJ, Obregón-Henao A. Sci Rep. 2019 Feb 6;9(1):1513. doi: 10.1038/s41598-018-38064-7. PMID: 30728417

Mechanism of Fluorinated Anthranilate-Induced Growth Inhibition in Mycobacterium tuberculosis.  Nurul Islam M, Hitchings R, Kumar S, Fontes FL, Lott JS, Kruh-Garcia NA, Crick DC. ACS Infect Dis. 2019 Jan 11;5(1):55-62. doi: 10.1021/acsinfecdis.8b00092. Epub 2018 Nov 26. PMID: 30406991

Detection of the tuberculosis biomarker mannose-capped lipoarabinomannan in human serum: Impact of sample pretreatment with perchloric acid.  Owens NA, Young CC, Laurentius LB, De P, Chatterjee D, Porter MD. Anal Chim Acta. 2019 Jan 10;1046:140-147. doi: 10.1016/j.aca.2018.09.037. Epub 2018 Sep 18. PMID: 30482291

Characterization of Arabinosyl Transfer Reactions in the Biosynthesis of Mycobacterial Cell Envelope (Lipo)Polysaccharides. Angala SK, Jackson M. Methods Mol Biol. 2019;1954:175-186. doi: 10.1007/978-1-4939-9154-9_14. PMID: 30864132

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice. Rathi C, Lukka PB, Wagh S, Lee RE, Lenaerts AJ, Braunstein M, Hickey A, Gonzalez-Juarrero M, Meibohm B. Tuberculosis (Edinb). 2019 Jan;114:119-122. doi: 10.1016/j.tube.2018.12.006. Epub 2018 Dec 31. PMID: 30711150

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions. Negera E, Tilahun M, Bobosha K, Lambert SM, Walker SL, Spencer JS, Aseffa A, Dockrell HM, Lockwood DN. PLoS Negl Trop Dis. 2018 Dec 28;12(12):e0007035. doi: 10.1371/journal.pntd.0007035. eCollection 2018 Dec. PMID: 30592714

Evaluation of Immunodiagnostic Tests for Leprosy in Brazil, China and Ethiopia. van Hooij A, Tjon Kon Fat EM, Batista da Silva M, Carvalho Bouth R, Cunha Messias AC, Gobbo AR, Lema T, Bobosha K, Li J, Weng X, Salgado CG, Spencer JS, Corstjens PLAM, Geluk A. Sci Rep. 2018 Dec 18;8(1):17920. doi: 10.1038/s41598-018-36323-1. PMID: 30560920

Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15. Cambau E, Saunderson P, Matsuoka M, Cole ST, Kai M, Suffys P, Rosa PS, Williams D, Gupta UD, Lavania M, Cardona-Castro N, Miyamoto Y, Hagge D, Srikantam A, Hongseng W, Indropo A, Vissa V, Johnson RC, Cauchoix B, Pannikar VK, Cooreman EAWD, Pemmaraju VRR, Gillini L; WHO surveillance network of antimicrobial resistance in leprosy. Clin Microbiol Infect. 2018 Dec;24(12):1305-1310. doi: 10.1016/j.cmi.2018.02.022. Epub 2018 Mar 1. PMID: 29496597

Measuring antigen-specific responses in Mycobacterium bovis-infected warthogs (Phacochoerus africanus) using the intradermal tuberculin test. Roos EO, Olea-Popelka F, Buss P, Hausler GA, Warren R, van Helden PD, Parsons SDC, de Klerk-Lorist LM, Miller MA. BMC Vet Res. 2018 Nov 20;14(1):360. doi: 10.1186/s12917-018-1685-8. PMID: 30458774

Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates. Samart N, Arhouma Z, Kumar S, Murakami HA, Crick DC, Crans DC. Front Chem. 2018 Nov 20;6:519. doi: 10.3389/fchem.2018.00519. eCollection 2018. PMID: 30515375

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2. Decout A, Silva-Gomes S, Drocourt D, Blattes E, Rivière M, Prandi J, Larrouy-Maumus G, Caminade AM, Hamasur B, Källenius G, Kaur D, Dobos KM, Lucas M, Sutcliffe IC, Besra GS, Appelmelk BJ, Gilleron M, Jackson M, Vercellone A, Tiraby G, Nigou J. Sci Rep. 2018 Nov 15;8(1):16840. doi: 10.1038/s41598-018-35393-5. PMID: 30443026

High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types. Blanc L, Daudelin IB, Podell BK, Chen PY, Zimmerman M, Martinot AJ, Savic RM, Prideaux B, Dartois V. Elife. 2018 Nov 14;7. pii: e41115. doi: 10.7554/eLife.41115. PMID: 30427309

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway. Upadhyay R, Sanchez-Hidalgo A, Wilusz CJ, Lenaerts AJ, Arab J, Yeh J, Stefanisko K, Tarasova NI, Gonzalez-Juarrero M. Sci Rep. 2018 Nov 9;8(1):16610. doi: 10.1038/s41598-018-35023-0. PMID: 30413750

Discovery of benzothiazole amides as potent antimycobacterial agents. Graham J, Wong CE, Day J, McFaddin E, Ochsner U, Hoang T, Young CL, Ribble W, DeGroote MA, Jarvis T, Sun X. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3177-3181. doi: 10.1016/j.bmcl.2018.08.026. Epub 2018 Aug 25. PMID: 30172617

Standardized guinea pig model for Q fever vaccine reactogenicity. Baeten LA, Podell BK, Sluder AE, Garritsen A, Bowen RA, Poznansky MC. PLoS One. 2018 Oct 12;13(10):e0205882. doi: 10.1371/journal.pone.0205882. eCollection 2018. PMID: 30312355

Topical therapy for refractory rhinosinusitis caused by methicillin-resistant Staphylococcus aureus: First report in a prospective series. Shikani AH, Khoueir N, Jabra-Rizk MA, Shikani HJ, Basaraba RJ, Leid JG. Auris Nasus Larynx. 2018 Oct;45(5):994-999. doi: 10.1016/j.anl.2018.01.009. Epub 2018 Feb 6. PMID: 29426723

Seroprevalence of Mycobacterium bovis infection in warthogs (Phacochoerus africanus) in bovine tuberculosis-endemic regions of South Africa. Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, van Helden PD, Parsons SDC, Miller MA. Transbound Emerg Dis. 2018 Oct;65(5):1182-1189. doi: 10.1111/tbed.12856. Epub 2018 Mar 8. PMID: 29520985

Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis. Upadhyay A, Kumar S, Rooker SA, Koehn JT, Crans DC, McNeil MR, Lott JS, Crick DC. ACS Chem Biol. 2018 Sep 21;13(9):2498-2507. doi: 10.1021/acschembio.8b00402. Epub 2018 Aug 27. PMID: 30091899

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent. De Groote MA, Jackson M, Gonzalez-Juarrero M, Li W, Young CL, Wong C, Graham J, Day J, Hoang T, Jarvis TC, Ribble W, Sun X, Ochsner UA. Front Microbiol. 2018 Sep 20;9:2231. doi: 10.3389/fmicb.2018.02231. eCollection 2018. PMID: 30294313

Biochemical Characterization of Isoniazid-resistant <i>Mycobacterium tuberculosis:</i> Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?
Nieto R LM, Mehaffy C, Islam MN, Fitzgerald B, Belisle J, Prenni J, Dobos K. Mol Cell Proteomics. 2018 Sep;17(9):1685-1701. doi: 10.1074/mcp.RA118.000821. Epub 2018 May 29. PMID: 29844232

Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola. Long JJ, Jahn CE, Sánchez-Hidalgo A, Wheat W, Jackson M, Gonzalez-Juarrero M, Leach JE. PLoS One. 2018 Aug 24;13(8):e0202941. doi: 10.1371/journal.pone.0202941. eCollection 2018. PMID: 30142182

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Mycobacterium tuberculosis. Santos K, Lukka PB, Grzegorzewicz A, Jackson M, Trivedi A, Pavan F, Chorilli M, Braunstein M, Hickey A, Meibohm B, Gonzalez-Juarrero M. Front Microbiol. 2018 Aug 21;9:1895. doi: 10.3389/fmicb.2018.01895. eCollection 2018. PMID: 30186246

Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity. Gullberg RC, Steel JJ, Pujari V, Rovnak J, Crick DC, Perera R. PLoS Pathog. 2018 Aug 17;14(8):e1007261. doi: 10.1371/journal.ppat.1007261. eCollection 2018 Aug. PMID: 30118512

Identification of Urine Metabolites as Biomarkers of Early Lyme Disease. Pegalajar-Jurado A, Fitzgerald BL, Islam MN, Belisle JT, Wormser GP, Waller KS, Ashton LV, Webb KJ, Delorey MJ, Clark RJ, Molins CR. Sci Rep. 2018 Aug 15;8(1):12204. doi: 10.1038/s41598-018-29713-y. PMID: 30111850

Impact of immunopathology on the antituberculous activity of pyrazinamide. Blanc L, Sarathy JP, Alvarez Cabrera N, O’Brien P, Dias-Freedman I, Mina M, Sacchettini J, Savic RM, Gengenbacher M, Podell BK, Prideaux B, Ioerger T, Dick T, Dartois V. J Exp Med. 2018 Aug 6;215(8):1975-1986. doi: 10.1084/jem.20180518. Epub 2018 Jul 17. PMID: 30018074

Analogue synthesis reveals decoupling of antibiofilm and β-lactam potentiation activities of a lead 2-aminoimidazole adjuvant against Mycobacterium smegmatis. Martin SE, Nguyen CM, Basaraba RJ, Melander C. Chem Biol Drug Des. 2018 Aug;92(2):1403-1408. doi: 10.1111/cbdd.13208. Epub 2018 May 12. PMID: 29663670

Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1. Higgins JL, Bowen RA, Gonzalez-Juarrero M. Vet Immunol Immunopathol. 2018 Aug;202:74-84. doi: 10.1016/j.vetimm.2018.06.004. Epub 2018 Jun 18. PMID: 30078602

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections. Li W, Yazidi A, Pandya AN, Hegde P, Tong W, Calado Nogueira de Moura V, North EJ, Sygusch J, Jackson M. Front Microbiol. 2018 Jul 10;9:1547. doi: 10.3389/fmicb.2018.01547. eCollection 2018. PMID: 30042757

Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction Study of Dolutegravir With Once-Weekly Isoniazid and Rifapentine. Brooks KM, George JM, Pau AK, Rupert A, Mehaffy C, De P, Dobos KM, Kellogg A, McLaughlin M, McManus M, Alfaro RM, Hadigan C, Kovacs JA, Kumar P. Clin Infect Dis. 2018 Jul 2;67(2):193-201. doi: 10.1093/cid/ciy082. PMID: 29415190

Handheld Raman Spectrometer Instrumentation for Quantitative Tuberculosis Biomarker Detection: A Performance Assessment for Point-of-Need Infectious Disease Diagnostics. Owens NA, Laurentius LB, Porter MD, Li Q, Wang S, Chatterjee D. Appl Spectrosc. 2018 Jul;72(7):1104-1115. doi: 10.1177/0003702818770666. Epub 2018 Apr 17. PMID: 29664331

Detection of lipoarabinomannan in urine and serum of HIV-positive and HIV-negative TB suspects using an improved capture-enzyme linked immuno absorbent assay and gas chromatography/mass spectrometry. Amin AG, De P, Spencer JS, Brennan PJ, Daum J, Andre BG, Joe M, Bai Y, Laurentius L, Porter MD, Honnen WJ, Choudhary A, Lowary TL, Pinter A, Chatterjee D. Tuberculosis (Edinb). 2018 Jul;111:178-187. doi: 10.1016/j.tube.2018.06.004. Epub 2018 Jun 6. PMID: 30029905

IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus). Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, Warren RM, van Helden PD, Parsons SDC, Miller MA. Vet Immunol Immunopathol. 2018 Jul;201:43-48. doi: 10.1016/j.vetimm.2018.05.007. Epub 2018 May 21. PMID: 29914681

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos. da Silva MB, Portela JM, Li W, Jackson M, Gonzalez-Juarrero M, Hidalgo AS, Belisle JT, Bouth RC, Gobbo AR, Barreto JG, Minervino AHH, Cole ST, Avanzi C, Busso P, Frade MAC, Geluk A, Salgado CG, Spencer JS. PLoS Negl Trop Dis. 2018 Jun 28;12(6):e0006532. doi: 10.1371/journal.pntd.0006532. eCollection 2018 Jun. PMID: 29953440

Modeling and Simulation of Pretomanid Pharmacokinetics in Pulmonary Tuberculosis Patients. Lyons MA. Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e02359-17. doi: 10.1128/AAC.02359-17. Print 2018 Jul. PMID: 29661865

Epidemiologic Evidence of and Potential Mechanisms by Which Second-Hand Smoke Causes Predisposition to Latent and Active Tuberculosis. Bai X, Aerts SL, Verma D, Ordway DJ, Chan ED. Immune Netw. 2018 Jun 26;18(3):e22. doi: 10.4110/in.2018.18.e22. eCollection 2018 Jun. Review. PMID: 29984040

Structural determinants in a glucose-containing lipopolysaccharide from Mycobacterium tuberculosis critical for inducing a subset of protective T cells. De P, McNeil M, Xia M, Boot CM, Hesser DC, Denef K, Rithner C, Sours T, Dobos KM, Hoft D, Chatterjee D. J Biol Chem. 2018 Jun 22;293(25):9706-9717. doi: 10.1074/jbc.RA118.002582. Epub 2018 May 1. PMID: 29716995

Cytokinin Signaling in Mycobacterium tuberculosis. Samanovic MI, Hsu HC, Jones MB, Jones V, McNeil MR, Becker SH, Jordan AT, Strnad M, Xu C, Jackson M, Li H, Darwin KH. MBio. 2018 Jun 19;9(3). pii: e00989-18. doi: 10.1128/mBio.00989-18. PMID: 29921668

The BCGΔBCG1419c Vaccine Candidate Reduces Lung Pathology, IL-6, TNF-α, and IL-10 During Chronic TB Infection. Flores-Valdez MA, Pedroza-Roldán C, Aceves-Sánchez MJ, Peterson EJR, Baliga NS, Hernández-Pando R, Troudt J, Creissen E, Izzo L, Bielefeldt-Ohmann H, Bickett T, Izzo AA. Front Microbiol. 2018 Jun 12;9:1281. doi: 10.3389/fmicb.2018.01281. eCollection 2018. PMID: 29946316

Building a Multi-Institutional and Interdisciplinary Team to Develop a Zoonotic Tuberculosis Roadmap. Olea-Popelka F, Fujiwara PI. Front Public Health. 2018 Jun 12;6:167. doi: 10.3389/fpubh.2018.00167. eCollection 2018. PMID: 29951476

Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry. Prideaux B, Lenaerts A, Dartois V. Curr Opin Chem Biol. 2018 Jun;44:93-100. doi: 10.1016/j.cbpa.2018.05.007. Epub 2018 Jun 27. Review. PMID: 29957376

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O’Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M. Life Sci Alliance. 2018 Jun 1;1(3):e201800025. doi: 10.26508/lsa.201800025. eCollection 2018 Jun. PMID: 30456352

Toxin-antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis. Slayden RA, Dawson CC, Cummings JE. Pathog Dis. 2018 Jun 1;76(4). doi: 10.1093/femspd/fty039. Review. PMID: 29788125

Enhanced Anti-Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment. Larsen SE, Baldwin SL, Orr MT, Reese VA, Pecor T, Granger B, Dubois Cauwelaert N, Podell BK, Coler RN. Vaccines (Basel). 2018 May 24;6(2). pii: E30. doi: 10.3390/vaccines6020030. PMID: 29795025

Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis. Nahid P, Jarlsberg LG, Kato-Maeda M, Segal MR, Osmond DH, Gagneux S, Dobos K, Gold M, Hopewell PC, Lewinsohn DM. PLoS One. 2018 May 22;13(5):e0195392. doi: 10.1371/journal.pone.0195392. eCollection 2018. PMID: 29787561

Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging. Blanc L, Lenaerts A, Dartois V, Prideaux B. Anal Chem. 2018 May 15;90(10):6275-6282. doi: 10.1021/acs.analchem.8b00985. Epub 2018 Apr 26. PMID: 29668262

Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of Mycobacterium tuberculosis, and Complexity of Antibody Specificities toward This Antigen. Choudhary A, Patel D, Honnen W, Lai Z, Prattipati RS, Zheng RB, Hsueh YC, Gennaro ML, Lardizabal A, Restrepo BI, Garcia-Viveros M, Joe M, Bai Y, Shen K, Sahloul K, Spencer JS, Chatterjee D, Broger T, Lowary TL, Pinter A. J Immunol. 2018 May 1;200(9):3053-3066. doi: 10.4049/jimmunol.1701673. Epub 2018 Apr 2. PMID: 29610143

Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network. Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL. J Immunol. 2018 May 1;200(9):3244-3258. doi: 10.4049/jimmunol.1701733. Epub 2018 Apr 2. PMID: 29610140

Protein Digestion, Ultrafiltration, and Size Exclusion Chromatography to Optimize the Isolation of Exosomes from Human Blood Plasma and Serum. Diaz G, Bridges C, Lucas M, Cheng Y, Schorey JS, Dobos KM, Kruh-Garcia NA. J Vis Exp. 2018 Apr 13;(134). doi: 10.3791/57467. PMID: 29708539

Impact of the epoxide hydrolase EphD on the metabolism of mycolic acids in mycobacteria. Madacki J, Laval F, Grzegorzewicz A, Lemassu A, Záhorszká M, Arand M, McNeil M, Daffé M, Jackson M, Lanéelle MA, Korduláková J. J Biol Chem. 2018 Apr 6;293(14):5172-5184. doi: 10.1074/jbc.RA117.000246. Epub 2018 Feb 22. PMID: 29472294

Tuberculosis serosurveillance and management practices of captive African elephants (Loxodonta africana) in the Kavango-Zambezi Transfrontier Conservation Area.
Rosen LE, Hanyire TG, Dawson J, Foggin CM, Michel AL, Huyvaert KP, Miller MA, Olea-Popelka FJ. Transbound Emerg Dis. 2018 Apr;65(2):e344-e354. doi: 10.1111/tbed.12764. Epub 2017 Nov 16. PMID: 29143466

miRNome Expression Analysis Reveals New Players on Leprosy Immune Physiopathology. Salgado CG, Pinto P, Bouth RC, Gobbo AR, Messias ACC, Sandoval TV, Dos Santos AMR, Moreira FC, Vidal AF, Goulart LR, Barreto JG, da Silva MB, Frade MAC, Spencer JS, Santos S, Ribeiro-Dos-Santos Â. Front Immunol. 2018 Mar 9;9:463. doi: 10.3389/fimmu.2018.00463. eCollection 2018. PMID: 29593724

Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis. Orme IM, Henao-Tamayo MI. Front Immunol. 2018 Mar 8;9:461. doi: 10.3389/fimmu.2018.00461. eCollection 2018. Review. PMID: 29568298

Biomarkers for equine joint injury and osteoarthritis. McIlwraith CW, Kawcak CE, Frisbie DD, Little CB, Clegg PD, Peffers MJ, Karsdal MA, Ekman S, Laverty S, Slayden RA, Sandell LJ, Lohmander LS, Kraus VB. J Orthop Res. 2018 Mar;36(3):823-831. doi: 10.1002/jor.23738. Epub 2018 Jan 24. PMID: 28921609

Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission. Shanley CA, Henao-Tamayo MI, Bipin C, Mugasimangalam R, Verma D, Ordway DJ, Streicher EM, Orme IM. Tuberculosis (Edinb). 2018 Mar;109:123-133. doi: 10.1016/j.tube.2018.02.003. Epub 2018 Feb 9. PMID: 29559116

Causes and outcomes of dogs presenting with hyphema to a referral hospital in Colorado: a retrospective analysis of 99 cases. Jinks MR, Olea-Popelka F, Freeman KS. Vet Ophthalmol. 2018 Mar;21(2):160-166. doi: 10.1111/vop.12491. Epub 2017 Aug 6. PMID: 28782234

Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes. Chotiwan N, Andre BG, Sanchez-Vargas I, Islam MN, Grabowski JM, Hopf-Jannasch A, Gough E, Nakayasu E, Blair CD, Belisle JT, Hill CA, Kuhn RJ, Perera R. PLoS Pathog. 2018 Feb 15;14(2):e1006853. doi: 10.1371/journal.ppat.1006853. eCollection 2018 Feb. PMID: 29447265

Covalent modifications of polysaccharides in mycobacteria. Angala SK, Palčeková Z, Belardinelli JM, Jackson M. Nat Chem Biol. 2018 Feb 14;14(3):193-198. doi: 10.1038/nchembio.2571. No abstract available. PMID: 29443974

Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis. Silva CAM, Belisle JT. Front Immunol. 2018 Feb 2;9:134. doi: 10.3389/fimmu.2018.00134. eCollection 2018. Review. PMID: 29472920

Yersinia pestis Survival and Replication in Potential Ameba Reservoir. Markman DW, Antolin MF, Bowen RA, Wheat WH, Woods M, Gonzalez-Juarrero M, Jackson M. Emerg Infect Dis. 2018 Feb;24(2):294-302. doi: 10.3201/eid2402.171065. PMID: 29350155

The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties. Schultz TE, Wiesmüller KH, Lucas M, Dobos KM, Baxter AG, Blumenthal A. J Leukoc Biol. 2018 Feb;103(2):311-319. doi: 10.1002/JLB.2MA0517-190RR. Epub 2018 Jan 9. PMID: 29345364

A roadmap for zoonotic tuberculosis: a One Health approach to ending tuberculosis. Dean AS, Forcella S, Olea-Popelka F, Idrissi AE, Glaziou P, Benyahia A, Mumford E, Erlacher-Vindel E, Gifford G, Lubroth J, Raviglione M, Fujiwara P. Lancet Infect Dis. 2018 Feb;18(2):137-138. doi: 10.1016/S1473-3099(18)30013-6. No abstract available. PMID: 29412954

Are leprosy case numbers reliable? Salgado CG, Barreto JG, da Silva MB, Goulart IMB, Barreto JA, de Medeiros Junior NF, Nery JA, Frade MAC, Spencer JS. Lancet Infect Dis. 2018 Feb;18(2):135-137. doi: 10.1016/S1473-3099(18)30012-4. No abstract available. PMID: 29412953

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae. Benjak A, Avanzi C, Singh P, Loiseau C, Girma S, Busso P, Fontes ANB, Miyamoto Y, Namisato M, Bobosha K, Salgado CG, da Silva MB, Bouth RC, Frade MAC, Filho FB, Barreto JG, Nery JAC, Bührer-Sékula S, Lupien A, Al-Samie AR, Al-Qubati Y, Alkubati AS, Bretzel G, Vera-Cabrera L, Sakho F, Johnson CR, Kodio M, Fomba A, Sow SO, Gado M, Konaté O, Stefani MMA, Penna GO, Suffys PN, Sarno EN, Moraes MO, Rosa PS, Baptista IMFD, Spencer JS, Aseffa A, Matsuoka M, Kai M, Cole ST. Nat Commun. 2018 Jan 24;9(1):352. doi: 10.1038/s41467-017-02576-z. PMID: 29367657

A Synthetic Isoprenoid Lipoquinone, Menaquinone-2, Adopts a Folded Conformation in Solution and at a Model Membrane Interface.
Koehn JT, Magallanes ES, Peters BJ, Beuning CN, Haase AA, Zhu MJ, Rithner CD, Crick DC, Crans DC. J Org Chem. 2018 Jan 5;83(1):275-288. doi: 10.1021/acs.joc.7b02649. Epub 2017 Dec 12. PMID: 29168636

Effect of a Pheromone on Stress-Associated Reactivation of Feline Herpesvirus-1 in Experimentally Inoculated Kittens.
Contreras ET, Hodgkins E, Tynes V, Beck A, Olea-Popelka F, Lappin MR. J Vet Intern Med. 2018 Jan;32(1):406-417. doi: 10.1111/jvim.14894. Epub 2017 Dec 8. PMID: 29219213

Postinduction butorphanol administration alters oxygen consumption to improve blood gases in etorphine-immobilized white rhinoceros.
Buss P, Miller M, Fuller A, Haw A, Stout E, Olea-Popelka F, Meyer L. Vet Anaesth Analg. 2018 Jan;45(1):57-67. doi: 10.1016/j.vaa.2017.03.008. Epub 2017 Apr 17. PMID: 29242121

Van Hooij A, Tjon Kon Fat EM, van den Eeden SJF, Wilson L, Batista da Silva M, Salgado CG, Spencer JS, Corstjens PLAM, Geluk A. Field-friendly serological tests for determination of M. leprae-specific antibodies. Sci Rep. 2017 Aug 21;7(1):8868. doi: 10.1038/s41598-017-07803-7. PMID: 28827673 [PubMed – in process]

Molins CR, Ashton LV, Wormser GP, Andre BG, Hess AM, Delorey MJ, Pilgard MA, Johnson BJ, Webb K, Islam MN, Pegalajar-Jurado A, Molla I, Jewett MW, Belisle JT. Metabolic differentiation of early Lyme disease from southern tick-associated rash illness (STARI). Sci Transl Med. 2017 Aug 16;9(403). pii: eaal2717. doi: 10.1126/scitranslmed.aal2717. PMID: 28814545 [PubMed – indexed for MEDLINE]

Fitzgerald BL, Mahapatra S, Farmer DK, McNeil MR, Casero RA Jr, Belisle JT. Elucidating the Structure of <i>N</i><sup>1</sup>-Acetylisoputreanine: A Novel Polyamine Catabolite in Human Urine. ACS Omega. 2017 Jul 31;2(7):3921-3930. doi: 10.1021/acsomega.7b00872. Epub 2017 Jul 25. PMID: 28782053 [PubMed]

Russell TM, Green LS, Rice T, Kruh-Garcia NA, Dobos K, De Groote MA, Hraha T, Sterling DG, Janjic N, Ochsner UA. Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications. J Clin Microbiol. 2017 Oct;55(10):3072-3088. doi: 10.1128/JCM.00469-17. Epub 2017 Aug 9. PMID: 28794178 [PubMed – in process]

Davidson RM, DeGroote MA, Marola JL, Buss S, Jones V, McNeil MR, Freifeld AG, Elaine Epperson L, Hasan NA, Jackson M, Iwen PC, Salfinger M, Strong M. Mycobacterium talmoniae sp. nov., a slowly growing mycobacterium isolated from human respiratory samples. Int J Syst Evol Microbiol. 2017 Aug;67(8):2640-2645. doi: 10.1099/ijsem.0.001998. Epub 2017 Aug 15. PMID: 28809146 [PubMed – indexed for MEDLINE]

Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ. 2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability. PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017. PMID: 28749949 [PubMed – indexed for MEDLINE]

Troudt J, Creissen E, Izzo L, Bielefeldt-Ohmann H, Casonato S, Manganelli R, Izzo AA. Mycobacterium tuberculosis sigE mutant ST28 used as a vaccine induces protective immunity in the guinea pig model. Tuberculosis (Edinb). 2017 Sep;106:99-105. doi: 10.1016/j.tube.2017.07.009. Epub 2017 Jul 24. PMID: 28802412 [PubMed – in process]

Izzo AA. Tuberculosis vaccines – perspectives from the NIH/NIAID Mycobacteria vaccine testing program. Curr Opin Immunol. 2017 Aug;47:78-84. doi: 10.1016/j.coi.2017.07.008. Epub 2017 Jul 24. Review. PMID: 28750280 [PubMed – indexed for MEDLINE]

Ramos L, Obregon-Henao A, Henao-Tamayo M, Bowen R, Lunney JK, Gonzalez-Juarrero M. The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission. Tuberculosis (Edinb). 2017 Sep;106:91-98. doi: 10.1016/j.tube.2017.07.003. Epub 2017 Jul 14. PMID: 28802411 [PubMed – in process]

De Groote MA, Sterling DG, Hraha T, Russell TM, Green LS, Wall K, Kraemer S, Ostroff R, Janjic N, Ochsner UA. Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis. J Clin Microbiol. 2017 Oct;55(10):3057-3071. doi: 10.1128/JCM.00467-17. Epub 2017 Aug 9. PMID: 28794177 [PubMed – in process]

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R. Correction for De Groote et al., “Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection”. J Clin Microbiol. 2017 May;55(5):1598. doi: 10.1128/JCM.00333-17. No abstract available.  PMID: 28442616 [PubMed]

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R. Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection. J Clin Microbiol. 2017 Feb;55(2):391-402. doi: 10.1128/JCM.01646-16. Epub 2016 Nov 16. Erratum in: J Clin Microbiol. 2017 May;55(5):1598. PMID: 27852671 [PubMed – indexed for MEDLINE]

Goehring LS, Brandes K, Ashton LV, Wittenburg LA, Olea-Popelka FJ, Lunn DP, Soboll Hussey G. Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro. Equine Vet J. 2017 Sep;49(5):629-636. doi: 10.1111/evj.12656. Epub 2017 Jan 17. PMID: 27864898 [PubMed – indexed for MEDLINE]

Higgins JL, Gonzalez-Juarrero M, Bowen RA. Evaluation of shedding, tissue burdens, and humoral immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence vaccine strain Rev. 1. PLoS One. 2017 Oct 13;12(10):e0185823. doi: 10.1371/journal.pone.0185823. eCollection 2017. PMID: 29028813 [PubMed – indexed for MEDLINE]

King TH, Shanley CA, Guo Z, Bellgrau D, Rodell T, Furney S, Henao-Tamayo M, Orme IM. GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis. Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00245-17. doi: 10.1128/CVI.00245-17. Print 2017 Dec. PMID: 29046306 [PubMed – in process]

Köster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby SJ, Mittal E, Park HS, Jones V, Hsu FF, Jackson M, Sassetti CM, Philips JA. <i>Mycobacterium tuberculosis</i> is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8711-E8720. doi: 10.1073/pnas.1707792114. Epub 2017 Sep 27. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 30;:. PMID: 28973896 [PubMed – in process]

Bernardes F Filho, Paula NA, Leite MN, Abi-Rached TLC, Vernal S, Silva MBD, Barreto JG, Spencer JS, Frade MAC. Evidence of hidden leprosy in a supposedly low endemic area of Brazil. Mem Inst Oswaldo Cruz. 2017 Dec;112(12):822-828. doi: 10.1590/0074-02760170173. PMID: 29211243 [PubMed – indexed for MEDLINE]

Wheat WH, Arthun EN, Spencer JS, Regan DP, Titus RG, Dow SW. Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model. Vaccine. 2017 Dec 4;35(48 Pt B):6611-6619. doi: 10.1016/j.vaccine.2017.10.039. Epub 2017 Oct 24. PMID: 29079105 [PubMed – in process]


Albesa-Jové D, Svetlíková Z, Tersa M, Sancho-Vaello E, Carreras-González A, Bonnet P, Arrasate P, Eguskiza A, Angala SK, Cifuente JO, Korduláková J, Jackson M, Mikušová K, Guerin ME. Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. Nat Commun. 2016 Mar 11;7:10906. doi: 10.1038/ncomms10906. PubMed PMID: 26965057; PubMed Central PMCID: PMC4792965.

Angala SK, McNeil MR, Zou L, Liav A, Zhang J, Lowary TL, Jackson M. Identification of a Novel Mycobacterial Arabinosyltransferase Activity Which Adds an Arabinosyl Residue to α-d-Mannosyl Residues. ACS Chem Biol. 2016 Jun 17;11(6):1518-24. doi: 10.1021/acschembio.6b00093. PubMed PMID: 27045860; PubMed Central PMCID: PMC4912395.

Bartek IL, Reichlen MJ, Honaker RW, Leistikow RL, Clambey ET, Scobey MS, Hinds AB, Born SE, Covey CR, Schurr MJ, Lenaerts AJ, Voskuil MI. Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis. mSphere. 2016 Aug 24;1(4). pii: e00176-16. doi: 10.1128/mSphere.00176-16. PubMed PMID: 27579369; PubMed Central PMCID: PMC4999920.

Belardinelli JM, Yazidi A, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J, Jackson M. Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis. ACS Infect Dis. 2016 Oct 14;2(10):702-713. PubMed PMID: 27737557; PubMed Central PMCID: PMC5117480.

Beltrán-Alzate C, López Díaz F, Romero-Montoya M, Sakamuri R, Li W, Kimura M, Brennan P, Cardona-Castro N. Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country. PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005041. doi: 10.1371/journal.pntd.0005041. PubMed PMID: 27706165; PubMed Central PMCID: PMC5051701.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ. Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity. J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. PubMed PMID: 27187871; PubMed Central PMCID: PMC4917603.

Brennan PJ. Bacterial evolution: Emergence of virulence in TB. Nat Microbiol. 2016 Jan 27;1:15031. doi: 10.1038/nmicrobiol.2015.31. PubMed PMID: 27571983.

Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler IC, Chapman SJ, Clayton A, Cullen M, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Daniels T, Humphrey H, Isalska B, Jensen-Fangel S, Jönsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O’Brien C, O’Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Floto RA. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science. 2016 Nov 11;354(6313):751-757. PubMed PMID: 27846606; PubMed Central PMCID: PMC5142603.

Crawford AC, Laurentius LB, Mulvihill TS, Granger JH, Spencer JS, Chatterjee D, Hanson KE, Porter MD. Detection of the tuberculosis antigenic marker mannose-capped lipoarabinomannan in pretreated serum by surface-enhanced Raman scattering. Analyst. 2016 Dec 19;142(1):186-196. PubMed PMID: 27924983.

Datta G, Nieto LM, Davidson RM, Mehaffy C, Pederson C, Dobos KM, Strong M. Longitudinal whole genome analysis of pre and post drug treatment Mycobacterium tuberculosis isolates reveals progressive steps to drug resistance. Tuberculosis (Edinb). 2016 May;98:50-5. doi: 10.1016/j.tube.2016.02.004. PubMed PMID: 27156618.

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R. Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection. J Clin Microbiol. 2017 Feb;55(2):391-402. doi: 10.1128/JCM.01646-16. PubMed PMID: 27852671.

Diaz G, Wolfe LM, Kruh-Garcia NA, Dobos KM. Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection. Sci Rep. 2016 Nov 29;6:37975. doi: 10.1038/srep37975. PubMed PMID: 27897233; PubMed Central PMCID: PMC5126699.

Drolet BS, Reister-Hendricks LM, Podell BK, Breitenbach JE, McVey DS, van Rijn PA, Bowen RA. European Bluetongue Serotype 8: Disease Threat Assessment for U.S. Sheep. Vector Borne Zoonotic Dis. 2016 Jun;16(6):400-7. doi: 10.1089/vbz.2015.1924. PubMed PMID: 27111674.

Foster CL, Badlam J, De Groote MA, Chan ED. A 65-Year-Old Groundskeeper With High Fever, Pulmonary Nodules, and Thoracic Lymphadenopathy. Chest. 2016 Jun;149(6):e191-4. doi: 10.1016/j.chest.2015.12.035. PubMed PMID: 27287596.

Fujiwara PI, Olea-Popelka F. Editorial Commentary: Why It Is Important to Distinguish Mycobacterium bovis as a Causal Agent of Human Tuberculosis. Clin Infect Dis. 2016 Sep 1;63(5):602-3. doi: 10.1093/cid/ciw374. PubMed PMID: 27298331.

Goehring LS, Brandes K, Ashton LV, Wittenburg LA, Olea-Popelka FJ, Lunn DP, Soboll Hussey G. Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro. Equine Vet J. 2016 Nov 19. doi: 10.1111/evj.12656. [Epub ahead of print] PubMed PMID: 27864898.

Grover A, McLean JL, Troudt JM, Foster C, Izzo L, Creissen E, MacDonald E, Troy A, Izzo AA. Heat killed Saccharomyces cerevisiae as an adjuvant for the induction of vaccine-mediated immunity against infection with Mycobacterium tuberculosis. Vaccine. 2016 May 27;34(25):2798-805. doi: 10.1016/j.vaccine.2016.04.052. PubMed PMID: 27131285.

Grzegorzewicz AE, de Sousa-d’Auria C, McNeil MR, Huc-Claustre E, Jones V, Petit C, Angala SK, Zemanová J, Wang Q, Belardinelli JM, Gao Q, Ishizaki Y, Mikušová K, Brennan PJ, Ronning DR, Chami M, Houssin C, Jackson M. Assembling of the Mycobacterium tuberculosis Cell Wall Core. J Biol Chem. 2016 Sep 2;291(36):18867-79. doi: 10.1074/jbc.M116.739227. PubMed PMID: 27417139; PubMed Central PMCID: PMC5009262.

Hemphill DD, McIlwraith CW, Slayden RA, Samulski RJ, Goodrich LR. Adeno-associated virus gene therapy vector scAAVIGF-I for transduction of equine articular chondrocytes and RNA-seq analysis. Osteoarthritis Cartilage. 2016 May;24(5):902-11. doi: 10.1016/j.joca.2015.12.001. PubMed PMID: 26706703.

Henao-Tamayo MI, Obregón-Henao A, Arnett K, Shanley CA, Podell B, Orme IM, Ordway DJ. Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection. J Leukoc Biol. 2016 Apr;99(4):605-17. doi: 10.1189/jlb.4A0614-308RR. PubMed PMID: 26590147; PubMed Central PMCID: PMC4787291.

Irwin SM, Prideaux B, Lyon ER, Zimmerman MD, Brooks EJ, Schrupp CA, Chen C, Reichlen MJ, Asay BC, Voskuil MI, Nuermberger EL, Andries K, Lyons MA, Dartois V, Lenaerts AJ. Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice. ACS Infect Dis. 2016 Apr 8;2(4):251-267. PubMed PMID: 27227164; PubMed Central PMCID: PMC4874602.

Kiran D, Podell BK, Chambers M, Basaraba RJ. Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review. Semin Immunopathol. 2016 Mar;38(2):167-83. doi: 10.1007/s00281-015-0537-x. Review. PubMed PMID: 26510950; PubMed Central PMCID: PMC4779125.

Knudson SE, Cummings JE, Bommineni GR, Pan P, Tonge PJ, Slayden RA. Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis. Tuberculosis (Edinb). 2016 Dec;101:8-14. doi: 10.1016/j.tube.2016.07.016. PubMed PMID: 27865404; PubMed Central PMCID: PMC5117134.

Kochen MA, Chambers MC, Holman JD, Nesvizhskii AI, Weintraub ST, Belisle JT, Islam MN, Griss J, Tabb DL. Greazy: Open-Source Software for Automated Phospholipid Tandem Mass Spectrometry Identification. Anal Chem. 2016 Jun 7;88(11):5733-41. doi: 10.1021/acs.analchem.6b00021. PubMed PMID: 27186799; PubMed Central PMCID: PMC4996967.

Laurentius LB, Crawford AC, Mulvihill TS, Granger JH, Robinson R, Spencer JS, Chatterjee D, Hanson KE, Porter MD. Importance of specimen pretreatment for the low-level detection of mycobacterial lipoarabinomannan in human serum. Analyst. 2016 Dec 19;142(1):177-185. PubMed PMID: 27934985.

Li W, Obregón-Henao A, Wallach JB, North EJ, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M. Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5198-207. doi: 10.1128/AAC.00826-16. PubMed PMID: 27297488; PubMed Central PMCID: PMC4997843.

Linke LM, Wilusz J, Pabilonia KL, Fruehauf J, Magnuson R, Olea-Popelka F, Triantis J, Landolt G, Salman M. Inhibiting avian influenza virus shedding using a novel RNAi antiviral vector technology: proof of concept in an avian cell model. AMB Express. 2016 Mar;6(1):16. doi: 10.1186/s13568-016-0187-y. PubMed PMID: 26910902; PubMed Central PMCID: PMC4766140.

Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE. Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. PubMed PMID: 28081607.

Man DK, Chow MY, Casettari L, Gonzalez-Juarrero M, Lam JK. Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis. Adv Drug Deliv Rev. 2016 Jul 1;102:21-32. doi: 10.1016/j.addr.2016.04.013. Review. PubMed PMID: 27108702.

McLean JL, Suchman EL. Using Magnets and Classroom Flipping to Promote Student Engagement and Learning about Protein Translation in a Large Microbiology Class. J Microbiol Biol Educ. 2016 May 4;17(2):288-9. doi: 10.1128/jmbe.v17i2.1048. PubMed PMID: 27158313; PubMed Central PMCID: PMC4858368.

McLean JL, Suchman EL. Video Lecture Capture Technology Helps Students Study without Affecting Attendance in Large Microbiology Lecture Courses. J Microbiol Biol Educ. 2016 Dec 2;17(3):480-481. doi: 10.1128/jmbe.v17i3.1123. PubMed PMID: 28101280; PubMed Central PMCID: PMC5134957.


Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Amara RR, Plikaytis BB, Posey JE, Sable SB. Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis. Sci Rep. 2016 May 13;6:25837. doi: 10.1038/srep25837. PubMed PMID: 27173443; PubMed Central PMCID: PMC4865829.

Nieto R LM, Mehaffy C, Creissen E, Troudt J, Troy A, Bielefeldt-Ohmann H, Burgos M, Izzo A, Dobos KM. Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC. PLoS One. 2016 Nov 28;11(11):e0166807. doi: 10.1371/journal.pone.0166807. PubMed PMID: 27893795; PubMed Central PMCID: PMC5125630.

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Kruh JN, Kruh-Garcia NA, Foster CS. Evaluation of the Effect of N-Acetylcysteine on Protein Deposition on Contact Lenses in Patients with the Boston Keratoprosthesis Type I. J Ocul Pharmacol Ther. 2015 Jul-Aug;31(6):314-22. doi: 10.1089/jop.2015.0010. PubMed PMID: 26133055.

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Orme IM, Robinson RT, Cooper AM. The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol. 2015 Jan;16(1):57-63. doi: 10.1038/ni.3048. Review. PubMed PMID: 25521685.

Passamonti F, Vardi DM, Stefanetti V, Marenzoni ML, Prato S, Cévese P, Coletti M, Pepe M, Casagrande Proietti P, Olea-Popelka F. Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice. Vet J. 2015 Feb;203(2):211-8. doi: 10.1016/j.tvjl.2014.08.033. PubMed PMID: 25555337.

Randall LB, Dobos K, Papp-Wallace KM, Bonomo RA, Schweizer HP. Membrane-Bound PenA β-Lactamase of Burkholderia pseudomallei. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1509-14. doi: 10.1128/AAC.02444-15. PubMed PMID: 26711764; PubMed Central PMCID: PMC4775993.

Richardson MA, Furlani RE, Podell BK, Ackart DF, Haugen JD, Melander RJ, Melander C, Basaraba RJ. Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. Tetrahedron Lett. 2015;56(23):3406-3409. PubMed PMID: 26146419; PubMed Central PMCID: PMC4487526.

Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC. Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ. ACS Cent Sci. 2015 Sep 23;1(6):292-302. PubMed PMID: 26436137; PubMed Central PMCID: PMC4582327.

Via LE, Savic R, Weiner DM, Zimmerman MD, Prideaux B, Irwin SM, Lyon E, O’Brien P, Gopal P, Eum S, Lee M, Lanoix JP, Dutta NK, Shim T, Cho JS, Kim W, Karakousis PC, Lenaerts A, Nuermberger E, Barry CE 3rd, Dartois V. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives. ACS Infect Dis. 2015 May 8;1(5):203-214. PubMed PMID: 26086040; PubMed Central PMCID: PMC4467917.

Wang Q, Zhu L, Jones V, Wang C, Hua Y, Shi X, Feng X, Jackson M, Niu C, Gao Q. CpsA, a LytR-CpsA-Psr Family Protein in Mycobacterium marinum, Is Required for Cell Wall Integrity and Virulence. Infect Immun. 2015 Jul;83(7):2844-54. doi: 10.1128/IAI.03081-14. PubMed PMID: 25939506; PubMed Central PMCID: PMC4468561.

Wheat WH, Dhouib R, Angala SK, Larrouy-Maumus G, Dobos K, Nigou J, Spencer JS, Jackson M. The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10. Tuberculosis (Edinb). 2015 Jul;95(4):476-89. doi: 10.1016/j.tube.2015.04.002. PubMed PMID: 26048627; PubMed Central PMCID: PMC4475442.

Williams MJ, Shanley CA, Zilavy A, Peixoto B, Manca C, Kaplan G, Orme IM, Mizrahi V, Kana BD. bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs. Infect Immun. 2015 Feb;83(2):544-50. doi: 10.1128/IAI.02722-14. PubMed PMID: 25404027; PubMed Central PMCID: PMC4294236.

Yu CH, Micaroni M, Puyskens A, Schultz TE, Yeo JC, Stanley AC, Lucas M, Kurihara J, Dobos KM, Stow JL, Blumenthal A. RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection. J Immunol. 2015 Oct 15;195(8):3890-900. doi: 10.4049/jimmunol.1500017. PubMed PMID: 26371254.

Ackart DF, Hascall-Dove L, Caceres SM, Kirk NM, Podell BK, Melander C, Orme IM, Leid JG, Nick JA, Basaraba RJ. Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. Pathog Dis. 2014 Apr;70(3):359-69. doi: 10.1111/2049-632X.12144. Epub 2014 Feb 24. PubMed PMID: 24478060.

Ackart DF, Lindsey EA, Podell BK, Melander RJ, Basaraba RJ, Melander C. Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules. Pathog Dis. 2014 Apr;70(3):370-8. doi: 10.1111/2049-632X.12143. Epub 2014 Feb 24. PubMed PMID: 24478046.

Adams AE, Olea-Popelka FJ, Grandin T, Woerner DR, Roman-Muniz IN. Dairy cow handling facilities and the perception of Beef Quality Assurance on Colorado dairies. J Dairy Sci. 2014 Feb;97(2):798-804. doi: 10.3168/jds.2013-7146. Epub 2013 Dec 15. PubMed PMID: 24342695.

Aiyaz M, Bipin C, Pantulwar V, Mugasimangalam R, Shanley CA, Ordway DJ, Orme IM. Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372. Tuberculosis (Edinb). 2014 Oct 13. pii: S1472-9792(14)20491-4. doi: 10.1016/j.tube.2014.10.001. [Epub ahead of print] PubMed PMID: 25423882.

Aiyaz M, Bipin C, Pantulwar V, Mugasimangalam R, Shanley CA, Ordway DJ, Orme IM. Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372. Tuberculosis (Edinb). 2014 Dec;94(6):606-15. PubMed PMID: 25621360.

Angala SK, Belardinelli JM, Huc-Claustre E, Wheat WH, Jackson M. The cell envelope glycoconjugates of Mycobacterium tuberculosis. Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):361-99. doi: 10.3109/10409238.2014.925420. Epub 2014 Jun 10. PubMed PMID: 24915502.

Barreto JG, Bisanzio D, Guimarães Lde S, Spencer JS, Vazquez-Prokopec GM, Kitron U, Salgado CG. Spatial analysis spotlighting early childhood leprosy transmission in a hyperendemic municipality of the Brazilian Amazon region. PLoS Negl Trop Dis. 2014 Feb 6;8(2):e2665. doi: 10.1371/journal.pntd.0002665. eCollection 2014 Feb. PubMed PMID: 24516679; PubMed Central PMCID: PMC3916250.

Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI. Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence. MBio. 2014 Jun 3;5(3):e01106-14. doi: 10.1128/mBio.01106-14. PubMed PMID: 24895305; PubMed Central PMCID: PMC4049101.

Belardinelli JM, Larrouy-Maumus G, Jones V, Sorio de Carvalho LP, McNeil MR, Jackson M. Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis. J Biol Chem. 2014 Oct 3;289(40):27952-65. doi: 10.1074/jbc.M114.581199. Epub 2014 Aug 14. PubMed PMID: 25124040; PubMed Central PMCID: PMC4183827.

Bobosha K, Tjon Kon Fat EM, van den Eeden SJ, Bekele Y, van der Ploeg-van Schip JJ, de Dood CJ, Dijkman K, Franken KL, Wilson L, Aseffa A, Spencer JS, Ottenhoff TH, Corstjens PL, Geluk A. Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. PLoS Negl Trop Dis. 2014 May 8;8(5):e2845. doi: 10.1371/journal.pntd.0002845. eCollection 2014 May. PubMed PMID: 24810599; PubMed Central PMCID: PMC4014418.

Calado Nogueira de Moura V, Gibbs S, Jackson M. Gene replacement in Mycobacterium chelonae: application to the construction of porin knock-out mutants. PLoS One. 2014 Apr 16;9(4):e94951. doi: 10.1371/journal.pone.0094951. eCollection 2014. PubMed PMID: 24739882; PubMed Central PMCID: PMC3989263.

Capodagli GC, Sedhom WG, Jackson M, Ahrendt KA, Pegan SD. A noncompetitive inhibitor for Mycobacterium tuberculosis’s class IIa fructose 1,6-bisphosphate aldolase. Biochemistry. 2014 Jan 14;53(1):202-13. doi: 10.1021/bi401022b. Epub 2013 Dec 24. PubMed PMID: 24325645; PubMed Central PMCID: PMC4167715.

Chan ED, Kinney WH, Honda JR, Bishwakarma R, Gangavelli A, Mya J, Bai X, Ordway DJ. Tobacco exposure and susceptibility to tuberculosis: is there a smoking gun? Tuberculosis (Edinb). 2014 Dec;94(6):544-50. doi: 10.1016/j.tube.2014.08.010. Epub 2014 Sep 28. PubMed PMID: 25305002.

Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, Guo RT. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J Am Chem Soc. 2014 Feb 19;136(7):2892-6. doi: 10.1021/ja413127v. Epub 2014 Feb 5. PubMed PMID: 24475925; PubMed Central PMCID: PMC3986019.

Correa AF, Bailão AM, Bastos IM, Orme IM, Soares CM, Kipnis A, Santana JM, Junqueira-Kipnis AP. The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection. Infect Immun. 2014 Dec;82(12):5154-65. doi: 10.1128/IAI.02304-14. Epub 2014 Sep 29. PubMed PMID: 25267836; PubMed Central PMCID: PMC4249283.

Daffé M, Crick DC, Jackson M. Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids. Microbiol Spectr. 2014;2(4). pii: 14. PubMed PMID: 25485178; PubMed Central PMCID: PMC4255156.

De Groote MA, Gibbs S, de Moura VC, Burgess W, Richardson K, Kasperbauer S, Madinger N, Jackson M. Analysis of a panel of rapidly growing mycobacteria for resistance to aldehyde-based disinfectants. Am J Infect Control. 2014 Aug;42(8):932-4. doi: 10.1016/j.ajic.2014.05.014. PubMed PMID: 25087149; PubMed Central PMCID: PMC4121594.

De Groote MA, Johnson L, Podell B, Brooks E, Basaraba R, Gonzalez-Juarrero M. GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus. J Antimicrob Chemother. 2014 Apr;69(4):1057-64. doi: 10.1093/jac/dkt451. Epub 2013 Nov 11. PubMed PMID: 24222613.

Esparza-Gonzalez SC, Troy AR, Izzo AA. Comparative analysis of Bacillus subtilis spores and monophosphoryl lipid A as adjuvants of protein-based mycobacterium tuberculosis-based vaccines: partial requirement for interleukin-17a for induction of protective immunity. Clin Vaccine Immunol. 2014 Apr;21(4):501-8. doi: 10.1128/CVI.00622-13. Epub 2014 Jan 29. PubMed PMID: 24477855; PubMed Central PMCID: PMC3993107.

Fletcher, D.M., M.B. Vogt, H.E. Pirner, A.M. Hess, R.A. Bowen, M. Henao-Tamayo, and T.M. Eckstein. 2013 Flow cytometry baseline on peripheral leukocyte cell profiles for dairy goat kids.  Am. J. Anim.  Vet. Sci. 8:177-189.

Forrellad MA, McNeil M, Santangelo Mde L, Blanco FC, García E, Klepp LI, Huff J, Niederweis M, Jackson M, Bigi F. Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2014 Mar;94(2):170-7. doi: 10.1016/j.tube.2013.12.005. Epub 2014 Jan 2. PubMed PMID: 24440549; PubMed Central PMCID: PMC3951760.

Grover A, Troudt J, Foster C, Basaraba R, Izzo A. High mobility group box 1 acts as an adjuvant for tuberculosis subunit vaccines. Immunology. 2014 May;142(1):111-23. doi: 10.1111/imm.12236. PubMed PMID: 24350616; PubMed Central PMCID: PMC3992053.

Hagge DA, Scollard DM, Ray NA, Marks VT, Deming AT, Spencer JS, Adams LB. IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy. PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3149. doi: 10.1371/journal.pntd.0003149. eCollection 2014 Sep. PubMed PMID: 25210773; PubMed Central PMCID: PMC4161319.

Henao-Tamayo M, Obregón-Henao A, Creissen E, Shanley C, Orme I, Ordway DJ. Differential Mycobacterium bovis BCG Vaccine-Derived Efficacy in C3Heb/FeJ and C3H/HeOuJ Mice Exposed to a Clinical Strain of Mycobacterium tuberculosis. Clin Vaccine Immunol. 2015 Jan;22(1):91-8. doi: 10.1128/CVI.00466-14. Epub 2014 Nov 12. PubMed PMID: 25392011; PubMed Central PMCID: PMC4278923.

Henao-Tamayo M, Ordway DJ, Orme IM. Memory T cell subsets in tuberculosis: what should we be targeting? Tuberculosis (Edinb). 2014 Sep;94(5):455-61. doi: 10.1016/j.tube.2014.05.001. Epub 2014 Jun 17. PubMed PMID: 24993316.

Humphrey HM, Orloski KA, Olea-Popelka FJ. Bovine tuberculosis slaughter surveillance in the United States 2001-2010: assessment of its traceback investigation function. BMC Vet Res. 2014 Aug 15;10(1):182. doi: 10.1186/s12917-014-0182-y. PubMed PMID: 25123050; PubMed Central PMCID: PMC4145249.

Irwin SM, Gruppo V, Brooks E, Gilliland J, Scherman M, Reichlen MJ, Leistikow R, Kramnik I, Nuermberger EL, Voskuil MI, Lenaerts AJ. Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas. Antimicrob Agents Chemother. 2014 Jul;58(7):4026-34. doi: 10.1128/AAC.02565-14. Epub 2014 May 5. PubMed PMID: 24798275; PubMed Central PMCID: PMC4068578.

Jackson M. The mycobacterial cell envelope-lipids. Cold Spring Harb Perspect Med. 2014 Aug 7;4(10). pii: a021105. doi: 10.1101/cshperspect.a021105. PubMed PMID: 25104772.

Kaur D, Angala SK, Wu SW, Khoo KH, Chatterjee D, Brennan PJ, Jackson M, McNeil MR. A single arabinan chain is attached to the phosphatidylinositol mannosyl core of the major immunomodulatory mycobacterial cell envelope glycoconjugate, lipoarabinomannan. J Biol Chem. 2014 Oct 31;289(44):30249-56. doi: 10.1074/jbc.M114.599415. Epub 2014 Sep 17. PubMed PMID: 25231986; PubMed Central PMCID: PMC4215209.

Kerns PW, Ackhart DF, Basaraba RJ, Leid JG, Shirtliff ME. Mycobacterium tuberculosis pellicles express unique proteins recognized by the host humoral response. Pathog Dis. 2014 Apr;70(3):347-58. doi: 10.1111/2049-632X.12142. Epub 2014 Feb 26. PubMed PMID: 24453174.

Kim HJ, Brennan PJ, Heaslip D, Udey MC, Modlin RL, Belisle JT. Carbohydrate-Dependent Binding of Langerin to SodC, a Cell Wall Glycoprotein of Mycobacterium leprae. J Bacteriol. 2015 Feb 1;197(3):615-25. doi: 10.1128/JB.02080-14. Epub 2014 Nov 24. PubMed PMID: 25422308.

Knudson SE, Kumar K, Awasthi D, Ojima I, Slayden RA. In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis. Tuberculosis (Edinb). 2014 May;94(3):271-6. doi: 10.1016/j.tube.2014.03.007. Epub 2014 Apr 1. PubMed PMID: 24746463; PubMed Central PMCID: PMC4068151.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA. A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis. PLoS One. 2014 Apr 15;9(4):e93953. doi: 10.1371/journal.pone.0093953. eCollection 2014. PubMed PMID: 24736743; PubMed Central PMCID: PMC3988029.

Kruh-Garcia NA, Wolfe LM, Dobos KM. Deciphering the role of exosomes in tuberculosis. Tuberculosis (Edinb). 2015 Jan;95(1):26-30. doi: 10.1016/j.tube.2014.10.010. Epub 2014 Nov 21. Review. PubMed PMID: 25496995.

Kruh-Garcia NA, Murray M, Prucha JG, Dobos KM. Antigen 85 variation across lineages of Mycobacterium tuberculosis-implications for vaccine and biomarker success. J Proteomics. 2014 Jan 31;97:141-50. doi: 10.1016/j.jprot.2013.07.005. Epub 2013 Jul 24. PubMed PMID: 23891556.

Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM. Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS. PLoS One. 2014 Jul 31;9(7):e103811. doi: 10.1371/journal.pone.0103811. eCollection 2014. PubMed PMID: 25080351; PubMed Central PMCID: PMC4117584.

Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ. Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nat Med. 2014 Feb;20(2):152-8. doi: 10.1038/nm.3458. Epub 2014 Jan 26. PubMed PMID: 24464186; PubMed Central PMCID: PMC3972818.

Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E. Multitarget drug discovery for tuberculosis and other infectious diseases. J Med Chem. 2014 Apr 10;57(7):3126-39. doi: 10.1021/jm500131s. Epub 2014 Apr 1. PubMed PMID: 24568559; PubMed Central PMCID: PMC4084622.

Li W, Upadhyay A, Fontes FL, North EJ, Wang Y, Crans DC, Grzegorzewicz AE, Jones V, Franzblau SG, Lee RE, Crick DC, Jackson M. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 Nov;58(11):6413-23. doi: 10.1128/AAC.03229-14. Epub 2014 Aug 18. PubMed PMID: 25136022; PubMed Central PMCID: PMC4249373.

Lishnevsky M, Young LC, Woods SJ, Groshong SD, Basaraba RJ, Gilchrist JM, Higgins DM, Gonzalez-Juarrero M, Bass TA, Muller WA, Schenkel AR. Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice. Exp Mol Pathol. 2014 Aug;97(1):128-36. doi: 10.1016/j.yexmp.2014.06.008. Epub 2014 Jun 24. PubMed PMID: 24972347.

Lyons MA. Computational pharmacology of rifampin in mice: an application to dose optimization with conflicting objectives in tuberculosis treatment. J Pharmacokinet Pharmacodyn. 2014 Dec;41(6):613-23. doi: 10.1007/s10928-014-9380-2. Epub 2014 Aug 31. PubMed PMID: 25173151.

Mahapatra S, Hess AM, Johnson JL, Eisenach KD, DeGroote MA, Gitta P, Joloba ML, Kaplan G, Walzl G, Boom WH, Belisle JT. A metabolic biosignature of early response to anti-tuberculosis treatment. BMC Infect Dis. 2014 Jan 31;14:53. doi: 10.1186/1471-2334-14-53. PubMed PMID: 24484441; PubMed Central PMCID: PMC3918231.

Meyer M, Freihofer P, Scherman M, Teague J, Lenaerts A, Böttger EC. In vivo efficacy of apramycin in murine infection models. Antimicrob Agents Chemother. 2014 Nov;58(11):6938-41. doi: 10.1128/AAC.03239-14. Epub 2014 Aug 18. PubMed PMID: 25136009; PubMed Central PMCID: PMC4249428.

North EJ, Jackson M, Lee RE. New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics. Curr Pharm Des. 2014;20(27):4357-78. PubMed PMID: 24245756.

Orme I. Letter to the editor. Tuberculosis (Edinb). 2014 Dec;94(6):717. doi: 10.1016/j.tube.2014.08.004. Epub 2014 Sep 19. PubMed PMID: 25293999.

Orme IM, Ordway DJ. Host response to nontuberculous mycobacterial infections of current clinical importance. Infect Immun. 2014 Sep;82(9):3516-22. doi: 10.1128/IAI.01606-13. Epub 2014 Jun 9. PubMed PMID: 24914222; PubMed Central PMCID: PMC4187800.

Orme IM, Basaraba RJ. The formation of the granuloma in tuberculosis infection. Semin Immunol. 2014 Oct 22;26(6):601-609. doi: 10.1016/j.smim.2014.09.009. [Epub ahead of print] Review. PubMed PMID: 25453231.

Orme IM. Vaccines to prevent tuberculosis infection rather than disease: Physiological and immunological aspects. Tuberculosis (Edinb). 2014 Nov 27. pii: S1472-9792(14)20550-6. doi: 10.1016/j.tube.2014.10.008. [Epub ahead of print] Review. PubMed PMID: 25500316.

Orme IM. A new unifying theory of the pathogenesis of tuberculosis. Tuberculosis (Edinb). 2014 Jan;94(1):8-14. doi: 10.1016/j.tube.2013.07.004. Epub 2013 Aug 4. PubMed PMID: 24157189; PubMed Central PMCID: PMC3877201.

Orme IM. Tuberculosis vaccines: types and timings. Clin Vaccine Immunol. 2014 Dec 24. pii: CVI.00718-14. [Epub ahead of print] PubMed PMID: 25540272.

Orme IM, Robinson RT, Cooper AM. The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol. 2014 Dec 18;16(1):57-63. doi: 10.1038/ni.3048. Review. PubMed PMID: 25521685.

Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy. ChemMedChem. 2014 Apr;9(4):776-91. doi: 10.1002/cmdc.201300429. Epub 2014 Mar 11. PubMed PMID: 24616444; PubMed Central PMCID: PMC4126670.

Park B, Awasthi D, Chowdhury SR, Melief EH, Kumar K, Knudson SE, Slayden RA, Ojima I. Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Bioorg Med Chem. 2014 May 1;22(9):2602-12. doi: 10.1016/j.bmc.2014.03.035. Epub 2014 Apr 1. PubMed PMID: 24726304; PubMed Central PMCID: PMC4045703.

Perley CC, Frahm M, Click EM, Dobos KM, Ferrari G, Stout JE, Frothingham R. The human antibody response to the surface of Mycobacterium tuberculosis. PLoS One. 2014 Jun 11;9(2):e98938. doi: 10.1371/journal.pone.0098938. eCollection 2014. PubMed PMID: 24918450; PubMed Central PMCID: PMC4053328.

Podell BK, Ackart DF, Obregon-Henao A, Eck SP, Henao-Tamayo M, Richardson M, Orme IM, Ordway DJ, Basaraba RJ. Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity. Am J Pathol. 2014 Apr;184(4):1104-18. doi: 10.1016/j.ajpath.2013.12.015. Epub 2014 Jan 31. PubMed PMID: 24492198; PubMed Central PMCID: PMC3969993.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog. 2014 May 22;10(5):e1004144. doi: 10.1371/journal.ppat.1004144. eCollection 2014 May. PubMed PMID: 24851864; PubMed Central PMCID: PMC4031216.

Rakesh, Bruhn DF, Scherman MS, Woolhiser LK, Madhura DB, Maddox MM, Singh AP, Lee RB, Hurdle JG, McNeil MR, Lenaerts AJ, Meibohm B, Lee RE. Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. PLoS One. 2014 Feb 5;9(2):e87909. doi: 10.1371/journal.pone.0087909. eCollection 2014. PubMed PMID: 24505329; PubMed Central PMCID: PMC3914891.

Rivoire BL, Groathouse NA, TerLouw S, Neupane KD, Ranjit C, Sapkota BR, Khadge S, Kunwar CB, Macdonald M, Hawksworth R, Thapa MB, Hagge DA, Tibbals M, Smith C, Dube T, She D, Wolff M, Zhou E, Makhene M, Mason R, Sizemore C, Brennan PJ. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study. PLoS Negl Trop Dis. 2014 May 29;8(5):e2811. doi: 10.1371/journal.pntd.0002811. eCollection 2014. PubMed PMID: 24874401; PubMed Central PMCID: PMC4038488.

Rivoire BL, TerLouw S, Groathouse NA, Brennan PJ. The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy. PLoS Negl Trop Dis. 2014 May 29;8(5):e2791. doi: 10.1371/journal.pntd.0002791. eCollection 2014. PubMed PMID: 24874086; PubMed Central PMCID: PMC4038479.

Ryan GJ, Shapiro HM, Lenaerts AJ. Improving acid-fast fluorescent staining for the detection of mycobacteria using a new nucleic acid staining approach. Tuberculosis (Edinb). 2014 Sep;94(5):511-8. doi: 10.1016/j.tube.2014.07.004. Epub 2014 Jul 28. PubMed PMID: 25130623.

Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, Sotriffer CA, Tonge PJ, Kisker C. Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. J Biol Chem. 2014 Jun 6;289(23):15987-6005. doi: 10.1074/jbc.M113.532804. Epub 2014 Apr 16. PubMed PMID: 24739388; PubMed Central PMCID: PMC4047375.

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Yang L, Lu S, Belardinelli J, Huc-Claustre E, Jones V, Jackson M, Zgurskaya HI. RND transporters protect Corynebacterium glutamicum from antibiotics by assembling the outer membrane. Microbiologyopen. 2014 Aug;3(4):484-96. doi: 10.1002/mbo3.182. Epub 2014 Jun 18. PubMed PMID: 24942069; PubMed Central PMCID:  PMC4287177.

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Awasthi D, Kumar K, Knudson SE, Slayden RA, Ojima I. SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents. J Med Chem. 2013 Dec 12;56(23):9756-70. doi: 10.1021/jm401468w. Epub 2013 Nov 23. PubMed PMID: 24266862; PubMed Central PMCID: PMC3933301.

Bai X, Feldman NE, Chmura K, Ovrutsky AR, Su WL, Griffin L, Pyeon D, McGibney  MT, Strand MJ, Numata M, Murakami S, Gaido L, Honda JR, Kinney WH, Oberley-Deegan RE, Voelker DR, Ordway DJ, Chan ED. Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages. PLoS One. 2013 Apr 25;8(4):e61925. doi: 10.1371/journal.pone.0061925. Print 2013. PubMed PMID: 23634218; PubMed Central PMCID: PMC3636238.

Beam AL, Thilmany DD, Garber LP, Van Metre DC, Pritchard RW, Kopral CA, Olea-Popelka FJ. Factors affecting use of veterinarians by small-scale food animal operations. J Am Vet Med Assoc. 2013 Nov 1;243(9):1334-44. doi: 10.2460/javma.243.9.1334. PubMed PMID: 24134586.

Booysen LL, Kalombo L, Brooks E, Hansen R, Gilliland J, Gruppo V, Lungenhofer P, Semete-Makokotlela B, Swai HS, Kotze AF, Lenaerts A, du Plessis LH. In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid. Int J Pharm. 2013 Feb 28;444(1-2):10-7. doi: 10.1016/j.ijpharm.2013.01.038. Epub 2013 Jan 26. PubMed PMID: 23357255.

Brennan PJ, Brosch R, Birren B, Sobral B. TBCAP; tuberculosis annotation project. Tuberculosis (Edinb). 2013 Jan;93(1):1-5. doi: 10.1016/j.tube.2012.11.013. Epub 2013 Jan 16. PubMed PMID: 23332402.

Cardona-Castro N, Beltrán-Alzate JC, Romero-Montoya IM, Li W, Brennan PJ, Vissa V. Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography. Infect Genet Evol. 2013 Mar;14:375-82. doi: 10.1016/j.meegid.2012.12.015. Epub 2013 Jan 3. PubMed PMID: 23291420; PubMed Central PMCID: PMC3668693.

Cayabyab MJ, Qin L, Kashino SS, Izzo A, Campos-Neto A. An unbiased peptide-wide discovery approach to select Mycobacterium tuberculosis antigens that target CD8+ T cell response during infection. Vaccine. 2013 Oct 1;31(42):4834-40. doi: 10.1016/j.vaccine.2013.07.077. Epub 2013 Aug 9. PubMed PMID: 23933335; PubMed Central PMCID: PMC3778375.

Cui P, Vissa V, Li W, Zhang X, Lin L, Wang H, Liu X, Wu Q, Zong W. Cutaneous  Mycobacterium shigaense infection in immunocompetent Woman, China. Emerg Infect Dis. 2013 May;19(5):819-20. doi: 10.3201/eid1905.121022. PubMed PMID: 23697461; PubMed Central PMCID: PMC3647498.

Davidson RM, Hasan NA, de Moura VC, Duarte RS, Jackson M, Strong M. Phylogenomics of Brazilian epidemic isolates of Mycobacterium abscessus subsp. bolletii reveals relationships of global outbreak strains. Infect Genet Evol. 2013 Dec;20:292-7. doi: 10.1016/j.meegid.2013.09.012. Epub 2013 Sep 18. PubMed PMID: 24055961; PubMed Central PMCID: PMC3853122.

Davidson RM, Reynolds PR, Farias-Hesson E, Duarte RS, Jackson M, Strong M. Genome Sequence of an Epidemic Isolate of Mycobacterium abscessus subsp. Bolletii from Rio de Janeiro, Brazil. Genome Announc. 2013 Aug 15;1(4). pii: e00617-13. doi: 10.1128/genomeA.00617-13. PubMed PMID: 23950125; PubMed Central PMCID: PMC3744681.

de Léséleuc L, Orlova M, Cobat A, Girard M, Huong NT, Ba NN, Thuc NV, Truman R, Spencer JS, Adams L, Thai VH, Alcais A, Schurr E. PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages. PLoS Negl Trop Dis. 2013;7(1):e2015. doi: 10.1371/journal.pntd.0002015. Epub 2013 Jan 17. PubMed PMID: 23350010; PubMed Central PMCID: PMC3547867.

Deshayes C, Angala SK, Marion E, Brandli I, Babonneau J, Preisser L, Eyangoh  S, Delneste Y, Legras P, De Chastellier C, Stinear TP, Jackson M, Marsollier L. Regulation of mycolactone, the Mycobacterium ulcerans toxin, depends on nutrient source. PLoS Negl Trop Dis. 2013 Nov 14;7(11):e2502. doi: 10.1371/journal.pntd.0002502. eCollection 2013 Nov. PubMed PMID: 24244764; PubMed Central PMCID: PMC3828164.

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Ekins S, Reynolds RC, Kim H, Koo MS, Ekonomidis M, Talaue M, Paget SD, Woolhiser LK, Lenaerts AJ, Bunin BA, Connell N, Freundlich JS. Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery. Chem Biol. 2013 Mar 21;20(3):370-8. doi: 10.1016/j.chembiol.2013.01.011. PubMed PMID:  23521795; PubMed Central PMCID: PMC3607962.

Favrot L, Grzegorzewicz AE, Lajiness DH, Marvin RK, Boucau J, Isailovic D, Jackson M, Ronning DR. Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun. 2013;4:2748. doi: 10.1038/ncomms3748. PubMed PMID: 24193546; PubMed Central PMCID: PMC4049535.

Gonzalez-Juarrero M, Bosco-Lauth A, Podell B, Soffler C, Brooks E, Izzo A, Sanchez-Campillo J, Bowen R. Experimental aerosol Mycobacterium bovis model of infection in goats. Tuberculosis (Edinb). 2013 Sep;93(5):558-64. doi: 10.1016/j.tube.2013.05.006. Epub 2013 Jul 10. PubMed PMID: 23850102.

Gonzalez-Juarrero M, Mima N, Trunck LA, Schweizer HP, Bowen RA, Dascher K, Mwangi W, Eckstein TM. Polar lipids of Burkholderia pseudomallei induce different host immune responses. PLoS One. 2013 Nov 18;8(11):e80368. doi: 10.1371/journal.pone.0080368. eCollection 2013. PubMed PMID: 24260378; PubMed Central PMCID: PMC3832426.

Grzegorzewicz AE, Jackson M. Subfractionation and analysis of the cell envelope (lipo)polysaccharides of Mycobacterium tuberculosis. Methods Mol Biol. 2013;966:309-24. doi: 10.1007/978-1-62703-245-2_19. PubMed PMID: 23299743; PubMed Central PMCID: PMC4041545.

Ishizaki Y, Hayashi C, Inoue K, Igarashi M, Takahashi Y, Pujari V, Crick DC,  Brennan PJ, Nomoto A. Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45. J Biol Chem. 2013 Oct 18;288(42):30309-19. doi: 10.1074/jbc.M113.492173. Epub 2013 Aug 28. PubMed PMID: 23986448; PubMed Central PMCID: PMC3798496.

Jackson M, McNeil MR, Brennan PJ. Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis. Future Microbiol. 2013 Jul;8(7):855-75. doi: 10.2217/fmb.13.52. Review. PubMed PMID: 23841633; PubMed Central PMCID: PMC3867987.

Kim HJ, Prithiviraj K, Groathouse N, Brennan PJ, Spencer JS. Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR. Clin Vaccine Immunol. 2013 Feb;20(2):181-90. doi: 10.1128/CVI.00419-12. Epub 2012 Dec 12. PubMed PMID:  23239802; PubMed Central PMCID: PMC3571279.

Liu CF, Tonini L, Malaga W, Beau M, Stella A, Bouyssié D, Jackson MC, Nigou J, Puzo G, Guilhot C, Burlet-Schiltz O, Rivière M. Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6560-5. doi: 10.1073/pnas.1219704110. Epub 2013 Apr 2. PubMed PMID: 23550160; PubMed Central PMCID: PMC3631654.

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Mahapatra S, Piechota C, Gil F, Ma Y, Huang H, Scherman MS, Jones V, Pavelka MS Jr, Moniz-Pereira J, Pimentel M, McNeil MR, Crick DC. Mycobacteriophage Ms6 LysA: a peptidoglycan amidase and a useful analytical tool. Appl Environ Microbiol. 2013 Feb;79(3):768-73. doi: 10.1128/AEM.02263-12. Epub 2012 Nov 16. PubMed PMID: 23160121; PubMed Central PMCID: PMC3568546.

Malone AN, Fletcher DM, Vogt MB, Meyer SK, Hess AM, Eckstein TM. Early weight development of goats experimentally infected with Mycobacterium avium subsp. paratuberculosis. PLoS One. 2013 Dec 11;8(12):e84049. doi: 10.1371/journal.pone.0084049. eCollection 2013. PubMed PMID: 24349564; PubMed Central PMCID: PMC3859668.

Miller M, Olea-Popelka F. One Health in the shrinking world: experiences with tuberculosis at the human-livestock-wildlife interface. Comp Immunol Microbiol Infect Dis. 2013 May;36(3):263-8. doi: 10.1016/j.cimid.2012.07.005. Epub 2012 Aug 22. Review. PubMed PMID: 22921281.

Miller M, Buss P, Joubert J, Mathebula N, Kruger M, Martin L, Hofmeyr M, Olea-Popelka F. Use of butorphanol during immobilization of free-ranging white rhinoceros (Ceratotherium simum). J Zoo Wildl Med. 2013 Mar;44(1):55-61. PubMed PMID: 23505703.

Muwonge A, Kankya C, Olea-Popelka F, Biffa D, Ssengooba W, Berit D, Skjerve E, Johansen TB. Molecular investigation of multiple strain infections in patients with tuberculosis in Mubende district, Uganda. Infect Genet Evol. 2013 Jul;17:16-22. doi: 10.1016/j.meegid.2013.03.039. Epub 2013 Mar 30. PubMed PMID: 23548804.

Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Fang S, McDonald  MA, Pohl J, Birkness K, Chamcha V, Ramirez MV, Plikaytis BB, Posey JE, Amara RR,  Sable SB. O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection. PLoS Pathog. 2013;9(10):e1003705. doi: 10.1371/journal.ppat.1003705.  Epub 2013 Oct 10. PubMed PMID: 24130497; PubMed Central PMCID: PMC3795050.

North EJ, Scherman MS, Bruhn DF, Scarborough JS, Maddox MM, Jones V, Grzegorzewicz A, Yang L, Hess T, Morisseau C, Jackson M, McNeil MR, Lee RE. Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorg Med Chem. 2013 May 1;21(9):2587-99. doi: 10.1016/j.bmc.2013.02.028. Epub 2013 Feb 26. PubMed PMID: 23498915; PubMed Central PMCID: PMC3780361.

O’Hara S, Wang K, Slayden RA, Schenkel AR, Huber G, O’Hern CS, Shattuck MD, Kirby M. Iterative feature removal yields highly discriminative pathways. BMC Genomics. 2013 Nov 25;14:832. doi: 10.1186/1471 2164-14-832. PubMed PMID: 24274115; PubMed Central PMCID: PMC3879090.

Obregón-Henao A, Henao-Tamayo M, Orme IM, Ordway DJ. Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection. PLoS One. 2013 Nov 1;8(11):e80669. doi: 10.1371/journal.pone.0080669. eCollection 2013. PubMed PMID: 24224058; PubMed Central PMCID: PMC3815237.

Orlova M, Cobat A, Huong NT, Ba NN, Van Thuc N, Spencer J, Nédélec Y, Barreiro L, Thai VH, Abel L, Alcaïs A, Schurr E. Gene set signature of reversal reaction type I in leprosy patients. PLoS Genet. 2013;9(7):e1003624. doi: 10.1371/journal.pgen.1003624. Epub 2013 Jul 11. PubMed PMID: 23874223; PubMed Central PMCID: PMC3708838.

Orme IM. Vaccine development for tuberculosis: current progress. Drugs. 2013  Jul;73(10):1015-24. doi: 10.1007/s40265-013-0081-8. Review. PubMed PMID: 23794129; PubMed Central PMCID: PMC3752905.

Ovrutsky AR, Chan ED, Kartalija M, Bai X, Jackson M, Gibbs S, Falkinham JO 3rd, Iseman MD, Reynolds PR, McDonnell G, Thomas V. Cooccurrence of free-living amoebae and nontuberculous Mycobacteria in hospital water networks, and preferential growth of Mycobacterium avium in Acanthamoeba lenticulata. Appl Environ Microbiol. 2013 May;79(10):3185-92. doi: 10.1128/AEM.03823-12. Epub 2013 Mar 8. PubMed PMID: 23475613; PubMed Central PMCID: PMC3685249.

Pethe K, Bifani P, Jang J, Kang S, Park S, Ahn S, Jiricek J, Jung J, Jeon HK, Cechetto J, Christophe T, Lee H, Kempf M, Jackson M, Lenaerts AJ, Pham H, Jones V, Seo MJ, Kim YM, Seo M, Seo JJ, Park D, Ko Y, Choi I, Kim R, Kim SY, Lim S, Yim SA, Nam J, Kang H, Kwon H, Oh CT, Cho Y, Jang Y, Kim J, Chua A, Tan BH, Nanjundappa MB, Rao SP, Barnes WS, Wintjens R, Walker JR, Alonso S, Lee S, Kim J, Oh S, Oh T, Nehrbass U, Han SJ, No Z, Lee J, Brodin P, Cho SN, Nam K, Kim J. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60. doi: 10.1038/nm.3262. Epub 2013 Aug 4. PubMed PMID: 23913123.

Ramirez MV, Dawson CC, Crew R, England K, Slayden RA. MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. BMC Microbiol. 2013 Oct 31;13:240. doi: 10.1186/1471-2180-13-240. PubMed PMID: 24172039; PubMed Central PMCID: PMC3834876.

Rayner EL, Pearson GR, Hall GA, Basaraba RJ, Gleeson F, McIntyre A, Clark S,  Williams A, Dennis MJ, Sharpe SA. Early lesions following aerosol infection of rhesus macaques (Macaca mulatta) with Mycobacterium tuberculosis strain H37RV. J  Comp Pathol. 2013 Nov;149(4):475-85. doi: 10.1016/j.jcpa.2013.05.005. Epub 2013 Jul 21. PubMed PMID: 23880551.

Safi H, Lingaraju S, Amin A, Kim S, Jones M, Holmes M, McNeil M, Peterson SN, Chatterjee D, Fleischmann R, Alland D. Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes. Nat Genet. 2013 Oct;45(10):1190-7. doi: 10.1038/ng.2743. Epub 2013 Sep 1. PubMed PMID: 23995136.

Schenkel AR, Kingry LC, Slayden RA. The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection. Front Immunol. 2013 Apr 16;4:90. doi: 10.3389/fimmu.2013.00090. eCollection 2013. PubMed PMID: 23596445; PubMed Central PMCID: PMC3627126.

Shanley CA, Streicher EM, Warren RM, Victor TC, Orme IM. Characterization of  W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape. Vaccine.  2013 Dec 5;31(50):5934-9. doi: 10.1016/j.vaccine.2013.10.044. Epub 2013 Oct 19. PubMed PMID: 24144471; PubMed Central PMCID: PMC3886241.

Silva EB, Goodyear A, Sutherland MD, Podnecky NL, Gonzalez-Juarrero M, Schweizer HP, Dow SW. Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine. Infect Immun.  2013 Dec;81(12):4626-34. doi: 10.1128/IAI.00915-13. Epub 2013 Oct 7. PubMed PMID: 24101688; PubMed Central PMCID: PMC3837973.

Slayden RA, Jackson M, Zucker J, Ramirez MV, Dawson CC, Crew R, Sampson NS, Thomas ST, Jamshidi N, Sisk P, Caspi R, Crick DC, McNeil MR, Pavelka MS, Niederweis M, Siroy A, Dona V, McFadden J, Boshoff H, Lew JM. Updating and curating metabolic pathways of TB. Tuberculosis (Edinb). 2013 Jan;93(1):47-59. doi: 10.1016/j.tube.2012.11.001. Epub 2013 Feb 1. Review. PubMed PMID: 23375378; PubMed Central PMCID: PMC4121119.

Souza C, Davis WC, Eckstein TM, Sreevatsan S, Weiss DJ. Mannosylated lipoarabinomannans from Mycobacterium avium subsp. paratuberculosis alters the inflammatory response by bovine macrophages and suppresses killing of Mycobacterium avium subsp. avium organisms. PLoS One. 2013 Sep 30;8(9):e75924. doi: 10.1371/journal.pone.0075924. eCollection 2013. PubMed PMID: 24098744; PubMed Central PMCID: PMC3786972.

Speer A, Shrestha TB, Bossmann SH, Basaraba RJ, Harber GJ, Michalek SM, Niederweis M, Kutsch O, Wolschendorf F. Copper-boosting compounds: a novel concept for antimycobacterial drug discovery. Antimicrob Agents Chemother. 2013 Feb;57(2):1089-91. doi: 10.1128/AAC.01781-12. Epub 2012 Dec 17. PubMed PMID: 23254420; PubMed Central PMCID: PMC3553712.

Sun J, Singh V, Lau A, Stokes RW, Obregón-Henao A, Orme IM, Wong D, Av-Gay Y, Hmama Z. Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. PLoS Pathog. 2013;9(7):e1003499. doi: 10.1371/journal.ppat.1003499. Epub 2013 Jul 18. PubMed PMID: 23874203; PubMed Central PMCID: PMC3715411.

Thirunavukkarasu S, Plain KM, Eckstein TM, de Silva K, Whittington RJ. Cellular and humoral immunogenicity of Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigens. Res Vet Sci. 2013 Aug;95(1):123-9. doi: 10.1016/j.rvsc.2013.03.002. Epub 2013 Mar 27. PubMed PMID:  23540605.

Weng X, Xing Y, Liu J, Wang Y, Ning Y, Li M, Wu W, Zhang L, Li W, Heiden JV,  Vissa V. Molecular, ethno-spatial epidemiology of leprosy in China: novel insights for tracing leprosy in endemic and non endemic provinces. Infect Genet Evol. 2013 Mar;14:361-8. doi: 10.1016/j.meegid.2012.12.009. Epub 2013 Jan 4. PubMed PMID: 23291419; PubMed Central PMCID: PMC3668695.

Wolfe LM, Veeraraghavan U, Idicula-Thomas S, Schürer S, Wennerberg K, Reynolds R, Besra GS, Dobos KM. A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis. Mol Cell Proteomics. 2013 Jun;12(6):1644-60. doi: 10.1074/mcp.M112.025635. Epub 2013 Mar 5. PubMed PMID: 23462205; PubMed Central PMCID: PMC3675820.

Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel  Y, Zhang P, Ojha AK. Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. J Biol Chem. 2013 Jan 4;288(1):382-92. doi: 10.1074/jbc.M112.419754. Epub 2012 Nov 15. PubMed PMID: 23155047; PubMed Central PMCID: PMC3537035.

Adams MK, Goodrich LR, Rao S, Olea-Popelka F, Phillips N, Kisiday JD, McIlwraith CW. Equine bone marrow-derived mesenchymal stromal cells (BMDMSCs) from the ilium and sternum: are there differences? Equine Vet J. 2013 May;45(3):372-5. doi: 10.1111/j.2042-3306.2012.00646.x. Epub 2012 Sep 26. PubMed PMID: 23009322; PubMed Central PMCID: PMC3581704.

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Fávaro WJ, Nunes OS, Seiva FR, Nunes IS, Woolhiser LK, Durán N, Lenaerts AJ.  Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer. Infect Agent Cancer. 2012 Jun 18;7(1):14. doi: 10.1186/1750-9378-7-14. PubMed PMID: 22709446; PubMed Central PMCID: PMC3408364.

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Geluk A, Bobosha K, van der Ploeg-van Schip JJ, Spencer JS, Banu S, Martins MV, Cho SN, Franken KL, Kim HJ, Bekele Y, Uddin MK, Hadi SA, Aseffa A, Pessolani MC, Pereira GM, Dockrell HM, Ottenhoff TH. New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy. J Immunol. 2012 May 15;188(10):4782-91. doi: 10.4049/jimmunol.1103452. Epub 2012 Apr 13. PubMed PMID: 22504648; PubMed Central PMCID: PMC3345093.

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Grant KR, Campbell TW, Silver TI, Olea-Popelka FJ. Validation of an ultrasound-guided technique to establish a liver-to-coelom ratio and a comparative analysis of the ratios among acclimated and recently wild-caught southern stingrays, Dasyatis americana. Zoo Biol. 2013 Jan-Feb;32(1):104-11. doi: 10.1002/zoo.21014. Epub 2012 May 15. PubMed PMID: 22588699.

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Henneveld K, Rosychuk RA, Olea-Popelka FJ, Hyatt DR, Zabel S. Corynebacterium spp. in dogs and cats with otitis externa and/or media: a retrospective study. J  Am Anim Hosp Assoc. 2012 Sep-Oct;48(5):320-6. doi: 10.5326/JAAHA-MS-5791. Epub 2012 Jul 27. PubMed PMID: 22843832.

Kato-Maeda M, Shanley CA, Ackart D, Jarlsberg LG, Shang S, Obregon-Henao A, Harton M, Basaraba RJ, Henao-Tamayo M, Barrozo JC, Rose J, Kawamura LM, Coscolla  M, Fofanov VY, Koshinsky H, Gagneux S, Hopewell PC, Ordway DJ, Orme IM. Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig. Clin Vaccine Immunol. 2012 Aug;19(8):1227-37. doi: 10.1128/CVI.00250 12. Epub 2012 Jun 20. PubMed PMID: 22718126; PubMed Central PMCID: PMC3416080.

Ketusing N, Reeves A, Portacci K, Yano T, Olea-Popelka F, Keefe T, Salman M.  Evaluation of strategies for the eradication of Pseudorabies virus (Aujeszky’s disease) in commercial swine farms in Chiang-Mai and Lampoon Provinces, Thailand, using a simulation disease spread model. Transbound Emerg Dis. 2014 Apr;61(2):169-76. doi: 10.1111/tbed.12017. Epub 2012 Oct 3. PubMed PMID: 23033968.

Kim HJ, Prithiviraj K, Groathouse N, Brennan PJ, Spencer JS. Gene expression  profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real time PCR. Clin Vaccine Immunol. 2013 Feb;20(2):181-90. doi: 10.1128/CVI.00419-12. Epub 2012 Dec 12. PubMed PMID:  23239802; PubMed Central PMCID: PMC3571279.

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Kuruwa S, Vissa V, Mistry N. Distribution of Mycobacterium leprae strains among cases in a rural and urban population of Maharashtra, India. J Clin Microbiol. 2012 Apr;50(4):1406-11. doi: 10.1128/JCM.05315-11. Epub 2012 Jan 11. PubMed PMID: 22205800; PubMed Central PMCID: PMC3318501.

Lamont EA, O’Grady SM, Davis WC, Eckstein T, Sreevatsan S. Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1β release and macrophage transepithelial migration. Infect Immun. 2012 Sep;80(9):3225-35. doi: 10.1128/IAI.06322-11. Epub 2012 Jul 9. PubMed PMID: 22778093; PubMed Central PMCID: PMC3418758.

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Li W, Matsuoka M, Kai M, Thapa P, Khadge S, Hagge DA, Brennan PJ, Vissa V. Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types. J Clin Microbiol. 2012 Mar;50(3):742-53. doi: 10.1128/JCM.05183-11. Epub 2011 Dec 14. PubMed PMID: 22170923; PubMed Central PMCID: PMC3295127.

Mahapatra S, Piechota C, Gil F, Ma Y, Huang H, Scherman MS, Jones V, Pavelka  MS Jr, Moniz-Pereira J, Pimentel M, McNeil MR, Crick DC. Mycobacteriophage Ms6 LysA: a peptidoglycan amidase and a useful analytical tool. Appl Environ Microbiol. 2013 Feb;79(3):768-73. doi: 10.1128/AEM.02263-12. Epub 2012 Nov 16. PubMed PMID: 23160121; PubMed Central PMCID: PMC3568546.

Mahapatra S, Woolhiser LK, Lenaerts AJ, Johnson JL, Eisenach KD, Joloba ML, Boom WH, Belisle JT. A novel metabolite of antituberculosis therapy demonstrates  host activation of isoniazid and formation of the isoniazid-NAD+ adduct. Antimicrob Agents Chemother. 2012 Jan;56(1):28-35. doi: 10.1128/AAC.05486-11. Epub 2011 Oct 28. PubMed PMID: 22037847; PubMed Central PMCID: PMC3256082.

Martins MV, Guimarães MM, Spencer JS, Hacker MA, Costa LS, Carvalho FM, Geluk A, van der Ploeg-van Schip JJ, Pontes MA, Gonçalves HS, de Morais JP, Bandeira TJ, Pessolani MC, Brennan PJ, Pereira GM. Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy. PLoS Negl Trop Dis. 2012;6(4):e1616. doi: 10.1371/journal.pntd.0001616. Epub 2012 Apr 24. PubMed PMID: 22545169; PubMed Central PMCID: PMC3335884.

Mathebula N, Miller M, Buss P, Joubert J, Martin L, Kruger M, Hofmeyr M, Olea-Popelka F. Biochemical values in free-ranging white rhinoceros (Ceratotherium simum) in Kruger National Park, South Africa. J Zoo Wildl Med. 2012 Sep;43(3):530-8. PubMed PMID: 23082517.

Mathema B, Kurepina N, Yang G, Shashkina E, Manca C, Mehaffy C, Bielefeldt-Ohmann H, Ahuja S, Fallows DA, Izzo A, Bifani P, Dobos K, Kaplan G, Kreiswirth BN. Epidemiologic consequences of microvariation in Mycobacterium tuberculosis. J Infect Dis. 2012 Mar 15;205(6):964-74. doi: 10.1093/infdis/jir876. Epub 2012 Feb 7. PubMed PMID: 22315279; PubMed Central PMCID: PMC3415951.

McShane H, Jacobs WR, Fine PE, Reed SG, McMurray DN, Behr M, Williams A, Orme IM. BCG: myths, realities, and the need for alternative vaccine strategies. Tuberculosis (Edinb). 2012 May;92(3):283-8. doi: 10.1016/j.tube.2011.12.003. Epub 2012 Feb 18. PubMed PMID: 22349516.

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Miller M, Olea-Popelka F. One Health in the shrinking world: experiences with tuberculosis at the human-livestock-wildlife interface. Comp Immunol Microbiol Infect Dis. 2013 May;36(3):263-8. doi: 10.1016/j.cimid.2012.07.005. Epub 2012 Aug 22. Review. PubMed PMID: 22921281.

Miller M, Olea-Popelka F, Joubert J, Mathebula N, Zimmerman D, Hausler G, Dreyer C, Hofmeyr M, Buss P. Serum iron and selected biochemical values in free-ranging black rhinoceros (Diceros bicornis) from South Africa. J Zoo Wildl Med. 2012 Sep;43(3 Suppl):S55-60. PubMed PMID: 23156706.

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Molins CR, Delorey MJ, Young JW, Yockey BM, Belisle JT, Schriefer ME, Petersen JM. Use of temperature for standardizing the progression of Francisella  tularensis in mice. PLoS One. 2012;7(9):e45310. doi: 10.1371/journal.pone.0045310. Epub 2012 Sep 24. PubMed PMID: 23028924; PubMed Central PMCID: PMC3454384.

Muwonge A, Johansen TB, Vigdis E, Godfroid J, Olea-Popelka F, Biffa D, Skjerve E, Djønne B. Mycobacterium bovis infections in slaughter pigs in Mubende  district, Uganda: a public health concern. BMC Vet Res. 2012 Sep 21;8:168. doi: 10.1186/1746-6148-8-168. PubMed PMID: 22999303; PubMed Central PMCID: PMC3526550.

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Parlane NA, Compton BJ, Hayman CM, Painter GF, Basaraba RJ, Heiser A, Buddle BM. Phosphatidylinositol di-mannoside and derivates modulate the immune response  to and efficacy of a tuberculosis protein vaccine against Mycobacterium bovis infection. Vaccine. 2012 Jan 11;30(3):580-8. doi: 10.1016/j.vaccine.2011.11.055.  Epub 2011 Nov 24. PubMed PMID: 22120192.

Parlane NA, Grage K, Mifune J, Basaraba RJ, Wedlock DN, Rehm BH, Buddle BM. Vaccines displaying mycobacterial proteins on biopolyester beads stimulate cellular immunity and induce protection against tuberculosis. Clin Vaccine Immunol. 2012 Jan;19(1):37-44. doi: 10.1128/CVI.05505-11. Epub 2011 Nov 9. PubMed PMID: 22072720; PubMed Central PMCID: PMC3255957.

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Péterfia B, Füle T, Baghy K, Szabadkai K, Fullár A, Dobos K, Zong F, Dobra K, Hollósi P,  Jeney A, Paku S, Kovalszky I.  Syndecan-1 enhances proliferation, migration and metastasis  of HT-1080 cells in cooperation with syndecan-2.  PLoS One. 2012; 7(6):e39474. doi: 10.1371/journal.pone.0039474. Epub 2012 Jun 26.

Phetsuksiri B, Srisungngam S, Rudeeaneksin J, Bunchoo S, Lukebua A, Wongtrungkapun R, Paitoon S, Sakamuri RM, Brennan PJ, Vissa V. SNP genotypes of Mycobacterium leprae isolates in Thailand and their combination with rpoT and TTC genotyping for analysis of leprosy distribution and transmission. Jpn J Infect Dis. 2012;65(1):52-6. PubMed PMID: 22274158.

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Shang S, Shanley CA, Caraway ML, Orme EA, Henao-Tamayo M, Hascall-Dove L, Ackart D, Orme IM, Ordway DJ, Basaraba RJ. Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis. Vaccine. 2012 Feb 21;30(9):1572-82. doi: 10.1016/j.vaccine.2011.12.114. Epub 2012 Jan 11. PubMed PMID: 22244979; PubMed Central PMCID: PMC3286658.

Shikani AH, Kourelis K, Rohayem Z, Basaraba RJ, Leid JG. Topical gel therapy for sinonasal polyposis in Samter’s triad: preliminary report. Ann Otol Rhinol Laryngol. 2012 Nov;121(11):719-24. PubMed PMID: 23193904.

Slayden RA, Jackson M, Zucker J, Ramirez MV, Dawson CC, Crew R, Sampson NS, Thomas ST, Jamshidi N, Sisk P, Caspi R, Crick DC, McNeil MR, Pavelka MS, Niederweis M, Siroy A, Dona V, McFadden J, Boshoff H, Lew JM. Updating and curating metabolic pathways of TB. Tuberculosis (Edinb). 2013 Jan;93(1):47-59. doi: 10.1016/j.tube.2012.11.001. Epub 2013 Feb 1. Review. PubMed PMID: 23375378;  PubMed Central PMCID: PMC4121119.

Somashekar BS, Amin AG, Tripathi P, MacKinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, Orme IM, Ordway DJ, Chatterjee D. Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis. J Proteome Res. 2012 Oct 5;11(10):4873-84. doi: 10.1021/pr300345x. Epub 2012 Aug 30. PubMed  PMID: 22873951.

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Sutherland MD, Goodyear AW, Troyer RM, Chandler JC, Dow SW, Belisle JT. Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia. Vaccine. 2012 Jul 13;30(33):4977-82. doi: 10.1016/j.vaccine.2012.05.037. Epub 2012 May 28. PubMed PMID: 22652404; PubMed Central PMCID: PMC3576924.

Tatham E, Sundaram Chavadi S, Mohandas P, Edupuganti UR, Angala SK, Chatterjee D, Quadri LE. Production of mycobacterial cell wall glycopeptidolipids requires a member of the MbtH-like protein family. BMC Microbiol. 2012 Jun 22;12:118. doi: 10.1186/1471-2180-12-118. PubMed PMID: 22726990; PubMed Central PMCID: PMC3537567.

Taylor JL, Wieczorek A, Keyser AR, Grover A, Flinkstrom R, Karls RK, Bielefeldt-Ohmann H, Dobos KM, Izzo AA. HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule. Immunol Cell Biol. 2012 Nov;90(10):945-54. doi: 10.1038/icb.2012.34. Epub 2012 Jul 17. PubMed  PMID: 22801575; PubMed Central PMCID: PMC3511932.

Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 2012 Aug;22(8):1118-27. doi: 10.1093/glycob/cws078. Epub 2012 Apr 25. PubMed PMID: 22534567; PubMed Central PMCID: PMC3382347.

Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME. Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria. J Biol Chem. 2012 Jul 13;287(29):24649-61. doi: 10.1074/jbc.M112.368191. Epub 2012 May 25. PubMed PMID: 22637481; PubMed Central  PMCID: PMC3397893.

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Walter ND, Strong M, Belknap R, Ordway DJ, Daley CL, Chan ED. Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis. Respirology. 2012 Jul;17(5):772-91. doi: 10.1111/j.1440-1843.2012.02176.x. Review. PubMed PMID: 22458269.

Yang H, Kruh-Garcia NA, Dobos KM. Purified protein derivatives of tuberculin–past, present, and future. FEMS Immunol Med Microbiol. 2012 Dec;66(3):273-80. doi: 10.1111/j.1574-695X.2012.01002.x. Epub 2012 Aug 1. Review. PubMed PMID: 22762692; PubMed Central PMCID: PMC3491170.

Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel Y, Zhang P, Ojha AK. Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. J Biol Chem. 2013 Jan 4;288(1):382-92. doi: 10.1074/jbc.M112.419754. Epub 2012 Nov 15. PubMed PMID: 23155047; PubMed Central PMCID: PMC3537035.

Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC. Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161. Open AIDS J. 2011; 5:86-95. Epub 2011 Oct 19.

Palanisamy GS, Kirk NM, Ackart DF, Shanley CA, Orme IM, Basaraba RJ. Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis. PLoS One. 2011; 6(10):e26254. Epub 2011 Oct 18.

Kenyon CL, Basaraba RJ, Bohn AA. Influence of endurance exercise on serum concentrations of iron and acute phase proteins in racing sled dogs. J Am Vet Med Assoc. 2011 Nov 1; 239(9):1201-10.

Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis. 2012 Jan 1; 205(1):152-61. Epub 2011 Oct 11.

Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA. Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest. 2011 Sep; 121(9):3554-63. doi: 10.1172/JCI46095. Epub 2011 Aug 1.

Ordway DJ, Shang S, Henao-Tamayo M, Obregon-Henao A, Nold L, Caraway M, Shanley CA, Basaraba RJ, Duncan CG, Orme IM. Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells. Clin Vaccine Immunol. 2011 Sep; 18(9):1527-35. Epub 2011 Jul 27.

Shang S, Harton M, Tamayo MH, Shanley C, Palanisamy GS, Caraway M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ. Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. Tuberculosis (Edinb). 2011 Sep; 91(5):378-85. Epub 2011 Jul 6.

Somashekar BS, Amin AG, Rithner CD, Troudt J, Basaraba R, Izzo A, Crick DC, Chatterjee D. Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies. J Proteome Res. 2011 Sep 2; 10(9):4186-95. Epub 2011 Jul 26.

Obregón-Henao A, Shanley C, Bianco MV, Cataldi AA, Basaraba RJ, Orme IM, Bigi F. Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis. Vaccine. 2011 Jun 10; 29(26):4302-7. Epub 2011 Apr 22.

Dharmadhikari AS, Basaraba RJ, Van Der Walt ML, Weyer K, Mphahlele M, Venter K, Jensen PA, First MW, Parsons S, McMurray DN, Orme IM, Nardell EA. Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis. Tuberculosis (Edinb). 2011 Jul; 91(4):329-38. Epub 2011 Apr 7.

Hoff DR, Ryan GJ, Driver ER, Ssemakulu CC, De Groote MA, Basaraba RJ, Lenaerts AJ. Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment. PLoS One. 2011 Mar 21; 6(3):e17550.

Shang S, Ordway D, Henao-Tamayo M, Bai X, Oberley-Deegan R, Shanley C, Orme IM, Case S, Minor M, Ackart D, Hascall-Dove L, Ovrutsky AR, Kandasamy P, Voelker DR, Lambert C, Freed BM, Iseman MD, Basaraba RJ, Chan ED. Cigarette smoke increases susceptibility to tuberculosis–evidence from in vivo and in vitro models.  J Infect Dis. 2011 May 1;203(9):1240-8. Epub 2011 Feb 28.

Wolschendorf F, Ackart D, Shrestha TB, Hascall-Dove L, Nolan S, Lamichhane G, Wang Y, Bossmann SH, Basaraba RJ, Niederweis M. Copper resistance is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1621-6. Epub 2011 Jan 4.

Nahid P, Saukkonen J, Mac Kenzie WR, Johnson JL, Phillips PP, Andersen J, Bliven-Sizemore E, Belisle JT, Boom WH, Luetkemeyer A, Campbell TB, Eisenach KD, Hafner R, Lennox JL, Makhene M, Swindells S, Villarino ME, Weiner M, Benson C, Burman W; National Institutes of Health; Centers for Disease Control and Prevention. CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap. Am J Respir Crit Care Med. 2011 Oct 15; 184(8):972-9. doi: 10.1164/rccm.201105-0827WS.

Bhamidi S, Scherman MS, Jones V, Crick DC, Belisle JT, Brennan PJ, McNeil MR. Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis. J Biol Chem. 2011 Jul 1; 286(26):23168-77. Epub 2011 May 9.

Chandler JC, Molins CR, Petersen JM, Belisle JT. Differential chitinase activity and production within Francisella species, subspecies, and subpopulations. J Bacteriol. 2011 Jul; 193(13):3265-75. Epub 2011 Apr 29.

Sartain MJ, Dick DL, Rithner CD, Crick DC, Belisle JT. Lipidomic analyses of Mycobacterium tuberculosis based on accurate mass measurements and the novel “Mtb LipidDB”. J Lipid Res. 2011 May; 52(5):861-72. Epub 2011 Feb 1.

Basile F, Sibray T, Belisle JT, Bowen RA. Analysis of lipids from crude lung tissue extracts by desorption electrospray ionization mass spectrometry and pattern recognition. Anal Biochem. 2011 Jan 15; 408(2):289-96. Epub 2010 Sep 22.

Lobato J, Costa MP, Reis Ede M, Gonçalves MA, Spencer JS, Brennan PJ, Goulart LR, Goulart IM. Comparison of three immunological tests for leprosy diagnosis and detection of subclinical infection. Lepr Rev. 2011 Dec; 82(4):389-401.

Spencer JS, Brennan PJ. The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy. Lepr Rev. 2011 Dec; 82(4):344-57.

Brennan PJ. Future for laboratory based research for leprosy. Lepr Rev. 2011 Dec;82(4):330-3.

Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB. Invariant natural killer T cells recognize lipid self-antigen induced by microbial danger signals. Nat Immunol. 2011 Oct 30;12(12):1202-11. doi: 10.1038/ni.2143.

Al-Mubarak R, Vander Heiden J, Broeckling CD, Balagon M, Brennan PJ, Vissa VD. Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1303. Epub 2011 Sep 6.

Li W, Sakamuri RM, Lyons DE, Orcullo FM, Shinde V, Dela Pena EL, Maghanoy AA, Mallari IB, Tan EV, Nath I, Brennan PJ, Balagon M, Vissa V. Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches. Antimicrob Agents Chemother. 2011 Nov; 55(11):5384-7. Epub 2011 Aug 22.

Stavri H, Ulea I, Radu DL, Branaru MG, Moldovan O, Bogdan MA, Tudose C, Raileanu M, Duiculescu D, Ene L, Olar V, Ionita C, Popa GL, Popa MI, Brennan PJ. Serodiagnosis of environmental mycobacterial infections. J Microbiol Methods. 2011 Sep; 86(3):283-90. Epub 2011 May 20.

Spencer JS, Kim HJ, Wheat WH, Chatterjee D, Balagon MV, Cellona RV, Tan EV, Gelber R, Saunderson P, Duthie MS, Reece ST, Burman W, Belknap R, Mac Kenzie WR, Geluk A, Oskam L, Dockrell HM, Brennan PJ; IDEAL Consortium. Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy. Clin Vaccine Immunol. 2011 Feb; 18(2):260-7. Epub 2010 Dec 22.

Zhang J, Angala SK, Pramanik PK, Li K, Crick DC, Liav A, Jozwiak A, Swiezewska E, Jackson M, Chatterjee D. Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors. ACS Chem Biol. 2011 Aug 19; 6(8):819-28. doi: 10.1021/cb200091m. Epub 2011 May 26.

Dhiman RK, Dinadayala P, Ryan GJ, Lenaerts AJ, Schenkel AR, Crick DC.  Lipoarabinomannan localization and abundance during growth of Mycobacterium smegmatis.  J Bacteriol. 2011 Oct; 193(20):5802-9. doi: 10.1128/JB.05299-11. Epub 2011 Aug 12.

Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y.  Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.  J Med Chem. 2011 Jul 14; 54(13):4721-34. Epub 2011 Jun 2.

Magden ER, Weiner CM, Gilliland JC, DeGroote MA, Lenaerts AJ, Kendall LV.  Torticollis in mice intravenously infected with Mycobacterium tuberculosis.  J Am Assoc Lab Anim Sci. 2011 Mar; 50(2):244-7.

Yang H, Troudt J, Grover A, Arnett K, Lucas M, Cho YS, Bielefeldt-Ohmann H, Taylor J, Izzo A, Dobos KM.  Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.  Infect Immun. 2011 Feb; 79(2):716-23. doi: 10.1128/IAI.00486-10. Epub 2010 Dec 6.

Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL. Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp. 2011 May 2; (51). pii: 2702. doi: 10.3791/2702PMID:21587154  [PubMed – indexed for MEDLINE]

Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M.  Local pulmonary immunotherapy with siRNA targeting TGFß1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. Tuberculosis (Edinb). 2011 Jan; 91(1):98-106. Epub 2010 Dec 31.PMID:21195670 [PubMed – indexed for MEDLINE]

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Gonzalez–Juarrero, M. Immunity to tuberculosis and targets for immunotherapy.  Review in Immunotherapy. Editorial Future Medicine. In press

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Aagaard C., T. Hoang, J. Dietrich, Cardona P.–J., Izzo A., Dolganov G., Schoolnik G.K., Cassidy J., Billeskov R., Andersen P. (2011) A multistage tuberculosis vaccine that confers efficient protection pre– and post–exposure.  Nature Medicine 17(2):189-94

Brown, J. R., E. J. North, J. G. Hurdle, C. Morisseau, J. S. Scarborough, D. Sun, J. Korduláková, M. S. Scherman, V. Jones, A. Grzegorzewicz, R. M. Crew, M. Jackson, M. R. McNeil, and R. E. Lee (2011). The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem 19(18): 5585-5595.

Shang, S., S. Gibbs, M. Henao-Tamayo, C. A. Shanley, G. McDonnell, R. S. Duarte, D. J. Ordway, and M. Jackson (2011). Increased virulence of an epidemic strain of Mycobacterium massiliense in mice. PLoS ONE 6(9): e24726.

Dianišková, P., J. Korduláková, H. Škovierová, D. Kaur, M. Jackson, P. J. Brennan, and K. Mikušová (2011). Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster. Gen. Physiol. Biophys. 30:239-250.

Santangelo, M. P., P. M. Gest, M. E. Guerin, M. Coinçon, H. Pham, G. Ryan, S. E. Puckett, J. S. Spencer, M. Gonzalez-Juarrero, R. Daher, A. J. Lenaerts, D. Schnappinger, M. Therisod, S. Ehrt, J. Sygusch, and M. Jackson (2011). Glycolytic and non-glycolytic functions of the fructose-1,6-bisphosphate aldolase of Mycobacterium tuberculosis, an essential enzyme produced by replicating and non-replicating bacilli. J. Biol. Chem. 286(46): 40219-40231.

Mathew B, Srivastava S, Ross LJ, Suling WJ, White EL, Woolhiser LK, Lenaerts AJ, Reynolds RC.  Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.  Bioorg Med Chem. 2011 Dec 1; 19(23):7120-8. doi: 10.1016/j.bmc.2011.09.062. Epub 2011 Oct 5.

De Groote MA, Gilliland JC, Wells CL, Brooks EJ, Woolhiser LK, Gruppo V, Peloquin CA, Orme IM, Lenaerts AJ.  Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis.  Antimicrob Agents Chemother. 2011 Mar; 55(3):1237-47. doi: 10.1128/AAC.00595-10. Epub 2010 Dec 6.

Shang S, Shanley CA, Caraway ML, Orme EA, Henao-Tamayo M, Hascall-Dove L, Ackart D, Lenaerts AJ, Basaraba RJ, Orme IM, Ordway DJ.  Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs.  Antimicrob Agents Chemother. 2011 Jan; 55(1):124-31. doi: 10.1128/AAC.00978-10. Epub 2010 Oct 11.

Wang, Y., T. N. Hess, V. Jones, J. Z. Zhou, M. R. McNeil, and J. A. McCammon. 2011. Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening. Bioorganic & Medicinal Chemistry Letters 21:7064-7067.

Xiyuan Baia, Kathryn Chmura, Alida R. Ovrutsky, Russell P. Bowlerb, Robert Scheinmane Rebecca E. Oberley-Deegan, Haiying Liuf, Shaobin Shang, Diane Ordway, Edward D. Chan, M. tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription. Tuberculosis. 2011. 91:26-35.

Henao-Temayo M., Irwin S. M., Shang S., Ordway D. J., Orme I. M.  T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis.  Tuberculosis (Edinb).  2011.91.308-13.

Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med. 2011. doi: 10.1038/nm.

Ordway DJ, Orme IM.  Animal models of mycobacteria infection.  Curr Protoc Immunol. 2011 Aug;Chapter 19:Unit19.5. doi: 10.1002/0471142735.im1905s94.

McShane H, Jacobs WR, Fine PE, Reed SG, McMurray DN, Behr M, Williams A, Orme IM.  BCG: myths, realities, and the need for alternative vaccine strategies.  Tuberculosis (Edinb). 2012 May; 92(3):283-8. doi: 10.1016/j.tube.2011.12.003. Epub 2012 Feb 18.

Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr.  A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.  Nat Med. 2011 Sep 4; 17(10):1261-8. doi: 10.1038/nm.2420.

Ching LK, Mompoint F, Guderian JA, Picone A, Orme IM, Coler RN, Reed SG, Baldwin SL.  Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.  J Immunol Methods. 2011 Oct 28; 373(1-2):54-62. doi: 10.1016/j.jim.2011.07.021. Epub 2011 Aug 3.

Orme IM.  Development of new vaccines and drugs for TB: limitations and potential strategic errors.  Future Microbiol. 2011 Feb; 6(2):161-77. doi: 10.2217/fmb.10.168.

Li X, Liu N, Zhang H, Knudson SE, Li HJ, Lai CT, Simmerling C, Slayden RA, Tonge PJ.  CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.  ACS Med Chem Lett. 2011 Nov 10; 2(11):818-823.

England K, Crew R, Slayden RA.  Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response.  BMC Microbiol. 2011 Apr 19; 11:79. doi: 10.1186/1471-2180-11-79.

Liu N, Cummings JE, England K, Slayden RA, Tonge PJ.  Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.  J Antimicrob Chemother. 2011 Mar; 66(3):564-73. doi: 10.1093/jac/dkq509. Epub 2011 Jan 22.

Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR, Nunberg JH.  A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus.  J Biol Chem. 2011 Feb 25; 286(8):6192-200. doi: 10.1074/jbc.M110.196428. Epub 2010 Dec 15.

Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I.  Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.  J Med Chem. 2011 Jan 13; 54(1):374-81. doi: 10.1021/jm1012006. Epub 2010 Dec 2.

Kingry LC, Troyer RM, Marlenee NL, Bielefeldt-Ohmann H, Bowen RA, Schenkel AR, Dow SW, Slayden RA.  Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.  Microbes Infect. 2011 Mar; 13(3):261-75. doi: 10.1016/j.micinf.2010.10.022. Epub 2010 Nov 9.

Lahiri R, Randhawa B, Franken KL, Duthie MS, Spencer JS, Geluk A, Krahenbuhl JL.  Development of a mouse food pad model for detection of sub clinical leprosy.  Lepr Rev. 2011 Dec; 82(4):432-44.

Geluk A, Duthie MS, Spencer JS.  Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease.  Lepr Rev. 2011 Dec; 82(4):402-21.

Geluk A, van den Eeden SJ, Dijkman K, Wilson L, Kim HJ, Franken KL, Spencer JS, Pessolani MC, Pereira GM, Ottenhoff TH.  ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria.  J Immunol. 2011 Aug 1; 187(3):1393-402. doi: 10.4049/jimmunol.1100980. Epub 2011 Jun 24.

Duthie MS, Truman RW, Goto W, O’Donnell J, Hay MN, Spencer JS, Carter D, Reed SG.  Insight toward early diagnosis of leprosy through analysis of the developing antibody responses of Mycobacterium leprae-infected armadillos.  Clin Vaccine Immunol. 2011 Feb; 18(2):254-9. doi: 10.1128/CVI.00420-10. Epub 2010 Dec 22.

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Jensen RW, Rivest J, Li W, Vissa V.  DNA fingerprinting of Mycobacterium leprae strains using variable number tandem repeat (VNTR) – fragment length analysis (FLA).  J Vis Exp. 2011 Jul 15; (53):e3104. doi: 10.3791/3104.

Weng X, Vander Heiden J, Xing Y, Liu J, Vissa V.  Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.  Infect Genet Evol. 2011 Mar; 11(2):363-74. doi: 10.1016/j.meegid.2010.11.014. Epub 2010 Dec 1.

Discovery of anti-TB agents that target the cell-division protein FtsZ.  Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I.  Future Med Chem. 2010 Aug;2(8):1305-23.

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.  Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ.  Bioorg Med Chem Lett. 2010 Nov 1;20(21):6306-9.

An optical waveguide array biosensor for serology – biomed 2010.  Yan R, Lynn NS, Kingry LC, Slayden RA, Dandy DS, Lear KL.  Biomed Sci Instrum. 2010;46:45-50.

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.  Ryan GJ, Hoff DR, Driver ER, Voskuil MI, Gonzalez-Juarrero M, Basaraba RJ, Crick DC, Spencer JS, Lenaerts AJ.  PLoS One. 2010 Jun 14;5(6):e11108.

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.  Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, Malkinson AM.  J Leukoc Biol. 2010 Jul;88(1):159-68.

Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo.  Kruh NA, Troudt J, Izzo A, Prenni J, Dobos KM.  PLoS One. 2010 Nov 11;5(11):e13938.

BCG vaccination in the cotton rat (Sigmodon hispidus) infected by the pulmonary route with virulent Mycobacterium tuberculosis.  McFarland CT, Ly L, Jeevan A, Yamamoto T, Weeks B, Izzo A, McMurray D.  Tuberculosis (Edinb). 2010 Jul;90(4):262-7.

Initiation of acquired immunity in the lungs of mice lacking lymph nodes after infection with aerosolized Mycobacterium tuberculosis.  Kashino SS, Vallerskog T, Martens G, Troudt J, Keyser A, Taylor J, Izzo A, Kornfeld H, Campos-Neto A.  Am J Pathol. 2010 Jan;176(1):198-204.

Reduced transcript stabilization restricts TNF-alpha expression in RAW264.7 macrophages infected with pathogenic mycobacteria: evidence for an involvement of lipomannan.  Basler T, Holtmann H, Abel J, Eckstein T, Baumer W, Valentin-Weigand P, Goethe R.  J Leukoc Biol. 2010 Jan;87(1):173-83.

A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence.  Alonso-Hearn M, Eckstein TM, Sommer S, Bermudez LE.  Innate Immun. 2010 Aug;16(4):235-47.

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.  Ioerger TR, Feng Y, Chen X, Dobos KM, Victor TC, Streicher EM, Warren RM, Gey van Pittius NC, Van Helden PD, Sacchettini JC.  BMC Genomics. 2010 Nov 26;11:670.

Proteomic definition of the cell wall of Mycobacterium tuberculosis.  Wolfe LM, Mahaffey SB, Kruh NA, Dobos KM.  J Proteome Res. 2010 Nov 5;9(11):5816-26.

Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages.  Giri PK, Kruh NA, Dobos KM, Schorey JS.  Proteomics. 2010 Sep;10(17):3190-202.

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.  Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR Jr, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC.  J Bacteriol. 2010 Jul;192(14):3645-53.

Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis.  Mehaffy C, Hess A, Prenni JE, Mathema B, Kreiswirth B, Dobos KM.  Proteomics. 2010 May;10(10):1966-84.

Development of a plate-based scintillation proximity assay for the mycobacterial AftB enzyme involved in cell wall arabinan biosynthesis.  Zhang J, Amin AG, Hölemann A, Seeberger PH, Chatterjee D.  Bioorg Med Chem. 2010 Oct 1;18(19):7121-31.

A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae.  Zhang J, Chatterjee D, Brennan PJ, Spencer JS, Liav A.  Bioorg Med Chem Lett. 2010 Jun 1;20(11):3250-3.

Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis.  Romero IC, Mehaffy C, Burchmore RJ, Dobos-Elder K, Brennan P, Walker J.  Tuberculosis (Edinb). 2010 Jan;90(1):25-30.

Comparative genomic and phylogeographic analysis of Mycobacterium leprae.  Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamesipour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, Macdonald M, Sapkota BR, Spencer JS, Thomas J, Harshman K, Singh P, Busso P, Gattiker A, Rougemont J, Brennan PJ, Cole ST.  Nat Genet. 2009 Dec;41(12):1282-9. Epub 2009 Nov 1. Erratum in: Nat Genet. 2010 Apr;42(4):361. Khamispour, Ali [corrected to Khamesipour, Ali].

Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis.  Peltier P, Beláňová M, Dianišková P, Zhou R, Zheng RB, Pearcey JA, Joe M, Brennan PJ, Nugier-Chauvin C, Ferrières V, Lowary TL, Daniellou R, Mikušová K.  Chem Biol. 2010 Dec 22;17(12):1356-66.

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.  Skovierová H, Larrouy-Maumus G, Pham H, Belanová M, Barilone N, Dasgupta A, Mikusová K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson M.  J Biol Chem. 2010 Dec 31;285(53):41348-55.

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria.  Guerin ME, Korduláková J, Alzari PM, Brennan PJ, Jackson M.  J Biol Chem. 2010 Oct 29;285(44):33577-83.

Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients.  Deenadayalan A, Heaslip D, Rajendiran AA, Velayudham BV, Frederick S, Yang HL, Dobos K, Belisle JT, Raja A.  Mol Cell Proteomics. 2010 Mar;9(3):538-49.

Establishment of an aerosol challenge model of tuberculosis in rhesus macaques and an evaluation of endpoints for vaccine testing.  Sharpe SA, McShane H, Dennis MJ, Basaraba RJ, Gleeson F, Hall G, McIntyre A, Gooch K, Clark S, Beveridge NE, Nuth E, White A, Marriott A, Dowall S, Hill AV, Williams A, Marsh PD.  Clin Vaccine Immunol. 2010 Aug;17(8):1170-82.

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis.  Ordway DJ, Shanley CA, Caraway ML, Orme EA, Bucy DS, Hascall-Dove L, Henao-Tamayo M, Harton MR, Shang S, Ackart D, Kraft SL, Lenaerts AJ, Basaraba RJ, Orme IM.  Antimicrob Agents Chemother. 2010 May;54(5):1820-33.

Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria. Jani C, Eoh H, Lee JJ, Hamasha K, Sahana MB, Han JS, Nyayapathy S, Lee JY, Suh JW, Lee SH, Rehse SJ, Crick DC, Kang CM. BMC Microbiol. 2010 Dec 29;10:327.

DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon. Honaker RW, Dhiman RK, Narayanasamy P, Crick DC, Voskuil MI. J Bacteriol. 2010 Dec;192(24):6447-55.

Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Narayanasamy P, Eoh H, Brennan PJ, Crick DC. Chem Biol. 2010 Feb 26;17(2):117-22.

The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs. Brown AC, Eberl M, Crick DC, Jomaa H, Parish T. J Bacteriol. 2010 May;192(9):2424-33.

The Achilles heel of BCG.  Orme IM.  Tuberculosis (Edinb). 2010 Nov;90(6):329-32.

Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis.  Henao-Tamayo MI, Ordway DJ, Irwin SM, Shang S, Shanley C, Orme IM.  Clin Vaccine Immunol. 2010 Apr;17(4):618-25.

Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease.  Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ.  Am J Respir Cell Mol Biol. 2010 Oct;43(4):387-93.

A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis.  Bertholet S, Ireton GC, Ordway DJ, Windish HP, Pine SO, Kahn M, Phan T, Orme IM, Vedvick TS, Baldwin SL, Coler RN, Reed SG.  Sci Transl Med. 2010 Oct 13;2(53):53ra74. doi: 10.1126/scitranslmed.3001094.

The combination of rifampin plus moxifloxacin is synergistic for suppression of resistance but antagonistic for cell kill of Mycobacterium tuberculosis as determined in a hollow-fiber infection model.  Drusano GL, Sgambati N, Eichas A, Brown DL, Kulawy R, Louie A.  MBio. 2010 Aug 10;1(3). doi:pii: e00139-10.

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring.  Termentzi A, Khouri I, Gaslonde T, Prado S, Saint-Joanis B, Bardou F, Amanatiadou EP, Vizirianakis IS, Kordulakova J, Jackson M, Brosch R, Janin YL, Daffé M, Tillequin F, Michel S.  Eur J Med Chem. 2010 Dec;45(12):5833-47.

Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.  Daher R, Coinçon M, Fonvielle M, Gest PM, Guerin ME, Jackson M, Sygusch J, Therisod M.  J Med Chem. 2010 Nov 11;53(21):7836-42.

An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages.  Dasgupta A, Sureka K, Mitra D, Saha B, Sanyal S, Das AK, Chakrabarti P, Jackson M, Gicquel B, Kundu M, Basu J.  PLoS One. 2010 Aug 17;5(8):e12225.

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis.  Geluk A, Spencer JS, Bobosha K, Pessolani MC, Pereira GM, Banu S, Honoré N, Reece ST, MacDonald M, Sapkota BR, Ranjit C, Franken KL, Zewdie M, Aseffa A, Hussain R, Stefani MM, Cho SN, Oskam L, Brennan PJ, Dockrell HM; IDEAL Consortium.  Clin Vaccine Immunol. 2009 Mar;16(3):352-9.

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.  Gonzalez-Juarrero M, Kingry LC, Ordway DJ, Henao-Tamayo M, Harton M, Basaraba RJ, Hanneman WH, Orme IM, Slayden RA.  Am J Respir Cell Mol Biol. 2009 Apr;40(4):398-409.

Localized immunosuppressive environment in the foreign body response to implanted biomaterials.  Higgins DM, Basaraba RJ, Hohnbaum AC, Lee EJ, Grainger DW, Gonzalez-Juarrero M.  Am J Pathol. 2009 Jul;175(1):161-70.

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.  Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Lee EJ, Orme IM, Gonzalez-Juarrero M.  Tuberculosis (Edinb). 2009 Mar;89(2):149-57.

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.  Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M.  Am J Respir Cell Mol Biol. 2009 Aug;41(2):136-45.

Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosis.  Grover A, Taylor J, Troudt J, Keyser A, Arnett K, Izzo L, Rholl D, Izzo A.  Infect Immun. 2009 Nov;77(11):4837-46.

Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose.  Aagaard C, Hoang TT, Izzo A, Billeskov R, Troudt J, Arnett K, Keyser A, Elvang T, Andersen P, Dietrich J.  PLoS One. 2009 Jun 16;4(6):e5930.

Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis.  Xing Z, McFarland CT, Sallenave JM, Izzo A, Wang J, McMurray DN.  PLoS One. 2009 Jun 10;4(6):e5856.

Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.  Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC.  Vaccine. 2009 Jul 16;27(33):4412-23.

Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection.  Drumm JE, Mi K, Bilder P, Sun M, Lim J, Bielefeldt-Ohmann H, Basaraba R, So M, Zhu G, Tufariello JM, Izzo AA, Orme IM, Almo SC, Leyh TS, Chan J.  PLoS Pathog. 2009 May;5(5):e1000460. Epub 2009 May 29. Erratum in: PLoS Pathog. 2009 Sep;5(9). doi: 10.1371/annotation/2b1a4b06-9558-448b-a8e8-5e2d407816a0.

A novel cell wall lipopeptide is important for biofilm formation and pathogenicity of Mycobacterium avium subspecies paratuberculosis.  Wu CW, Schmoller SK, Bannantine JP, Eckstein TM, Inamine JM, Livesey M, Albrecht R, Talaat AM.  Microb Pathog. 2009 Apr;46(4):222-30.

A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis.  Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E, Levillain F, Taylor ME, Drickamer K, Nigou J, Dobos KM, Puzo G, Vestweber D, Wild MK, Marcinko M, Sobieszczuk P, Stewart L, Lebus D, Gicquel B, Neyrolles O.  J Exp Med. 2009 Sep 28;206(10):2205-20.

The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.  Maloney E, Stankowska D, Zhang J, Fol M, Cheng QJ, Lun S, Bishai WR, Rajagopalan M, Chatterjee D, Madiraju MV.  PLoS Pathog. 2009 Jul;5(7):e1000534.

Lipoglycans of Mycobacterium tuberculosis: isolation, purification, and characterization.  Shi L, Torrelles JB, Chatterjee D.  Methods Mol Biol. 2009;465:23-45.

A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A.  Stalford SA, Fascione MA, Sasindran SJ, Chatterjee D, Dhandayuthapani S, Turnbull WB.  Chem Commun (Camb). 2009 Jan 7;(1):110-2.

Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.  Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, Schlesinger LS.  J Biol Chem. 2008 Nov 14;283(46):31417-28.

The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.  Eoh H, Brennan PJ, Crick DC.  Tuberculosis (Edinb). 2009 Jan;89(1):1-11.

Polymethylated polysaccharides from Mycobacterium species revisited.  Jackson M, Brennan PJ.  J Biol Chem. 2009 Jan 23;284(4):1949-53.

Approaches to developing new drugs against tuberculosis.  Brennan PJ.  Tuberculosis (Edinb). 2009 Sep;89(5):329-30. Epub 2009 Oct 12. No abstract available.

Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.  Kaur D, Guerin ME, Skovierová H, Brennan PJ, Jackson M.  Adv Appl Microbiol. 2009;69:23-78.

Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.  Scherman H, Kaur D, Pham H, Skovierová H, Jackson M, Brennan PJ.  J Bacteriol. 2009 Nov;191(21):6769-72.

AftD, a novel essential arabinofuranosyltransferase from mycobacteria.  Skovierová H, Larrouy-Maumus G, Zhang J, Kaur D, Barilone N, Korduláková J, Gilleron M, Guadagnini S, Belanová M, Prevost MC, Gicquel B, Puzo G, Chatterjee D, Brennan PJ, Nigou J, Jackson M.  Glycobiology. 2009 Nov;19(11):1235-47.

New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB’ is an essential enzyme of Mycobacterium smegmatis.  Guerin ME, Kaur D, Somashekar BS, Gibbs S, Gest P, Chatterjee D, Brennan PJ, Jackson M.  J Biol Chem. 2009 Sep 18;284(38):25687-96.

Population-based molecular epidemiology of leprosy in Cebu, Philippines.  Sakamuri RM, Kimura M, Li W, Kim HC, Lee H, Kiran MD, Black WC 4th, Balagon M, Gelber R, Cho SN, Brennan PJ, Vissa V.  J Clin Microbiol. 2009 Sep;47(9):2844-54.

Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria.  Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson M.  PLoS One. 2009;4(5):e5447.

Rapid variable-number tandem-repeat genotyping for Mycobacterium leprae clinical specimens.  Kimura M, Sakamuri RM, Groathouse NA, Rivoire BL, Gingrich D, Krueger-Koplin S, Cho SN, Brennan PJ, Vissa V.  J Clin Microbiol. 2009 Jun;47(6):1757-66.

Defining mycobacteria: Shared and specific genome features for different lifestyles.  Vissa VD, Sakamuri RM, Li W, Brennan PJ.  Indian J Microbiol. 2009 Mar;49(1):11-47. doi: 10.1007/s12088-009-0006-0.

Heparin-binding hemagglutinin (HBHA) of Mycobacterium leprae is expressed during infection and enhances bacterial adherence to epithelial cells.  de Lima CS, Marques MA, Debrie AS, Almeida EC, Silva CA, Brennan PJ, Sarno EN, Menozzi FD, Pessolani MC.  FEMS Microbiol Lett. 2009 Mar;292(2):162-9.

IFNgamma response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia.  del Corral H, París SC, Marín ND, Marín DM, López L, Henao HM, Martínez T, Villa L, Barrera LF, Ortiz BL, Ramírez ME, Montes CJ, Oquendo MC, Arango LM, Riaño F, Aguirre C, Bustamante A, Belisle JT, Dobos K, Mejía GI, Giraldo MR, Brennan PJ, Robledo J, Arbeláez MP, Rojas CA, García LF.  PLoS One. 2009 Dec 14;4(12):e8257.

Characterisation of short tandem repeats for genotyping Mycobacterium leprae.  Gillis T, Vissa V, Matsuoka M, Young S, Richardus JH, Truman R, Hall B, Brennan P; Ideal Consortium Partners.  Lepr Rev. 2009 Sep;80(3):250-60.

Genetic diversity of mycobacterium leprae isolates from Brazilian leprosy patients. Fontes AN, Sakamuri RM, Baptista IM, Ura S, Moraes MO, Martínez AN, Sarno EN, Brennan PJ, Vissa VD, Suffys PN.  Lepr Rev. 2009 Sep;80(3):302-15.

Molecular epidemiology of leprosy based on VNTR typing in Thailand.  Srisungnam S, Rudeeaneksin J, Lukebua A, Wattanapokayakit S, Pasadorn S, Mahotarn K, Ajincholapan, Sakamuri RM, Kimura M, Brennan PJ, Phetsuksiri B, Vissa V.  Lepr Rev. 2009 Sep;80(3):280-9.

A continuation: study and characterisation of Mycobacterium leprae short tandem repeat genotypes and transmission of leprosy in Cebu, Philippines.  Sakamuri RM, Harrison J, Gelber R, Saunderson P, Brennan PJ, Balagon M, Vissa V.  Lepr Rev. 2009 Sep;80(3):272-9.

IDEAL: in the footsteps of IMMLEP and THELEP.  Brennan PJ.  Lepr Rev. 2009 Sep;80(3):236-45.

Peptides of a novel Mycobacterium tuberculosis-specific cell wall protein for immunodiagnosis of tuberculosis.  Singh KK, Sharma N, Vargas D, Liu Z, Belisle JT, Potharaju V, Wanchu A, Behera D, Laal S.  J Infect Dis. 2009 Aug 15;200(4):571-81.

Isosation of mycobacterium species genomic DNA.  Belisle JT, Mahaffey SB, Hill PJ.  Methods Mol Biol. 2009;465:1-12.

Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis.  Slayden RA, Belisle JT.  J Antimicrob Chemother. 2009 Mar;63(3):451-7.

N-Terminal clustering of the O-glycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC.  Sartain MJ, Belisle JT.  Glycobiology. 2009 Jan;19(1):38-51.

TLR2 looks at lipoproteins.  Schenk M, Belisle JT, Modlin RL.  Immunity. 2009 Dec 18;31(6):847-9.

Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis.  Sharpe SA, Eschelbach E, Basaraba RJ, Gleeson F, Hall GA, McIntyre A, Williams A, Kraft SL, Clark S, Gooch K, Hatch G, Orme IM, Marsh PD, Dennis MJ.  Tuberculosis (Edinb). 2009 Nov;89(6):405-16.

Post-exposure vaccination against Mycobacterium tuberculosis.  Henao-Tamayo M, Palaniswamy GS, Smith EE, Shanley CA, Wang B, Orme IM, Basaraba RJ, DuTeau NM, Ordway D.  Tuberculosis (Edinb). 2009 Mar;89(2):142-8.

Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs.  Palanisamy GS, DuTeau N, Eisenach KD, Cave DM, Theus SA, Kreiswirth BN, Basaraba RJ, Orme IM.  Tuberculosis (Edinb). 2009 May;89(3):203-9.

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys.  Reed SG, Coler RN, Dalemans W, Tan EV, DeLa Cruz EC, Basaraba RJ, Orme IM, Skeiky YA, Alderson MR, Cowgill KD, Prieels JP, Abalos RM, Dubois MC, Cohen J, Mettens P, Lobet Y.  Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2301-6. Epub 2009 Feb 2. Erratum in: Proc Natl Acad Sci U S A.2009 May 5;106(18):7678. Dalemans, Wilifred [corrected to Dalemans, Wilfried].

Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Eoh H, Narayanasamy P, Brown AC, Parish T, Brennan PJ, Crick DC Chem Biol. 2009 Dec 24;16(12):1230-9.

MenA is a promising drug target for developing novel lead molecules to combat Mycobacterium tuberculosis. Kurosu M, Crick DC. Med Chem. 2009 Mar;5(2):197-207.

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence. Dhiman RK, Mahapatra S, Slayden RA, Boyne ME, Lenaerts A, Hinshaw JC, Angala SK, Chatterjee D, Biswas K, Narayanasamy P, Kurosu M, Crick DC. Mol Microbiol. 2009 Apr;72(1):85-97.

Rapid screening of inhibitors of Mycobacterium tuberculosis growth using tetrazolium salts. Amin AG, Angala SK, Chatterjee D, Crick DC. Methods Mol Biol. 2009;465:187-201.

Implications of high level pseudogene transcription in Mycobacterium leprae.  Williams DL, Slayden RA, Amin A, Martinez AN, Pittman TL, Mira A, Mitra A, Nagaraja V, Morrison NE, Moraes M, Gillis TP.  BMC Genomics. 2009 Aug 25;10:397.

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.  Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE.  Bioorg Med Chem. 2009 May 15;17(10):3588-94.

Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.  Lu H, England K, am Ende C, Truglio JJ, Luckner S, Reddy BG, Marlenee NL, Knudson SE, Knudson DL, Bowen RA, Kisker C, Slayden RA, Tonge PJ.  ACS Chem Biol. 2009 Mar 20;4(3):221-31.

Evaluation of new vaccines for tuberculosis in the guinea pig model.  Williams A, Hall Y, Orme IM.  Tuberculosis (Edinb). 2009 Nov;89(6):389-97.

Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry.  Early MA, Lishnevsky M, Gilchrist JM, Higgins DM, Orme IM, Muller WA, Gonzalez-Juarerro M, Schenkel AR.  Exp Mol Pathol. 2009 Oct;87(2):152-8.

Potential complications to TB vaccine testing in animal models.  Orme IM.  Indian J Exp Biol. 2009 Jun;47(6):440-4.

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning.  Coler RN, Dillon DC, Skeiky YA, Kahn M, Orme IM, Lobet Y, Reed SG, Alderson MR. Vaccine. 2009 Jan 7;27(2):223-33. doi: 10.1016/j.vaccine.2008.10.056.

Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.  Woolhiser LK, Hoff DR, Marietta KS, Orme IM, Lenaerts AJ.  Antimicrob Agents Chemother. 2009 Jan;53(1):306-8.

Suppression of IFNgamma+mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression.  Morris KR, Lutz RD, Bai X, McGibney MT, Cook D, Ordway D, Chan ED.  Tuberculosis (Edinb). 2009 Jul;89(4):294-303.

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.  O’Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.  J Nat Prod. 2009 Mar 27;72(3):360-5.

High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors.  Christophe T, Jackson M, Jeon HK, Fenistein D, Contreras-Dominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Kim EH, Lee SY, Kang S, Seo MJ, Park EJ, Skovierová H, Pham H, Riccardi G, Nam JY, Marsollier L, Kempf M, Joly-Guillou ML, Oh T, Shin WK, No Z, Nehrbass U, Brosch R, Cole ST, Brodin P.  PLoS Pathog. 2009 Oct;5(10):e1000645.

Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.  Svetlíková Z, Skovierová H, Niederweis M, Gaillard JL, McDonnell G, Jackson M.  Antimicrob Agents Chemother. 2009 Sep;53(9):4015-8.

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis.  Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM.  J Biol Chem. 2009 Aug 7;284(32):21613-25. Epub 2009 Jun 11.

Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis.  de la Paz Santangelo M, Klepp L, Nuñez-García J, Blanco FC, Soria M, García-Pelayo MC, Bianco MV, Cataldi AA, Golby P, Jackson M, Gordon SV, Bigi F.  Microbiology. 2009 Jul;155(Pt 7):2245-55.

Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.  Hoff DR, Caraway ML, Brooks EJ, Driver ER, Ryan GJ, Peloquin CA, Orme IM, Basaraba RJ, Lenaerts AJ.  Antimicrob Agents Chemother. 2008 Nov;52(11):4137-40..

Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis.  Ordway D, Henao-Tamayo M, Shanley C, Smith EE, Palanisamy G, Wang B, Basaraba RJ, Orme IM.  Clin Vaccine Immunol. 2008 Aug;15(8):1248-58.

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.  Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Higgins JR, Lee EJ, Orme IM, Gonzalez-Juarrero M.  J Immunol. 2008 Apr 1;180(7):4892-900.

Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model.  Palanisamy GS, Smith EE, Shanley CA, Ordway DJ, Orme IM, Basaraba RJ.  Tuberculosis (Edinb). 2008 Jul;88(4):295-306.

Animal model of Mycobacterium abscessus lung infection.  Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt J, Bai X, Basaraba RJ, Orme IM, Chan ED.  J Leukoc Biol. 2008 Jun;83(6):1502-11..

Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.  Lenaerts AJ, Bitting C, Woolhiser L, Gruppo V, Marietta KS, Johnson CM, Orme IM.  Antimicrob Agents Chemother. 2008 Apr;52(4):1513-5.

Preclinical testing of new drugs for tuberculosis: current challenges.  Lenaerts AJ, Degroote MA, Orme IM.  Trends Microbiol. 2008 Feb;16(2):48-54.

Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig.  Basaraba RJ, Bielefeldt-Ohmann H, Eschelbach EK, Reisenhauer C, Tolnay AE, Taraba LC, Shanley CA, Smith EA, Bedwell CL, Chlipala EA, Orme IM.  Tuberculosis (Edinb). 2008 Jan;88(1):69-79.

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.  Respicio L, Nair PA, Huang Q, Anil B, Tracz S, Truglio JJ, Kisker C, Raleigh DP, Ojima I, Knudson DL, Tonge PJ, Slayden RA.  Tuberculosis (Edinb). 2008 Sep;88(5):420-9.

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.  am Ende CW, Knudson SE, Liu N, Childs J, Sullivan TJ, Boyne M, Xu H, Gegina Y, Knudson DL, Johnson F, Peloquin CA, Slayden RA, Tonge PJ.  Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33.

A new Mycobacterium species causing diffuse lepromatous leprosy.  Han XY, Seo YH, Sizer KC, Schoberle T, May GS, Spencer JS, Li W, Nair RG.  Am J Clin Pathol. 2008 Dec;130(6):856-64.

Deciphering the proteomic profile of Mycobacterium leprae cell envelope.  Marques MA, Neves-Ferreira AG, da Silveira EK, Valente RH, Chapeaurouge A, Perales J, da Silva Bernardes R, Dobos KM, Spencer JS, Brennan PJ, Pessolani MC.  Proteomics. 2008 Jun;8(12):2477-91.

Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis.  Huang H, Berg S, Spencer JS, Vereecke D, D’Haeze W, Holsters M, McNeil MR.  Microbiology. 2008 Mar;154(Pt 3):736-43.

Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection.  Taylor JL, Bielefeldt-Ohmann H, Pozzi A, Izzo AA.  Tuberculosis (Edinb). 2008 Sep;88(5):444-52.

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.  Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL.  J Immunol. 2008 May 1;180(9):5833-42.

Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability.  Shi L, Zhou R, Liu Z, Lowary TL, Seeberger PH, Stocker BL, Crick DC, Khoo KH, Chatterjee D.  J Bacteriol. 2008 Aug;190(15):5248-55.

The critical role of embC in Mycobacterium tuberculosis.  Goude R, Amin AG, Chatterjee D, Parish T.  J Bacteriol. 2008 Jun;190(12):4335-41..

Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare.  Fujiwara N, Nakata N, Naka T, Yano I, Doe M, Chatterjee D, McNeil M, Brennan PJ, Kobayashi K, Makino M, Matsumoto S, Ogura H, Maeda S.  J Bacteriol. 2008 May;190(10):3613-21.

The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactan.  Bhamidi S, Scherman MS, Rithner CD, Prenni JE, Chatterjee D, Khoo KH, McNeil MR. J Biol Chem. 2008 May 9;283(19):12992-3000.

EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis.  Amin AG, Goude R, Shi L, Zhang J, Chatterjee D, Parish T.  Microbiology. 2008 Jan;154(Pt 1):240-8.

Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis.  Gest P, Kaur D, Pham HT, van der Woerd M, Hansen E, Brennan PJ, Jackson M, Guerin ME.  Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1121-4.

Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferase.  Kaur D, Obregón-Henao A, Pham H, Chatterjee D, Brennan PJ, Jackson M.  Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17973-7.

Genotyping North American animal Mycobacterium bovis isolates using multilocus variable number tandem repeat analysis.  Martinez LR, Harris B, Black WC 4th, Meyer RM, Brennan PJ, Vissa VD, Jones RL.  J Vet Diagn Invest. 2008 Nov;20(6):707-15.

Molecular methods for distinguishing between relapse and reinfection in leprosy.  Oskam L, Dockrell HM, Brennan PJ, Gillis T, Vissa V, Richardus JH; IDEAL Consortium.  Trop Med Int Health. 2008 Oct;13(10):1325-6.

Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.  Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, Schlesinger LS.  J Biol Chem. 2008 Nov 14;283(46):31417-28.

LightCycler real-time PCR for rapid detection and quantitation of Mycobacterium leprae in skin specimens.  Rudeeaneksin J, Srisungngam S, Sawanpanyalert P, Sittiwakin T, Likanonsakul S, Pasadorn S, Palittapongarnpim P, Brennan PJ, Phetsuksiri B.  FEMS Immunol Med Microbiol. 2008 Nov;54(2):263-70.

Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?  Monot M, Honoré N, Balière C, Ji B, Sow S, Brennan PJ, Cole ST.  J Clin Microbiol. 2008 Jul;46(7):2291-7.

N-D-aldopentofuranosyl-N’-[p-(isoamyloxy)phenyl]-thiourea derivatives: potential anti-TB therapeutic agents.  Liav A, Angala SK, Brennan PJ, Jackson M.  Bioorg Med Chem Lett. 2008 Apr 15;18(8):2649-51.

Galactosyl transferases in mycobacterial cell wall synthesis.  Belánová M, Dianisková P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusová K.  J Bacteriol. 2008 Feb;190(3):1141-5.

Unique structural features of the peptidoglycan of Mycobacterium leprae.  Mahapatra S, Crick DC, McNeil MR, Brennan PJ.  J Bacteriol. 2008 Jan;190(2):655-61

Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country.  Wanchu A, Dong Y, Sethi S, Myneedu VP, Nadas A, Liu Z, Belisle J, Laal S.  PLoS One. 2008 Apr 30;3(4):e2071.

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.  El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, König T, Schleicher U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, Bogdan C, Wynn TA, Murray PJ.  Nat Immunol. 2008 Dec;9(12):1399-406.

Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase. Noike M, Ambo T, Kikuchi S, Suzuki T, Yamashita S, Takahashi S, Kurokawa H, Mahapatra S, Crick DC, Koyama T. Biochem Biophys Res Commun. 2008 Dec 5;377(1):17-22.

Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.

The structural basis of chain length control in Rv1086. Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH. J Mol Biol. 2008 Aug 1;381(1):129-40. Epub 2008 Jul 1.

Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase. Zhang W, Jones VC, Scherman MS, Mahapatra S, Crick D, Bhamidi S, Xin Y, McNeil MR, Ma Y. Int J Biochem Cell Biol. 2008;40(11):2560-71.

Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL. Grzegorzewicz AE, Ma Y, Jones V, CrickD, Liav A, McNeil MR. Microbiology. 2008 Dec;154(Pt 12):3724-30.

Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy.  Honaker RW, Stewart A, Schittone S, Izzo A, Klein MR, Voskuil MI.  Infect Immun. 2008 Jun;76(6):2587-93.

Mycobacterial infection induces the secretion of high-mobility group box 1 protein.  Grover A, Taylor J, Troudt J, Keyser A, Sommersted K, Schenkel A, Izzo AA.  Cell Microbiol. 2008 Jun;10(6):1390-404.

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.  Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R, Vesosky B, Turner J.  J Immunol. 2008 Oct 15;181(8):5545-50.

Partial redundancy in the synthesis of the D-arabinose incorporated in the cell wall arabinan of Corynebacterineae.  Meniche X, de Sousa-d’Auria C, Van-der-Rest B, Bhamidi S, Huc E, Huang H, De Paepe D, Tropis M, McNeil M, Daffé M, Houssin C.  Microbiology. 2008 Aug;154(Pt 8):2315-26.

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.  Hurdle JG, Lee RB, Budha NR, Carson EI, Qi J, Scherman MS, Cho SH, McNeil MR, Lenaerts AJ, Franzblau SG, Meibohm B, Lee RE.  J Antimicrob Chemother. 2008 Nov;62(5):1037-45.

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.  Vicente E, Villar R, Burguete A, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.  Antimicrob Agents Chemother. 2008 Sep;52(9):3321-6.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.  Villar R, Vicente E, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.  J Antimicrob Chemother. 2008 Sep;62(3):547-54.

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics.  Fonvielle M, Coinçon M, Daher R, Desbenoit N, Kosieradzka K, Barilone N, Gicquel B, Sygusch J, Jackson M, Therisod M.  Chemistry. 2008;14(28):8521-9.

The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface.  Pitarque S, Larrouy-Maumus G, Payré B, Jackson M, Puzo G, Nigou J.  Tuberculosis (Edinb). 2008 Nov;88(6):560-5. Epub 2008 Jun 9.

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.  Chesne-Seck ML, Barilone N, Boudou F, Gonzalo Asensio J, Kolattukudy PE, Martín C, Cole ST, Gicquel B, Gopaul DN, Jackson M.  J Bacteriol. 2008 Feb;190(4):1329-34.

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.  Sambou T, Dinadayala P, Stadthagen G, Barilone N, Bordat Y, Constant P, Levillain F, Neyrolles O, Gicquel B, Lemassu A, Daffé M, Jackson M.  Mol Microbiol. 2008 Nov;70(3):762-74.